Patents by Inventor Zhan-qi Niu

Zhan-qi Niu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inclusion complexes of butylphthalide with cyclodextrin or its derivatives, a process for their preparation and the use thereof
    Patent number: 7678776
    Abstract: The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl-?-cyclodextrin in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: March 16, 2010
    Assignee: Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.
    Inventors: Zhan-qi Niu, Kai Zhao, Wen-juan Liu, Gui-rong Zhou, Chao Liu, Rong-duan Wang, Hong-zhong Yuan, Wen-min Guo, Sui-chao Yan, Min Bai
  • INCLUSION COMPLEXES OF BUTYLPHTHALIDE WITH CYCLODEXTRIN OR ITS DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THE USE THEREOF
    Publication number: 20080318898
    Abstract: The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl-?-cyclodextrin in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others.
    Type: Application
    Filed: August 28, 2008
    Publication date: December 25, 2008
    Applicant: Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.
    Inventors: Zhan-qi Niu, Kai Zhao, Wen-juan Liu, Gui-rong Zhou, Chao Liu, Rong-duan Wang, Hong-zhong Yuan, Wen-min Guo, Sui-chao Yan, Min Bai
  • Clathrates of butylphtualide with cyclodextrin or its derivatives, a process for their preparation and the use thereof
    Publication number: 20060166931
    Abstract: The present invention relates to the inclusion complexes of butylphthalide, which is D,L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl-?-cyclodextrin, in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others.
    Type: Application
    Filed: August 21, 2002
    Publication date: July 27, 2006
    Inventors: Zhan-qi Niu, Kai Zhao, Wen-juan Liu, Gui-rong Zhou, Chao Liu, Rong-duan Wang, Hong-zhong Yuan, Wen-min Guo, Sui-chao Yan, Min Bai