Abstract: In some embodiments, the subject matter of this disclosure relates to systems and methods for designing and conducting clinical trials and biomarker validation studies. An example method includes: obtaining access to a trained computer-implemented model; providing, to the trained computer-implemented model, a plurality of sets of values for a plurality of features, each set of values corresponding to a candidate individual from a set of candidate individuals; receiving, from the trained computer-implemented model, a prediction of a disease state for each set of values; identifying, from the predictions of the disease state, a group of participants from the set of candidate individuals; and facilitating at least one of a clinical trial or a biomarker validation study involving the group of participants.

Abstract: A lithium-ion battery negative electrode with improved temperature rise performance, and a lithium-ion battery. The negative electrode comprises a negative electrode current collector and a negative electrode material applied to the negative electrode current collector, the negative electrode material containing a conductive agent, the conductive agent comprising SP and CNT, wherein the mass ratio of SP to CNT is 30-1500, preferably 35-100, more preferably 40-70, and further preferably 50-55. The lithium-ion battery comprises a positive electrode, a negative electrode, an electrolyte and a casing, wherein the negative electrode is the negative electrode for a lithium-ion battery as described above. In the present invention, the temperature rise performance of a lithium-ion battery is improved by using a variety of conductive agents and adjusting types and proportions within the conductive agent, without increasing the proportion of conductive agent in the electrode material formula.

Abstract: The present invention discloses a preparation method of a biomedical titanium implant with a function of eliminating a surface biomembrane. The method includes the following steps: firstly synthesizing mesoporous polydopamine (MPDA) nanoparticles by a “one-pot method”, constituting a surface-aminated titanium material through diacid corrosion and modification of a 3-aminopropyltriethoxysilane (APTES) coupling agent, and integrating the MPDA nanoparticles into the surface of the titanium material through Michael addition reaction; secondly, taking MPDA anchored on the surface of the titanium material as a photothermal material and a photosensitizer carrier, where MPDA contains abundant aromatic rings capable of facilitating abundant loading of a photosensitizer (indocyanine green, ICG) through ?-? stacking interaction; and finally further modifying biocompatible RGD polypeptides on the surface of MPDA by Michael addition reaction, where a modified titanium material is referred to as Ti-M/I/RGD.

Abstract: An environmental data monitoring and feedback controlling system and a method thereof are disclosed, a first wireless transceiver module is electrically connected to environmental sensors to form a sensor module, a server is electrically connected to a second wireless transceiver module to form a network gateway, and the server polls the sensor module to receive and store the environmental data through the network gateway, and permits a display panel device to load and display the stored environmental data in a chart. When the environmental data exceeds a preset threshold, a warning device is driven to write the received environmental data into a register of a programmable logic controller of an air conditioning device, so that the control logic automatically controls the air conditioning device to activate or stop based on the environmental data stored in the register, thereby improving the correction immediacy for environmental abnormality.

Abstract: The present invention discloses a preparation method of a biomedical titanium implant with a function of eliminating a surface biomembrane. The method includes the following steps: firstly synthesizing mesoporous polydopamine (MPDA) nanoparticles by a “one-pot method”, constituting a surface-aminated titanium material through diacid corrosion and modification of a 3-aminopropyltriethoxysilane (APTES) coupling agent, and integrating the MPDA nanoparticles into the surface of the titanium material through Michael addition reaction; secondly, taking MPDA anchored on the surface of the titanium material as a photothermal material and a photosensitizer carrier, where MPDA contains abundant aromatic rings capable of facilitating abundant loading of a photosensitizer (indocyanine green, ICG) through ?-? stacking interaction; and finally further modifying biocompatible RGD polypeptides on the surface of MPDA by Michael addition reaction, where a modified titanium material is referred to as Ti-M/I/RGD.

Abstract: A filter device may include a filter housing cover defining a chamber and an annular filter element arranged within the receiving chamber. The filter device may further include a housing and at least one intermediate piece arranged between the filter housing cover and the housing when the cover is secured to the housing. An inlet duct may be in communication with an untreated side of the filter element and an outlet duct may be in communication with a clean side of the filter element. A drainage duct may be arranged in the housing for draining the chamber during removal of the cover. A closure device may be arrange in the intermediate piece and have a closure element configured to close the drainage duct.

Abstract: A filter device may include a filter housing cover defining a chamber and an annular filter element arranged within the receiving chamber. The filter device may further include a housing and at least one intermediate piece arranged between the filter housing cover and the housing when the cover is secured to the housing. An inlet duct may be in communication with an untreated side of the filter element and an outlet duct may be in communication with a clean side of the filter element. A drainage duct may be arranged in the housing for draining the chamber during removal of the cover. A closure device may be arrange in the intermediate piece and have a closure element configured to close the drainage duct.

Abstract: A filter may include a cover defining a chamber and an annular filter element arranged within the chamber. The filter may also include a housing and at least one intermediate piece arranged between the cover and the housing when the cover is screwed to the housing. An inlet duct may be in communication with an untreated side of the filter element and an outlet duct may be in communication with a clean side of the filter element. A drainage duct may be arranged in the housing for draining the chamber during removal of the cover. A closure device may be arrange in the intermediate piece and have a closure element configured to close the drainage duct.

Abstract: A test device and method using a separate control module for test are disclosed, where a main console is replaced with a control module of the test device, the control module may generate a control command after receiving the a command transmitted from the main console, and transmit the control command to at least one PLD corresponding thereto, the PLD may control the GIPO comprised thereby to test the unit under test according to the received control command, whereby reducing the test time and achieving in the effect where the main console may do the other work concurrently when engaging in the test for the unit under test.

Abstract: A filter may include ac over defining a chamber and an annular filter element arranged within the chamber. The filter may also include a housing and at least one intermediate piece arranged between the cover and the housing when the cover is screwed to the housing. An inlet duct may be in communication with an untreated side of the filter element and an outlet duct may be in communication with clean side of the filter side of the filter element and an outlet duct may be in communication with a clean side of the filter element. A drainage duct may be arranged in the housing for draining the chamber during removal of the cover. A closure device may be arranged in the intermediate piece and have a closure element configured to close the drainage duct.

Abstract: A filter may include ac over defining a chamber and an annular filter element arranged within the chamber. The filter may also include a housing and at least one intermediate piece arranged between the cover and the housing when the cover is screwed to the housing. An inlet duct may be in communication with an untreated side of the filter element and an outlet duct may be in communication with clean side of the filter side of the filter element and an outlet duct may be in communication with a clean side of the filter element. A drainage duct may be arranged in the housing for draining the chamber during removal of the cover. A closure device may be arranged in the intermediate piece and have a closure element configured to close the drainage duct.

Abstract: A filter may include a cover defining a chamber and an annular filter element arranged within the chamber. The filter may also include a housing and at least one intermediate piece arranged between the cover and the housing when the cover is screwed to the housing. An inlet duct may be in communication with an untreated side of the filter element and an outlet duct may be in communication with a clean side of the filter element. A drainage duct may be arranged in the housing for draining the chamber during removal of the cover. A closure device may be arrange in the intermediate piece and have a closure element configured to close the drainage duct.