Abstract: The present invention relates to 18F-labeled compounds suitable for positron emission tomography (PET) imaging. The invention further relates to the use of these compounds for carrying out PET scans, imaging the indoleamine 2,3-dioxygenase, pathway, predicting the responsiveness of a subject with a solid tumor to therapies including immunotherapy such as PD-1/PD-L1 inhibition, and determining whether a solid tumor in a subject contains tumor-infiltrating immune cells.

Abstract: Conformationally strained irans-cycloalkenes and derivatives thereof suitable for radiolabeling in a subject in need thereof.

Abstract: A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group.

Abstract: The present invention relates to 18F-labeled compounds suitable for positron emission tomography (PET) imaging. The invention further relates to the use of these compounds for carrying out PET scans, imaging the indoleamine 2,3-dioxygenase, pathway, predicting the responsiveness of a subject with a solid tumor to therapies including immunotherapy such as PD-1/PD-L1 inhibition, and determining whether a solid tumor in a subject contains tumor-infiltrating immune cells.

Abstract: A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group.

Abstract: A repository server system supports one-click retrieval of user data over a communications network in fulfillment of the data requirements of a Web page form served to a user computer system by a Web page server. The repository server system includes a data store that stores user data. The repository server system provides the Web page form with a clickable user interface control to the user computer system. The control encompasses a user data request, issuable by the user computer system and that corresponds to the Web page form. The repository server system is responsive to the user data request to provide a user data response, corresponding to the user data request, to the user computer system.

Abstract: A repository server system supports a user in submission of confidential user information through client Web page forms served to user computer systems. A data store contains user data referenceable by a first set of names. The repository server processor is coupled to the data store and coupleable to a communications network to receive a user data request from a user computer system, where the user data request includes a client specification of the user data requested to complete the client Web page form. The client specification identifies user data by a second set of names. The processor provides for the conversion of user data stored in correspondence with the first set of names to a form corresponding with the second set of names.

Abstract: A repository server system stores confidential user-information for selective distribution, on behalf of a user to third-party server systems to enable autonomous form data fill-in of form fields having third-party server defined data formats. A database stores the confidential user-information data in named data fields. A repository server processor is coupleable to the database to access the confidential user-information. The processor is coupleable to a communications network to receive a form data request from a form served by the third-party server. The form data request includes a predefined selective mapping of named form fields relative to the named data fields. The processor operates over the selective mapping to access the confidential user-information data and produce instances of the confidential user-information data corresponding to the defined data formats of the named form fields.

Abstract: A Web site is integrated with an information repository server storing user-information to provide for the selective submission of user-information to the Web site. A form Web page deployable by the Web site is first prepared by establishing a specification of user-information needed to complete the form Web page for a given user. The Web page is then coded to issue a request including the specification to the information repository server in response to a predetermined user action. The specification is evaluable by the information repository server to determine a mapping between user-information requested by the Web page and the user-information stored by the information repository server for the user. The Web page is then deployed for retrieval by the user. When the specification is subsequently evaluated, mapping and conversion functions are applied, specific to the user-information stored for a particular user, to return data for completion of the form Web page.