Patents by Inventor Zengji Li

Zengji Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cassette encoding a FPV/brachyury fusion protein
    Patent number: 11753652
    Abstract: The present invention relates to one or more promoters and/or expression cassettes that can be used for enhancing expression of a heterologous gene, such as Brachury. In particular, the one or more promoters and/or expression cassettes enhance expression of heterologous genes as part of a viral vector, such as a poxvirus.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: September 12, 2023
    Assignee: Bavarian Nordic A/S
    Inventors: Zengji Li, Alain Delcayre, Ryan Rountree
  • PROMOTERS FOR ENHANCING EXPRESSION IN POXVIRUSES
    Publication number: 20180216134
    Abstract: The present invention relates to one or more promoters and/or expression cassettes that can be used for enhancing expression of a heterologous gene, such as Brachury. In particular, the one or more promoters and/or expression cassettes enhance expression of heterologous genes as part of a viral vector, such as a poxvirus.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 2, 2018
    Applicant: Bavarian Nordic A/S
    Inventors: Zengji Li, Alain Delcayre, Ryan Rountree
  • Stable suspension formulations of erythropoietin receptor agonists
    Patent number: 7772182
    Abstract: A suspension formulation for therapeutic use includes a non-aqueous, single-phase vehicle exhibiting viscous fluid characteristics and a particle formulation comprising an erythropoietin receptor agonist dispersed in the vehicle.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: August 10, 2010
    Assignee: Alza Corporation
    Inventors: Kui Liu, Michael A. Desjardin, Beth L. Hill, Zengji Li
  • Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
    Publication number: 20080112994
    Abstract: A suspension formulation for therapeutic use includes a non-aqueous, hydrophobic vehicle exhibiting viscous fluid characteristics, a dry particle formulation comprising a biomolecule dispersed in the vehicle, and a surfactant incorporated in at least one of the vehicle and dry particle formulation. A dry particle formulation includes an interferon, a buffer, a surfactant, and one or more stabilizers selected from the group consisting of a carbohydrate, an antioxidant, and an amino acid.
    Type: Application
    Filed: January 11, 2008
    Publication date: May 15, 2008
    Inventors: Gunjan Junnarkar, Michael DesJardin, Kui Liu, Zengji Li
  • Method for making liposomes conjugated with temperature-sensitive ligands
    Publication number: 20070264322
    Abstract: The present invention relates to a method of making a liposome composition. In particular, the invention relates to a method of making liposomes targeted to a specific cell receptor for delivery of a liposome-entrapped drug to the cell. In one embodiment, the process involves the incorporation of lipid-linkers to the surface of pre-formed liposomes, preferably at a higher temperature, followed by the conjugation of one or more temperature-sensitive ligands to the linkers associated with the liposome surface at a lower temperature to avoid deactivation of the temperature sensitive ligands. The present invention also is directed to a product prepared according to the foregoing process, and its use to treat subjects. The present invention is also directed to a kit containing lipid-linker, ligand and pre-formed liposome.
    Type: Application
    Filed: May 9, 2007
    Publication date: November 15, 2007
    Inventors: Ken Huang, Zengji Li, Jinkang Wang, Guoyang Zhang, John Grigsby
  • Stable suspension formulations of erythropoietin receptor agonists
    Publication number: 20060030526
    Abstract: A suspension formulation for therapeutic use includes a non-aqueous, single-phase vehicle exhibiting viscous fluid characteristics and a particle formulation comprising an erythropoietin receptor agonist dispersed in the vehicle.
    Type: Application
    Filed: August 1, 2005
    Publication date: February 9, 2006
    Inventors: Kui Liu, Michael Desjardin, Beth Hill, Zengji Li
  • Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
    Publication number: 20050266087
    Abstract: A suspension formulation for therapeutic use includes a non-aqueous, hydrophobic vehicle exhibiting viscous fluid characteristics, a dry particle formulation comprising a biomolecule dispersed in the vehicle, and a surfactant incorporated in at least one of the vehicle and dry particle formulation. A dry particle formulation includes an interferon, a buffer, a surfactant, and one or more stabilizers selected from the group consisting of a carbohydrate, an antioxidant, and an amino acid.
    Type: Application
    Filed: May 19, 2005
    Publication date: December 1, 2005
    Inventors: Gunjan Junnarkar, Michael DesJardin, Kui Liu, Zengji Li