Abstract: An objective of the present invention is to provide methods of producing a cyclic organic compound using a continuous stirred tank reactor(s) (CSTR), the methods being capable of achieving excellent impurity-suppressing effects (quality improvement), reduction in reaction-tank size, continuous production, and such. The present inventors conducted studies on cyclization reactions using a CSTR(s), which had not been conventionally used for cyclization reactions for cyclic compounds. As a result, the inventors have found that the present methods can achieve excellent impurity-suppressing effects (quality improvement), reduction in reaction-tank size, continuous production, and such, as compared with conventional cyclization methods.

Abstract: The present inventors found that, in the synthesis of a peptide compound involving condensation of a C-terminal-activated substance of an acid component with an amine component, the C-terminal-activated substance can be removed by mixing a solution containing a residual C-terminal-activated substance after a condensation reaction with a tertiary amine and water or an aqueous solution.

Abstract: The present invention provides methods for producing peptide compounds. The inventors have found that a cyclic peptide compound can be produced efficiently by linking the N-terminal amino acid residue and the C-terminal amino acid residue of a peptide compound in a solvent containing one or more selected from the group consisting of water-immiscible solvents, water-soluble alkyl nitriles, and water-soluble ethers.

Abstract: An objective of the present invention is to provide methods of producing a cyclic organic compound using a continuous stirred tank reactor(s) (CSTR), the methods being capable of achieving excellent impurity-suppressing effects (quality improvement), reduction in reaction-tank size, continuous production, and such. The present inventors conducted studies on cyclization reactions using a CSTR(s), which had not been conventionally used for cyclization reactions for cyclic compounds. As a result, the inventors have found that the present methods can achieve excellent impurity-suppressing effects (quality improvement), reduction in reaction-tank size, continuous production, and such, as compared with conventional cyclization methods.

Abstract: A tetrazolinone compound of formula (1): wherein R1 and R2 each independently represents a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group, etc.; R4, R5, and R6 each independently represents a hydrogen atom, etc.; A represents a C6-C16 aryl group optionally having one or more atoms or groups selected from Group P, etc.; Q represents the following group Q1, etc.; and X represents an oxygen atom or a sulfur atom, has excellent control activity against pests.

Abstract: A tetrazolinone compound represented by formula (1): wherein Q represents a divalent 5-membered aromatic heterocyclic group optionally having one or more atoms or groups selected from Group P2; A represents a 5- to 10-membered monocyclic or fused ring heterocyclic group optionally having one or more atoms or groups selected from Group P1; R1 and R2 each represents a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group optionally having one or more halogen atoms, etc.; R4, R5, and R6 each represents a hydrogen atom, etc.; and X represents an oxygen atom or a sulfur atom, has excellent control activity against pests.

Abstract: A tetrazolinone compound represented by formula (1): wherein Q represents a divalent 5-membred aromatic heterocyclic group optionally having one or more atoms or groups selected from Group P2; A represents a 5- to 10-membered monocyclic or fused ring heterocyclic group optionally having one or more atoms or groups selected from Group P1; R1 and R2 each represents a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group optionally having one or more halogen atoms, etc.; R4, R5, and R6 each represents a hydrogen atom, etc.; and X represents an oxygen atom or a sulfur atom, has excellent control activity against pests.

Abstract: A tetrazolinone compound of formula (1): wherein R1 and R2 each independently represents a hydrogen atom, etc.; R3 represents a C1-C6 alkyl group, etc.; R4, R5, and R6 each independently represents a hydrogen atom, etc.; A represents a C6-C16 aryl group optionally having one or more atoms or groups selected from Group P, etc.; Q represents the following group Q1, etc.; and X represents an oxygen atom or a sulfur atom, has excellent control activity against pests.