Patents by Inventor Zev Binder

Zev Binder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATION OF CAR MODIFIERS FOR TUMOR TREATMENT
    Publication number: 20240374641
    Abstract: The present disclosure provides modified immune cells or precursors thereof (e.g. T cells) comprising a first chimeric antigen receptor (CAR) capable of binding human IL13R?2, a second CAR capable of binding EGFR or an isoform thereof, and a dominant negative TGF? type II receptor (DN-TGF?RII). Compositions and methods of treatment are also provided.
    Type: Application
    Filed: March 13, 2024
    Publication date: November 14, 2024
    Inventors: Donald M. O'Rourke, Zev Binder, Jesse L. Rodriguez, Nannan Li
  • Compositions and Methods Comprising a High Affinity Chimeric Antigen Receptor (CAR) with Cross-Reactivity to Clinically-Relevant EGFR Mutated Proteins
    Publication number: 20220184129
    Abstract: The present invention includes compositions and methods that utilize a high affinity chimeric antigen receptor (CAR) with cross-reactivity to clinically-relevant EGFR mutated proteins.
    Type: Application
    Filed: April 11, 2020
    Publication date: June 16, 2022
    Inventors: Donald O'ROURKE, Zev BINDER, Michael MILONE, Radhika THOKALA
  • SYNTHETIC CARS TO TREAT IL13R-alpha-2 POSITIVE HUMAN AND CANINE TUMORS
    Publication number: 20210128617
    Abstract: The present disclosure provides modified immune cells or precursors thereof (e.g. T cells) comprising chimeric antigen receptors (CARs) capable of binding human IL13R?2. Also provided are bispecific CARs, parallel CARs, tandem CARs, BiTEs, BiTE/CARs, and BiTE/BiTEs. Compositions and methods of treatment are also provided.
    Type: Application
    Filed: August 27, 2020
    Publication date: May 6, 2021
    Inventors: Donald M. O'Rourke, Yibo Yin, Laura Johnson, Zev Binder, Radhika Thokala