Patents by Inventor Zeren Wang

Zeren Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITIONS
    Publication number: 20230414613
    Abstract: Provided are pharmaceutical compositions which include a mixture of a lipophilic active pharmaceutical ingredient such as nilotinib, a hydrophilic polymer, one or more surfactants, and optionally an adsorbent. Also described are methods for preparing and using such pharmaceutical compositions. In one aspect, disclosed herein is an amorphous solid dispersion comprising the active pharmaceutical ingredient.
    Type: Application
    Filed: March 28, 2023
    Publication date: December 28, 2023
    Inventors: Zeren WANG, Shun CHEN, Jiqian PENG, Longwei Sun, Yanxin Zhao
  • PHARMACEUTICAL COMPOSITIONS OF PROTAC COMPOUNDS AND USES THEREOF
    Publication number: 20230338371
    Abstract: Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional degraders that specifically eliminate targeted proteins by hijacking the ubiquitin-proteasome system (UPS). Provided are pharmaceutical compositions which include a mixture of a PROTAC, a hydrophilic polymer, a surfactant, and optionally an acid and an adsorbent. Also described are methods for preparing and using such pharmaceutical compositions. In one aspect, disclosed herein is an amorphous solid dispersion comprising PROTAC.
    Type: Application
    Filed: June 28, 2023
    Publication date: October 26, 2023
    Inventors: Zeren WANG, Shun CHEN
  • PHARMACEUTICAL FORMULATION OF PALBOCICLIB AND A PREPARATION METHOD THEREOF
    Publication number: 20230226063
    Abstract: The present invention belongs to the pharmaceutical field, and in particular, it relates to a pharmaceutical formulation of palbociclib and a preparation method thereof. The pharmaceutical formulation comprises palbociclib, an acidic auxiliary material, and optionally a hydrophilic high-molecular material, which has better solubility and in vitro dissolution property as compared with the conventional formulation and can be used for enhancing in vivo absorption and bioavailability of palbociclib.
    Type: Application
    Filed: September 28, 2022
    Publication date: July 20, 2023
    Inventors: Zeren WANG, Jun XU, Long QU
  • PHARMACEUTICAL COMPOSITIONS
    Publication number: 20230128252
    Abstract: Provided are pharmaceutical compositions which include an active pharmaceutical ingredient having a calculated log P in octanol-water equal or greater than about 4.0, at least one solubilizer, and optionally at least one stratum corneum penetration enhancer, wherein the pharmaceutical composition can be formulated for topical administration. In some instances, the active pharmaceutical ingredient is clofazimine.
    Type: Application
    Filed: October 11, 2022
    Publication date: April 27, 2023
    Inventors: Zeren WANG, Jun XU, Peter FARINA, Shun CHEN
  • Pharmaceutical compositions of amorphous solid dispersions and methods of preparation thereof
    Patent number: 11471418
    Abstract: Provided are amorphous solid dispersions comprising an active pharmaceutical ingredient and pharmaceutical compositions comprising the amorphous solid dispersions. Also described herein are methods for preparing and using such compositions. In some embodiments, an amorphous solid dispersion comprises an active pharmaceutical ingredient such as palbociclib or neratinib, one or more acids, and a high-molecular weight material.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: October 18, 2022
    Assignee: Shenzhen Pharmacin Co., Ltd.
    Inventors: Zeren Wang, Shun Chen, Longwei Sun, Yanxin Zhao
  • Pharmaceutical formulation of palbociclib and a preparation method thereof
    Patent number: 11464779
    Abstract: The present invention belongs to the pharmaceutical field, and in particular, it relates to a pharmaceutical formulation of palbociclib and a preparation method thereof. The pharmaceutical formulation comprises palbociclib, an acidic auxiliary material, and optionally a hydrophilic high-molecular material, which has better solubility and in vitro dissolution property as compared with the conventional formulation and can be used for enhancing in vivo absorption and bioavailability of palbociclib.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: October 11, 2022
    Assignee: Shenzhen Pharmacin Co., Ltd.
    Inventors: Zeren Wang, Jun Xu, Long Qu
  • PHARMACEUTICAL COMPOSITIONS
    Publication number: 20220193095
    Abstract: Provided are pharmaceutical compositions which comprise a mixture of a lipophilic active pharmaceutical ingredient, at least one long chain fatty acid or at least one fatty acid glyceride, a surfactant, and optionally an antioxidant. Also described are methods for preparing and using such pharmaceutical compositions. The active pharmaceutical ingredient in such a combination has improved bioavailability compared to the active pharmaceutical ingredient alone.
