Abstract: The present disclosure provides a method of treating hypercholesterolemia and other conditions related to PCSK9 activity, e.g. atherosclerosis, atherosclerotic cardiovascular disease, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions, by orally administering to the subject an amount of a compound of formula (I) wherein A? is selected from a pharmaceutically acceptable anion, and wherein the amount administered is from about 5 mg to about 300 mg of the compound of formula (I). The present invention is also directed to pharmaceutical compositions comprising a compound of formula (I), including particular salts of a compound of formula (I), and a permeation enhancer.

Abstract: The disclosed embodiments include a method, apparatus, and computer program product for monitoring underbalanced drilling operations. For example, one disclosed embodiment is a system that includes at least one processor and at least one memory coupled to the at least one processor and storing instructions that when executed by the at least one processor performs operations for generating a three dimensional tunnel view of an operating envelope of a well as the well is being drilled.

Abstract: The disclosed embodiments include a method, apparatus, and computer program product for monitoring underbalanced drilling operations. For example, one disclosed embodiment is a system that includes at least one processor and at least one memory coupled to the at least one processor and storing instructions that when executed by the at least one processor performs operations for generating a three dimensional tunnel view of an operating envelope of a well as the well is being drilled.