Abstract: A locking mechanism includes: a mounting housing; a shaft sleeve rotatably arranged on the mounting housing and having an inner wall provided with a first snap structure; a locking assembly, at least a part of the locking assembly being movably arranged in the shaft sleeve, and the locking assembly being provided with a second snap structure cooperating with the first snap structure; and a driving member, at least a part of the driving member being movably arranged on and passing through the mounting housing, wherein the driving member is in driving connection with at least a part of the locking assembly, and the driving member drives the second snap structure to be snapped with or separated from the first snap structure.

Abstract: The present disclosure is directed to binding proteins to the extracellular domain (ECD) of HER2/ErbB2. More particularly, the binding proteins bind to a conformational epitope which is exposed in cells in response to HER2 amplification or activation.

Abstract: The present disclosure provides a locking mechanism and a vehicle having the same. The locking mechanism includes: a mounting housing; a shaft sleeve rotatably arranged on the mounting housing and having an inner wall provided with a first snap structure; a locking assembly, at least a part of the locking assembly being movably arranged in the shaft sleeve, and the locking assembly being provided with a second snap structure cooperating with the first snap structure; and a driving member, at least a part of the driving member being movably arranged on and passing through the mounting housing, wherein the driving member is in driving connection with at least a part of the locking assembly, and the driving member drives the second snap structure to be snapped with or separated from the first snap structure.

Abstract: This invention provides anti-idiotype antibodies specific for Anti-Lewis Y monoclonal antibodies. The present invention also directed against an ELISA screening method of mAbs produced by hybridoma clones for specific binding to the variable regions of hu3S193 and the ability of the anti-idiotypic mAB to inhibit hu3S193 binding to Lewis Y antigen. Additionally, the present invention provides a hybridoma capable of producing an anti-idiotype antibody specific for anti-Lewis Y monoclonal antibody. A further aspect of the invention is to provide a hybridoma, which is specific for anti-Lewis Y monoclonal antibody selected from the group consisting of LMH-1, LMH-2, LMH-3, or LMH-4. The present invention is also directed against a method to detect HAMA, HACA and HAHA responses using the antibody of the invention.