Abstract: In one aspect, embodiments disclosed herein are directed to engineered CRISPRCas effector proteins that comprise at least one modification compared to an unmodified CRISPR-Cas effector protein that enhances binding of the of the CRISPR complex to the binding site and/or alters editing preference as compared to wild type. In certain example embodiments, the CRISPR-Cas effector protein is a Type II effector protein. In certain other example embodiments, the Type V effector protein is Cas9 or an orthologs or engineered variant thereof. Example Cas9 proteins suitable for use in the embodiments disclosed herein are discussed in further detail below.

Abstract: The present invention provides a method for treating a copper-containing waste etching solution, which includes: preparing basic copper chloride nanometer seed crystals and synthesizing basic copper chloride mono-crystals; making an acidic waste etching solution subjected to agglomeration reaction with an ammonium-containing solution and slurry containing the basic copper chloride mono-crystals to obtain basic copper chloride crystal particles and copper-removed waste solution; making an alkaline waste etching solution react with sulfuric acid to obtain a copper sulfate mixed solution; and then evaporating, concentrating, cooling and crystallizing the copper sulfate mixed solution obtained by the reaction of the alkaline waste etching solution and the sulfuric acid in sequence to obtain copper sulfate pentahydrate solids.

Abstract: The present invention provides a composition comprising an antiviral agent and a C—X—C chemokine receptor type 4 (CXCR4) antagonist, and methods for using the same. Compositions and methods of the invention can be used to treat viral infection, immune disorders (e.g., rheumatoid arthritis), pulmonary fibrosis, or any other clinical condition associated with abnormal expression (e.g., overexpression and/or upregulation) of CXCR4. Compounds of the invention can also be used in stem cell therapeutics.

Abstract: Embodiments of the present disclosure relate to a method, a device and a computer program product for recovering data. The method comprises in response to receiving a request to recover data from a backup node to a source node, determining a plurality of candidate backup nodes having copies of the data; determining respective performance indicators of the plurality of candidate backup nodes; and determining, from the plurality of candidate backup nodes, the backup node for recovering the data to the source node based on the respective performance indicators of the plurality of candidate backup nodes.

Abstract: A method may be performed using a server. The method may include receiving an identity authentication request associated with a user, generating authentication information based on the identity authentication request, and generating candidate information based on the authentication information such that the authentication information is a subset of the candidate information. The candidate information may be displayed at a randomly selected location. The user may provide input through a graphic input interface to select the authentication information from among the candidate information.

Abstract: When a security authentication request sent by a terminal is received, an identity authentication solution includes acquiring network environment information and user behavior data according to the security authentication request, then determining, according to the network environment information and the user behavior data, whether a current operation is a machine attack, and acquiring a CAPTCHA of a predetermined type according to a predetermined policy and delivering the CAPTCHA to the terminal if the current operation is a machine attack, to perform identity authentication, or determining that security authentication succeeds if the current operation is not a machine attack.

Abstract: For sewage sludge reduction, an apparatus includes a front-end auxiliary filter plate, a back-end auxiliary filter plate, and a plurality of filter plate modules disposed between the front-end auxiliary filter plate and the back-end auxiliary filter plate. Each filter plate module includes a middle main filter plate, a middle auxiliary filter plate, and a plurality of electromagnetic modules comprising an electromagnetic coil wound around an electromagnetic core. The middle main filter plate and the middle auxiliary filter plate are disposed at opposite sides of the electromagnetic modules. An electric current is applied to the electromagnetic coil, attracting the middle auxiliary filter plates and the main filter plates and applying pressure to the sewage sludge.

Abstract: For sewage sludge reduction, an apparatus includes a front-end auxiliary filter plate, a back-end auxiliary filter plate, and a plurality of filter plate modules disposed between the front-end auxiliary filter plate and the back-end auxiliary filter plate. Each filter plate module includes a middle main filter plate, a middle auxiliary filter plate, and a plurality of electromagnetic modules comprising an electromagnetic coil wound around an electromagnetic core. The middle main filter plate and the middle auxiliary filter plate are disposed at opposite sides of the electromagnetic modules. An electric current is applied to the electromagnetic coil, attracting the middle auxiliary filter plates and the main filter plates and applying pressure to the sewage sludge.

Abstract: When a security authentication request sent by a terminal is received, an identity authentication solution includes acquiring network environment information and user behavior data according to the security authentication request, then determining, according to the network environment information and the user behavior data, whether a current operation is a machine attack, and acquiring a CAPTCHA of a predetermined type according to a predetermined policy and delivering the CAPTCHA to the terminal if the current operation is a machine attack, to perform identity authentication, or determining that security authentication succeeds if the current operation is not a machine attack.

Abstract: A system includes a GPS receiver that generates a signal that is representative of a posted speed limit at a location where a vehicle is located and a device that generates a signal that is representative of an actual speed of the vehicle. A controller is responsive to the GPS receiver signal and the actual speed sensor signal for either (1) generating an alarm or (2) limiting or otherwise controlling the speed of the vehicle when the actual speed of the vehicle is greater than the posted speed limit.

Abstract: A method and system for changing a digital signal processing (DSP) mode of an audio system in a motor vehicle having a roof movable between open and closed positions. The open/closed position of the roof is determined and the audio system is operated in a first DSP mode when the roof is in the closed position and operated in a second DSP mode when the roof in the open position. The first and second DSP modes have different processing characteristics adapted for the acoustics of the passenger cabin when the roof is closed or open. The open/closed roof position may be determined by a roof position sensor or by the actuation of a roof position switch operated by a vehicle occupant.

Abstract: A system includes a GPS receiver that generates a signal that is representative of a posted speed limit at a location where a vehicle is located and a device that generates a signal that is representative of an actual speed of the vehicle. A controller is responsive to the GPS receiver signal and the actual speed sensor signal for either (1) generating an alarm or (2) limiting or otherwise controlling the speed of the vehicle when the actual speed of the vehicle is greater than the posted speed limit.

Abstract: A windshield wiper system for use on a hybrid electric vehicle is capable of adjusting the delay between consecutive cycles based on engine state and vehicle speed. The system includes a windshield wiper and a motor coupled to the windshield wiper. A sensor generates an engine speed signal and another sensor generates a vehicle speed signal. A processor in communication with the sensors and wiper motor provides a drive signal to the wiper motor which is based on the engine and vehicle speed.

Abstract: A windshield wiper system for use on a hybrid electric vehicle is capable of adjusting the delay between consecutive cycles based on engine state and vehicle speed. The system includes a windshield wiper and a motor coupled to the windshield wiper. A sensor generates an engine speed signal and another sensor generates a vehicle speed signal. A processor in communication with the sensors and wiper motor provides a drive signal to the wiper motor which is based on the engine and vehicle speed.

Abstract: The present invention screens a number of thermal stable proteins at a time. And the proteins are rapidly identified by using a mass spectrometry. The proteins obtained after screening can be gene cloned to determine its soluble temperature. By using the present invention, time, cost and human resource can be saved.