Abstract: The present disclosure is directed to compounds having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.

Abstract: A slide rail assembly includes a first rail with a positioning structure, a second rail displaceable relative to the first rail and providing a concave surface on the back to face the positioning structure, a first stopper pivotally connected to the concave surface corresponding to the first side of the positioning structure, and an operating member movably connected to the second rail and placed on the concave surface so that the operating member is on the side of the first stopper. The slide rail assembly can be installed on the side of the carrier, which can be a server case or drawer, or can be used on servers or furniture.

Abstract: A blockchain-based data processing method and apparatus, a computer device, and a computer-readable storage medium.

Abstract: Disclosed herein are compounds having a structure according to Formula I, and compositions containing those compounds. Methods of preparing the compounds, and methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.

Abstract: The present disclosure describes processes and intermediates useful for preparing a compound of Formula (Xa) or Formula (Xb). The processes and intermediates can be used to prepare the compounds of the disclosure at multigram or kilogram scale.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: A blockchain-based data processing method and apparatus, a computer device, and a computer-readable storage medium.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: Described herein is a process for the total synthesis of macrolactones and macrolactams of formula I including E- and Z-configuration thereof, in particular, nannocystins.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: A gas turbine engine includes a compressor delivering air into a combustion section. The combustion section and the compressor are housed in a housing. An air supply system communicates through the housing to deliver air from a location between an upstream end of the compressor, and an upstream end of the combustor. A diffuser is positioned downstream of the compressor. An opening in the housing supplies air to the inlet end. The diffuser has an outer shroud and an inner shroud with intermediate vanes. The outer shroud ends at a location upstream of a downstream end of the inner shroud at locations circumferentially aligned with the inlet end. The outer shroud only ends at the upstream location at circumferential locations associated with the inlet end, but extends further downstream at other locations.

Abstract: A method and system for implementing verification within data transfer are provided. The method includes obtaining a user card identifier and a data transfer password of a selected user card through a data transfer request interface. A data transfer verification request to a data transfer server is initiated, the data transfer verification request being generated according to the user card identifier, the data transfer password and a data transfer user identifier. A current time valid identifier that is returned by the data transfer server is received when the data transfer verification is passed, the current time valid identifier being issued when the data transfer server determines that the current time does not exceed a valid period of card-binding time of the selected user card. A secondary verification interface is skipped according to the current time valid identifier. A data transfer confirmation interface is entered.

Abstract: Disclosed herein are expression constructs and methods for producing a protein of interest. According to some examples, an expression construct includes a nucleotide sequence encoding a fusion protein. To produce the protein of interest, the expression construct is transformed into a host cell, which is cultured under conditions that allow the expression of the fusion protein. The fusion protein has at least one expression unit; each expression unit has, sequentially, an affinity tag moiety, a spacer moiety, an enzymatic cleavage site, and a protein of interest moiety. The fusion protein is isolated from the host cell, solubilized, and refolded. The refolded fusion protein is cleaved to release the protein of interest.

Abstract: A gas turbine engine includes a mid-turbine frame that includes an inner frame case. At least one spoke is connected to the inner frame case. At least one spoke includes a fluid passage that is in fluid communication with a channel on a radially inner end of the fluid passage. The channel is directed in a radially inward and circumferential direction. A cavity is located radially inward from the mid-turbine frame and is in fluid communication with the channel.

Abstract: A bleed air supply system for a gas turbine engine comprising a duct having an inlet end and extending to an outlet end. The inlet end of the duct is provided with a central insert. In another feature, there may be a plurality of ducts, and inlet ends of the plurality of ducts being spaced by at least 90°. In another feature, a compressor may have a diffuser with a shroud ending upstream of the downstream end of an inner shroud, having an outer shroud ending at a location upstream of a downstream end of an inner shroud at locations circumferentially aligned with an inlet end of the duct.

Abstract: A turbine engine includes a turbine section with a low pressure turbine and a turbine case disposed about an axis. A frame assembly defines an outer cavity and an inner cavity with the outer cavity including at least one opening configured and adapted to communicate cooling air to the turbine case. A transfer tube is disposed within the outer cavity and is configured and adapted to receive cooling air. The transfer tube includes a bend configured to impart circumferential velocity to the cooling air within the outer cavity.