Patents by Inventor Zhang Bao Xu

Zhang Bao Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Structure of protein kinase C theta
    Patent number: 7584087
    Abstract: A three-dimensional structure of human protein kinase C theta (PKC?) can be used in methods of designing an agent that interacts with PKC?. The agent can be an inhibitor of PKC? activity.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: September 1, 2009
    Assignee: Wyeth
    Inventors: Zhang Bao Xu, Stephane Olland, Scott Wolfrom, Karl Malakian, Laura Lin, Mark Stahl, Julie Lee, Lori Fitz, Rita Greco, Divya Chaudhary, William Stuart Somers, Lidia Mosyak
  • Methods for the design of estrogen receptor ligands
    Patent number: 7555415
    Abstract: Estrogen receptor ligands, estrogen receptor polypeptide/ligand complexes, crystals of estrogen receptor polypeptide/ligand complexes, and related methods and software systems are disclosed.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: June 30, 2009
    Assignee: Wyeth
    Inventors: Lidia Mosyak, Zhang Bao Xu, Mark Stahl, Wah-Tung Hum, William Stuart Somers, Eric Steven Manas
  • Crystal structure of estrogen receptor-beta complex and uses thereof
    Publication number: 20080227960
    Abstract: This invention is directed to the crystal structure of Estrogen Receptor-? (ER-?) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-?, which may be useful as novel chemotherapeutic agents.
    Type: Application
    Filed: April 13, 2007
    Publication date: September 18, 2008
    Applicant: Genetics Institute, LLC.
    Inventors: William S. Somers, Zhang-Bao Xu, Tatos N. Akopian, Chu-Lai Hsiao, Rayomand Unwalla
  • Method using crystal structure of estrogen receptor-? complex
    Patent number: 7235367
    Abstract: This invention is directed to the crystal structure of Estrogen Receptor-? (ER-?) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-?, which may be useful as novel chemotherapeutic agents.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: June 26, 2007
    Assignee: Genetics Institute, LLC.
    Inventors: William S. Somers, Zhang-Bao Xu, Tatos N. Akopian, Chu-Lai Hsiao, Rayomand Unwalla
  • Methods for designing agents that interact with MMP-13
    Patent number: 6934639
    Abstract: The present invention relates to the three dimensional structure of human collagenase 3 (MMP-13), as well as to (i) methods of using the MMP-13 structure to rationally design or identify compounds or molecules that inhibit or activate MMP-13 activity, and (ii) compounds identified using said methods.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: August 23, 2005
    Assignee: Wyeth
    Inventors: James M. Chen, Dominick Mobilio, Franklin J. Moy, Kevin D. Parris, Robert Powers, Zhang Bao Xu
  • Crystal structure of estrogen receptor-beta complex and uses thereof
    Publication number: 20020072587
    Abstract: This invention is directed to the crystal structure of Estrogen Receptor-&bgr; (ER-&bgr;) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-&bgr;, which may be useful as novel chemotherapeutic agents.
    Type: Application
    Filed: July 11, 2001
    Publication date: June 13, 2002
    Inventors: William S. Somers, Zhang-Bao Xu, Tatos N. Akopian, Chu-Lai Hsiao, Rayomand Unwalla