Patents by Inventor Zemin Zhang

Zemin Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PREDICTING CELL SPATIAL RELATION BASED ON SINGLE-CELL TRANSCRIPTOME SEQUENCING DATA
    Publication number: 20230046438
    Abstract: A method for predicting the cell spatial relation based on single-cell transcriptome sequencing data includes the steps of obtaining a probability matrix P of a cell-cell interaction strength matrix A based on single-cell transcriptome sequencing data; reconstructing, according to the obtained probability matrix P of the cell-cell interaction strength matrix A, a three-dimensional spatial structure in which cells interact with each other; and for each cell in the reconstructed three-dimensional spatial structure in which cells interact with each other, determining the intercellular distance threshold for each cell to interact with h cells on average to obtain an intercellular interaction network. The method requires only the single-cell transcriptome sequencing data to predict the interaction of the cells in three-dimensional space, which breaks the limitation of the existing technology that needs to obtain the spatial relationship of cells through imaging.
    Type: Application
    Filed: January 14, 2020
    Publication date: February 16, 2023
    Inventors: Zemin ZHANG, Xianwen REN, Guojie ZHONG
  • System and method for processing images using online tensor robust principal component analysis
    Patent number: 10217018
    Abstract: A set of input images are acquired sequentially as image tensors. A low-tubal rank tensor and a sparse tensor are initialized using the image tensor, wherein the low-tubal rank tensor is a tensor product of a low-rank spanning tensor basis and corresponding tensor coefficients, and for each image, updating iteratively the image tensor, the tensor coefficients, and the sparse tensor using the image tensor and the low-rank spanning basis from a previous iteration. The spanning tensor basis is updated using the tensor coefficients, the sparse tensor, and the low rank tubal tensor, wherein the low rank tubal tensor represents a set of output images and the sparse tensor representing a set of sparse images.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: February 26, 2019
    Assignee: Mitsubishi Electric Research Laboratories, Inc.
    Inventors: Dehong Liu, Zemin Zhang, Anthony Vetro
  • System and Method for Processing Images using Online Tensor Robust Principal Component Analysis
    Publication number: 20170076180
    Abstract: A set of input images are acquired sequentially as image tensors. A low-tubal rank tensor and a sparse tensor are initialized using the image tensor, wherein the low-tubal rank tensor is a tensor product of a low-rank spanning tensor basis and corresponding tensor coefficients, and for each image, updating iteratively the image tensor, the tensor coefficients, and the sparse tensor using the image tensor and the low-rank spanning basis from a previous iteration. The spanning tensor basis is updated using the tensor coefficients, the sparse tensor, and the low rank tubal tensor, wherein the low rank tubal tensor represents a set of output images and the sparse tensor representing a set of sparse images.
    Type: Application
    Filed: September 15, 2015
    Publication date: March 16, 2017
    Inventors: Dehong Liu, Zemin Zhang, Anthony Vetro
  • Methods for the treatment of tumors expressing TAT123 or naturally occurring variants thereof
    Patent number: 8728480
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: May 20, 2014
    Assignee: Genetech, Inc.
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 8398982
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. TAT113 polypeptides comprising the amino acid sequence of SEQ ID NO: 2 are disclosed. Antibodies that bind TAT113 polypeptides, including monoclonal, chimeric, humanized, single chain, and other antibodies, and fragments thereof, are disclosed. Methods of identifying antibodies that bind epitopes bound by such antibodies, including the antibodies produced by hybridoma cell lines disclosed in the application, are provided, wherein the ability of one antibody to block the binding of another antibody to a TAT113 polypeptide indicates that one antibody binds to an epitope bound by the other antibody.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: March 19, 2013
    Assignee: Genentech, Inc.
    Inventors: Patrick Dowd, Gretchen Frantz, Paul Polakis, Victoria Smith, Susan D. Spencer, Thomas D. Wu, Zemin Zhang
  • Methods for the treatment of tumors expressing TAT123 or naturally occurring variants thereof
    Publication number: 20130064761
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: November 10, 2011
    Publication date: March 14, 2013
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20130011402
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: April 13, 2009
    Publication date: January 10, 2013
    Inventors: Patrick Dowd, Gretchen Frantz, Paul Polakis, Victoria Smith, Susan D. Spencer, Thomas D. Wu, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 8278042
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: October 2, 2012
    Assignee: Genentech, Inc.
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • Composition and Methods for the Diagnosis and Treatment of Tumor
    Publication number: 20120045390
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: September 5, 2003
    Publication date: February 23, 2012
    Applicant: Genentech, Inc.
    Inventors: Frederic J. DeSauvage, William I. Wood, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 8084200
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: December 27, 2011
    Assignee: Genentech, Inc.
    Inventors: Avi J. Ashkenazi, Gretchen Frantz, Audrey Goddard, Lino Gonzalez, Austin L. Gurney, Paul Polakis, Andrew Polson, William I. Wood, Thomas D. Wu, Zemin Zhang
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20110274690
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: April 13, 2009
    Publication date: November 10, 2011
    Inventors: Patrick Dowd, Gretchen Frantz, Paul Polakis, Victoria Smith, Susan D. Spencer, Thomas D. Wu, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 7951546
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: May 31, 2011
    Assignee: Genetech, Inc.
    Inventors: Gretchen Frantz, Kenneth J. Hillan, Heidi Phillips, Paul Polakis, Susan D. Spencer, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 7939268
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: May 10, 2011
    Assignee: Genentech, Inc.
    Inventors: Gretchen Frantz, Kenneth J. Hillan, Heidi Phillips, Paul Polakis, Susan D. Spencer, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20100311050
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: March 22, 2010
    Publication date: December 9, 2010
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20100303834
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: June 30, 2010
    Publication date: December 2, 2010
    Inventors: BELINDA CAIRNS, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang, Mark Sliwkowski
  • PRO34128 nucleic acids
    Publication number: 20100285016
    Abstract: The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: November 19, 2009
    Publication date: November 11, 2010
    Inventors: J. Christopher Grimaldi, Somasekar Seshagiri, Jeremy Stinson, William I. Wood, Zemin Zhang
  • Antibody compositions for the diagnosis and treatment of tumor
    Patent number: 7803915
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: September 28, 2010
    Assignee: Genentech, Inc.
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang, Chie Sakanaka, Anan Chuntharapai, Chae Janeka Reed
  • Compositions and methods for the diagnosis and treatment of tumor
    Patent number: 7767403
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: August 3, 2010
    Assignee: Genentech, Inc.
    Inventors: Gretchen Frantz, Paul Polakis, Susan D. Spencer, Thomas D. Wu, Zemin Zhang
  • Anti-TAT188 antibodies
    Patent number: 7749504
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: July 6, 2010
    Assignee: Genentech, Inc.
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth J. Hillan, Hartmut Koeppen, Heidi S. Phillips, Paul Polakis, Susan D. Spencer, Victoria Smith, P. Mickey Williams, Thomas D. Wu, Zemin Zhang
  • Laser range finder
    Patent number: D881045
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: April 14, 2020
    Inventors: Zemin Zhang, Mingkai Li