Patents by Inventor Zeren Gao

Zeren Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

IL-17C ANTAGONISTS AND METHODS OF USING THE SAME

Publication number: 20070129302

Abstract: The present invention relates IL-17RE antagonists, such as soluble receptors and anti-IL-17RE antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. IL-17RE is a receptor for IL-17C. The present invention includes soluble IL-17RE, anti-IL-17RE antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.

Type: Application

Filed: October 18, 2006

Publication date: June 7, 2007

Inventors: Zeren Gao, Rolf Kuestner, Mark Appleby, Katherine Lewis, Patricia McKernan, Shannon Okada, David Taft, Joseph Kuijper, Stephen Jaspers, Steven Levin
CYTOKINE RECEPTOR ZCYTOR17

Publication number: 20070105777

Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytorl7, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Type: Application

Filed: January 8, 2007

Publication date: May 10, 2007

Inventors: Cindy Sprecher, Scott Presnell, Zeren Gao, Theodore Whitmore, Joseph Kuijper, Mark Maurer
GROWTH FACTOR HOMOLOG ZVEGF3

Publication number: 20070060507

Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

Type: Application

Filed: October 24, 2006

Publication date: March 15, 2007

Inventors: Zeren Gao, Charles Hart, Christopher Piddington, Paul Sheppard, Kimberly Shoemaker
Methods of using pHHLA2 to co-stimulate T-cells

Publication number: 20070053903

Abstract: The invention provides pHHLA2 co-receptor polypeptides and functional fragments, antibodies to same, isolated polynucleotides encoding same, vectors containing the polynucleotides, cells containing the vectors. Methods of making and using these co-stimulatory pHHLA2 co-receptors molecules are also disclosed.

Type: Application

Filed: May 12, 2006

Publication date: March 8, 2007

Inventors: Zeren Gao, Brian Fox, Steven Levin, Frederick Ramsdell, Edward Howard, Janine Bilsborough
Compositions and methods for modulating immune responses

Publication number: 20070054360

Abstract: The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.

Type: Application

Filed: May 12, 2006

Publication date: March 8, 2007

Inventors: Zeren Gao, Steven Levin, Janine Bilsborough, James West, Cameron Brandt, Frederick Ramsdell, Edward Howard, Erick Chadwick
SOLUBLE ZCYTOR14, ANTI-ZCYTOR14 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION

Publication number: 20070048257

Abstract: The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17F, IL-17A, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. ZcytoR14 is a common receptor for IL-17A and IL-17F. The present invention includes soluble ZcytoR14, anti-ZcytoR14 antibodies and binding partners, as well as methods for antagonizing IL-17F, IL-17A or both IL-17A and IL-17F using such soluble receptors, antibodies and binding partners.

Type: Application

Filed: October 4, 2006

Publication date: March 1, 2007

Inventors: Scott Presnell, Steven Burkhead, Steven Levin, Rolf Kuestner, Zeren Gao, Stephen Jaspers, Janine Bilsborough
NUCLEIC ACID ENCODING CYTOKINE RECEPTOR ZCYTOR17

Publication number: 20070049528

Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Type: Application

Filed: October 20, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Scott Presnell, Zeren Gao, Theodore Whitmore, Joseph Kuijper, Mark Maurer
NUCLEIC ACID ENCODING CYTOKINE RECEPTOR ZCYTOR17

Publication number: 20070048303

Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Type: Application

Filed: October 24, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Scott Presnell, Zeren Gao, Theodore Whitmore, Joseph Kuijper, Mark Maurer
CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS

Publication number: 20070048223

Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

Type: Application

Filed: October 27, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Zeren Gao, Joseph Kuijper, Maria Dasovich, Francis Grant, Scott Presnell, Theodore Whitmore, Angela Hammond, Julia Novak, Jane Gross, Stacey Dillon
SOLUBLE ZCYTOR21, ANTI-ZCYTOR21 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION

Publication number: 20070049525

Abstract: The present invention relates ZcytoR21 antagonists, such as soluble receptors and anti-ZcytoR21 antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. ZcytoR21 is a receptor for IL-17C. The present invention includes soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.

