Patents by Inventor ZeNan Li CHANG

ZeNan Li CHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSFORMING GROWTH FACTOR-BETA-RESPONSIVE POLYPEPTIDES AND THEIR METHODS FOR USE
    Publication number: 20210277099
    Abstract: Aspects of the disclosure relate to polypeptides comprising a signal peptide, an antigen-binding domain that specifically binds TGF-?, a peptide spacer, a transmembrane domain, and an endodomain. When expressed in a cell, the polypeptides are capable of not only neutralizing the TGF-? but also specifically triggering T-cell activation in the presence of TGF-?. T-cell activation spurs the immune cell to produce immunostimulatory cytokines and proliferate, thus turning TGF-? from an immunosuppressive signal to an activating stimulus.
    Type: Application
    Filed: May 18, 2021
    Publication date: September 9, 2021
    Inventors: Yvonne Yu-Hsuan CHEN, Zenan Li CHANG
  • Transforming growth factor-beta-responsive polypeptides and their methods for use
    Patent number: 11014980
    Abstract: Aspects of the disclosure relate to polypeptides comprising a signal peptide, an antigen-binding domain that specifically binds TGF-?, a peptide spacer, a transmembrane domain, and an endodomain. When expressed in a cell, the polypeptides are capable of not only neutralizing the TGF-? but also specifically triggering T-cell activation in the presence of TGF-?. T-cell activation spurs the immune cell to produce immunostimulatory cytokines and proliferate, thus turning TGF-? from an immunosuppressive signal to an activating stimulus.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: May 25, 2021
    Assignee: The Regents of the University of California
    Inventors: Yvonne Yu-Hsuan Chen, ZeNan Li Chang
  • TRANSFORMING GROWTH FACTOR-BETA-RESPONSIVE POLYPEPTIDES AND THEIR METHODS FOR USE
    Publication number: 20180312580
    Abstract: Aspects of the disclosure relate to polypeptides comprising a signal peptide, an antigen-binding domain that specifically binds TGF-?, a peptide spacer, a transmembrane domain, and an endodomain. When expressed in a cell, the polypeptides are capable of not only neutralizing the TGF-? but also specifically triggering T-cell activation in the presence of TGF-?. T-cell activation spurs the immune cell to produce immunostimulatory cytokines and proliferate, thus turning TGF-? from an immunosuppressive signal to an activating stimulus.
    Type: Application
    Filed: October 28, 2016
    Publication date: November 1, 2018
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yvonne Yu-Hsuan CHEN, ZeNan Li CHANG