    Type: Application
    Filed: March 11, 2020
    Publication date: June 23, 2022
    Inventors: Zeren Wang, Shun Chen
  • PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL DOSAGE FORM, PROCESS FOR THEIR PREPARATION, METHODS FOR TREATING AND USES THEREOF
    Publication number: 20220193045
    Abstract: The present invention relates to pharmaceutical compositions comprising a SGLT-2 inhibitor, pharmaceutical dosage forms, their preparation, their use and methods for treating metabolic disorders.
    Type: Application
    Filed: March 4, 2022
    Publication date: June 23, 2022
    Inventors: Wolfram EISENREICH, Nadia S. LADYZHYNSKY, Danping LI, Leon SCHULTZ, Zeren WANG, Sreeraj MACHA, Albert BARTA
  • PHARMACEUTICAL COMPOSITIONS OF AMORPHOUS SOLID DISPERSIONS AND METHODS OF PREPARATION THEREOF
    Publication number: 20220096389
    Abstract: Provided are amorphous solid dispersions comprising an active pharmaceutical ingredient and pharmaceutical compositions comprising the amorphous solid dispersions. Also described herein are methods for preparing and using such compositions. In some embodiments, an amorphous solid dispersion comprises an active pharmaceutical ingredient such as palbociclib or neratinib, one or more acids, and a high-molecular weight material.
    Type: Application
    Filed: November 13, 2020
    Publication date: March 31, 2022
    Inventors: Zeren WANG, Shun CHEN, Longwei SUN, Yanxin ZHAO
  • PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREFOR
    Publication number: 20210401819
    Abstract: The present invention provides an oral pharmaceutical composition and a usage thereof, comprising a pharmaceutically acceptable acidic medicinal auxiliary material whose surface is modified and dabigatran etexilate or pharmaceutically acceptable salts or aquo-complexes thereof. The present invention further provides a surface modification method for a medicinal auxiliary material.
    Type: Application
    Filed: July 7, 2021
    Publication date: December 30, 2021
    Inventors: Zeren Wang, Yulan Zhao, Lijiang Wang, Xiao Zhang, Jun Xu, Shunqin Chen, Meili Sun, Guisheng Jiang
  • Preparation method therefor
    Patent number: 11083721
    Abstract: The present invention provides an oral pharmaceutical composition and a usage thereof, comprising a pharmaceutically acceptable acidic medicinal auxiliary material whose surface is modified and dabigatran etexilate or pharmaceutically acceptable salts or aquo-complexes thereof. The present invention further provides a surface modification method for a medicinal auxiliary material.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: August 10, 2021
    Assignee: Shenzhen Pharmacin Co., Ltd.
    Inventors: Zeren Wang, Yulan Zhao, Lijiang Wang, Xiao Zhang, Jun Xu, Shunqin Chen, Meili Sun, Guisheng Jiang
  • Pharmaceutical formulation of palbociclib and a preparation method thereof
    Patent number: 10894049
    Abstract: The present invention belongs to the pharmaceutical field, and in particular, it relates to a pharmaceutical formulation of palbociclib and a preparation method thereof. The pharmaceutical formulation comprises palbociclib, an acidic auxiliary material, and optionally a hydrophilic high-molecular material, which has better solubility and in vitro dissolution property as compared with the conventional formulation and can be used for enhancing in vivo absorption and bioavailability of palbociclib.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: January 19, 2021
    Assignee: Shenzhen Pharmacin Co., Ltd.
    Inventors: Zeren Wang, Jun Xu, Long Qu
  • PHARMACEUTICAL FORMULATION OF PALBOCICLIB AND A PREPARATION METHOD THEREOF
    Publication number: 20210000835
    Abstract: The present invention belongs to the pharmaceutical field, and in particular, it relates to a pharmaceutical formulation of palbociclib and a preparation method thereof. The pharmaceutical formulation comprises palbociclib, an acidic auxiliary material, and optionally a hydrophilic high-molecular material, which has better solubility and in vitro dissolution property as compared with the conventional formulation and can be used for enhancing in vivo absorption and bioavailability of palbociclib.
    Type: Application
    Filed: September 17, 2020
    Publication date: January 7, 2021
    Inventors: Zeren Wang, Jun Xu, Long Qu
  • Pharmaceutical composition and preparation method therefor
    Patent number: 10864204
    Abstract: The present invention provides an oral pharmaceutical composition and a usage thereof, comprising a pharmaceutically acceptable acidic medicinal auxiliary material whose surface is modified and dabigatran etexilate or pharmaceutically acceptable salts or aquo-complexes thereof. The present invention further provides a surface modification method for a medicinal auxiliary material.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: December 15, 2020
    Assignee: SHENZHEN PHARMACIN CO., LTD.