Type: Application

Filed: October 4, 2006

Publication date: March 1, 2007

Inventors: Zeren Gao, Rolf Kuestner, Mark Appleby, Katherine Lewis, Patricia McKernan, Shannon Okada, David Taft, Joseph Kuijper, Stephen Jaspers, Steven Levin
CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS

Publication number: 20070049530

Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

Type: Application

Filed: October 25, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Zeren Gao, Joseph Kuijper, Maria Dasovich, Francis Grant, Scott Presnell, Theodore Whitmore, Angela Hammond, Julia Novak, Jane Gross, Stacey Dillon
CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS

Publication number: 20070048831

Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

Type: Application

Filed: October 25, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Zeren Gao, Joseph Kuijper, Maria Dasovich, Francis Grant, Scott Presnell, Theodore Whitmore, Angela Hammond, Julia Novak, Jane Gross, Stacey Dillon
NUCLEIC ACID ENCODING CYTOKINE RECEPTOR ZCYTOR17

Publication number: 20070048309

Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Type: Application

Filed: October 20, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Scott Presnell, Zeren Gao, Theodore Whitmore, Joseph Kuijper, Mark Maurer
CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS

Publication number: 20070048832

Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

Type: Application

Filed: October 25, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Zeren Gao, Joseph Kuijper, Maria Dasovich, Francis Grant, Scott Presnell, Theodore Whitmore, Angela Hammond, Julia Novak, Jane Gross, Stacey Dollon
CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS

Publication number: 20070048835

Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

Type: Application

Filed: October 25, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Zeren Gao, Joseph Kuijper, Maria Dasovich, Francis Grant, Scott Presnell, Theodore Whitmore, Angela Hammond, Julia Novak, Jane Gross, Stacey Dillon
CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS

Publication number: 20070048222

Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

Type: Application

Filed: October 27, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Zeren Gao, Joseph Kuijper, Maria Dasovich, Francis Grant, Scott Presnell, Theodore Whitmore, Angela Hammond, Julia Novak, Jane Gross, Stacey Dillon
NUCLEIC ACID ENCODING CYTOKINE RECEPTOR ZCYTOR17

Publication number: 20070048308

Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Type: Application

Filed: October 20, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Scott Presnell, Zeren Gao, Theodore Whitmore, Joseph Kuijper, Mark Maurer
CYTOKINE RECEPTOR ZCYTOR17 MULTIMERS

Publication number: 20070048834

Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

Type: Application

Filed: October 25, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Zeren Gao, Joseph Kuijper, Maria Dasovich, Francis Grant, Scott Presnell, Theodore Whitmore, Angela Hammond, Julia Novak, Jane Gross, Stacey Dillon
NUCLEIC ACID ENCODING CYTOKINE RECEPTOR ZCYTOR17

Publication number: 20070048307

Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zyctor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zyctor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Type: Application

Filed: October 20, 2006

Publication date: March 1, 2007

Inventors: Cindy Sprecher, Scott Presnell, Zeren Gao, Theodore Whitmore, Joseph Kuijper, Mark Maurer
SOLUBLE ZCYTOR14, ANTI-ZCYTOR14 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION

Publication number: 20070048826

Abstract: The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-17F, IL-17A, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. ZcytoR14 is a common receptor for IL-17A and IL-17F. The present invention includes soluble ZcytoR14, anti-ZcytoR14 antibodies and binding partners, as well as methods for antagonizing IL-17F, IL-17A or both IL-17A and IL-17F using such soluble receptors, antibodies and binding partners.

Type: Application

Filed: October 4, 2006

Publication date: March 1, 2007

Inventors: Scott Presnell, Steven Burkhead, Steven Levin, Rolf Kuestner, Zeren Gao, Stephen Jaspers, Janine Bilsborough

prev 1 2 3 4 5 6 7 8 9 next