Patents by Inventor Zhangyong SI

Zhangyong SI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Beta-peptido sugar-copolymer
    Patent number: 11970576
    Abstract: There is provided a ?-peptido sugar-copolymer having the structure of formula (I) as defined herein, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the same. There is provided a process to make the ?-peptido sugar-copolymer as defined herein. There are further provided medical applications of the ?-peptido sugar-copolymer as defined herein. In a preferred embodiment, a block-like copolymer poly(amido-D-glucose)-block-poly-?-(L)-homolysine (PDGu-b-PBLK) synthesized via anionic ring-opening polymerization (ROP) demonstrates an antimicrobial efficacy, an enhanced selectivity towards different bacteria, biocompatibility vs. mammalian cells and spontaneous assembly.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: April 30, 2024
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Bee Eng Mary Chan, Yu Du, Rubi Zamudio Vazquez, Kaixi Zhang, Zhangyong Si, Yuguang Mu, Hongwei Duan
  • BIODEGRADABLE POLYIMIDAZOLIUMS AND OLIGOIMIDAZOLIUMS
    Publication number: 20230131111
    Abstract: Disclosed herein are compounds in the form of polymers, oligomers and defined molecules having repeating units that all incorporate repeating units formed from an imidazolium group and a biodegradable chain connected to an adjacent repeating unit. The compounds disclosed herein may have antimicrobial activity and so may be used to treat microbial infection and/or to treat surfaces to prevent microbial infections. Also disclosed herein are methods of forming the compounds.
    Type: Application
    Filed: May 25, 2021
    Publication date: April 27, 2023
    Inventors: Bee Eng Mary CHAN, Surendra Hittanahalli MAHADEVEGOWDA, Wenbin ZHONG, Mallikharjuna Rao LAMBU, Jianghua LI, Zhangyong SI
  • CHITOSAN DERIVATIVES AS ANTIMICROBIALS AND SYNERGISTIC COMBINATIONS THEREOF
    Publication number: 20220340689
    Abstract: Disclosed herein is a compound of formula I: where m, n and R1 are as defined herein. Also disclosed herein are uses of the compound.
    Type: Application
    Filed: April 14, 2022
    Publication date: October 27, 2022
    Inventors: Bee Eng Mary Chan, Zhangyong Si, Zheng Hou, Yogesh Shankar Vikhe, Kishore Reddy Venkata Thappeta
  • BETA-PEPTIDO SUGAR-COPOLYMER
    Publication number: 20220332892
    Abstract: There is provided a ?-peptido sugar-copolymer having the structure of formula (I) as defined herein, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the same. There is provided a process to make the ?-peptido sugar-copolymer as defined herein. There are further provided medical applications of the ?-peptido sugar-copolymer as defined herein. In a preferred embodiment, a block-like copolymer poly(amido-D-glucose)-block-poly-?-(L)-homolysine (PDGu-b-PBLK) synthesized via anionic ring-opening polymerization (ROP) demonstrates an antimicrobial efficacy, an enhanced selectivity towards different bacteria, biocompatibility vs. mammalian cells and spontaneous assembly.
    Type: Application
    Filed: January 12, 2018
    Publication date: October 20, 2022
    Inventors: Bee Eng Mary CHAN, Yu DU, Rubi ZAMUDIO VAZQUEZ, Kaixi ZHANG, Zhangyong SI, Yuguang MU, Hongwei DUAN