    Inventors: Zeren Wang, Yulan Zhao, Lijiang Wang, Xiao Zhang, Jun Xu, Shunqin Chen, Meili Sun, Guisheng Jiang
  • Pharmaceutical formulation of palbociclib and a preparation method thereof
    Patent number: 10813937
    Abstract: The present invention belongs to the pharmaceutical field, and in particular, it relates to a pharmaceutical formulation of palbociclib and a preparation method thereof. The pharmaceutical formulation comprises palbociclib, an acidic auxiliary material, and optionally a hydrophilic high-molecular material, which has better solubility and in vitro dissolution property as compared with the conventional formulation and can be used for enhancing in vivo absorption and bioavailability of palbociclib.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: October 27, 2020
    Assignee: Shenzhen Pharmacin Co., Ltd.
    Inventors: Zeren Wang, Jun Xu, Long Qu
  • Polymorph of triaryldimethylpiperazine dihydrochloride and preparation method and application thereof
    Patent number: 10730851
    Abstract: The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament for preventing or treating a mood disorder or a disease related to a ? opioid receptor.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: August 4, 2020
    Assignee: Yunnan Institute of Materia Medica
    Inventors: Jingkun Wang, Zhaoyun Zhu, He Song, Min Sun, Tao Cui, Zeren Wang, Zhi Yang, Min Su, Hongbin Liu, Bing Shi, Yong Mao, Huilang Liu, Zeqian Li, Chunmei Zhao, Mei Su, Fang Yuan, Tiancai Zhang, Yong Liu, Kuanren Zhang, Yunlin Wei, Yuehai Shen
  • PHARMACEUTICAL COMPOSITIONS
    Publication number: 20200237784
    Abstract: Provided are pharmaceutical compositions which comprise a mixture of a lipophilic active pharmaceutical ingredient, at least one long chain fatty acid or at least one fatty acid glyceride, a surfactant, and optionally an antioxidant. Also described are methods for preparing and using such pharmaceutical compositions. The active pharmaceutical ingredient in such a combination has improved bioavailability compared to the active pharmaceutical ingredient alone.
    Type: Application
    Filed: March 11, 2020
    Publication date: July 30, 2020
    Inventors: Zeren Wang, Shun Chen
  • PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREFOR
    Publication number: 20200129494
    Abstract: The present invention provides an oral pharmaceutical composition and a usage thereof, comprising a pharmaceutically acceptable acidic medicinal auxiliary material whose surface is modified and dabigatran etexilate or pharmaceutically acceptable salts or aquo-complexes thereof. The present invention further provides a surface modification method for a medicinal auxiliary material.
    Type: Application
    Filed: December 26, 2019
    Publication date: April 30, 2020
    Inventors: Zeren Wang, Yulan ZHAO, Lijiang WANG, Xiao ZHANG, Jun XU, Shunqin CHEN, Meili SUN, Guisheng JIANG
  • PHARMACEUTICAL FORMULATION OF PALBOCICLIB AND A PREPARATION METHOD THEREOF
    Publication number: 20190381051
    Abstract: The present invention belongs to the pharmaceutical field, and in particular, it relates to a pharmaceutical formulation of palbociclib and a preparation method thereof. The pharmaceutical formulation comprises palbociclib, an acidic auxiliary material, and optionally a hydrophilic high-molecular material, which has better solubility and in vitro dissolution property as compared with the conventional formulation and can be used for enhancing in vivo absorption and bioavailability of palbociclib.
    Type: Application
    Filed: August 28, 2019
    Publication date: December 19, 2019
    Inventors: Zeren WANG, Jun XU, Long QU
  • PHARMACEUTICAL FORMULATION OF PALBOCICLIB AND A PREPARATION METHOD THEREOF
    Publication number: 20190381050
    Abstract: The present invention belongs to the pharmaceutical field, and in particular, it relates to a pharmaceutical formulation of palbociclib and a preparation method thereof. The pharmaceutical formulation comprises palbociclib, an acidic auxiliary material, and optionally a hydrophilic high-molecular material, which has better solubility and in vitro dissolution property as compared with the conventional formulation and can be used for enhancing in vivo absorption and bioavailability of palbociclib.
    Type: Application
    Filed: August 28, 2019
    Publication date: December 19, 2019
    Inventors: Zeren WANG, Jun XU, Long QU