Abstract: Provided are a method and an apparatus for laser quenching. The method utilizes a scanning galvanometer, and involves laser quenching via irradiation with intermittent, repeated scans, rather than a single scan as in the prior art. The method results in increased laser energy absorbed by the metal base and improved depth of thermal conduction, while avoiding melting at the metal surface, thus providing a significantly improved laser quenching process. The apparatus can include a laser, a control system, a light guiding system, a mechanical motion device and a galvanometer.

Abstract: Provided are a method and an apparatus for laser quenching. The method takes the advantage of a high jumping speed of a scanning galvanometer, and adopts the method of heating on multiple or even high frequency repeated scans instead of on a single scan in prior art for laser quenching, wherein the laser energy is fed into the surface of a workpiece by way of short time and multiple superimposed heating, cumulatively, the laser energy absorbed by the metal base is increased and the depth of thermal conduction is improved also. The apparatus includes a laser, a control system, a light guiding system, a mechanical motion device and a scanning galvanometer.

Abstract: The invention provides assays and methods for determining the substrate specificity of gamma secretase inhibitors and for identifying substrate-selective (and substrate isoform-selective) inhibitors of gamma secretase. The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a site specific or substrate specific manner. The invention provides isolated polypeptide sequences comprising modified gamma secretase substrates, and polynucleotide sequences encoding the polypeptide sequences. The invention also provides compounds that inhibit gamma secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds.

Abstract: The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a substrate specific manner. The invention provides an isolated cell wherein the cell stably expresses APP and at least one gamma secretase substrate other than APP. The invention provides assays and methods comprising contacting a cell with gamma secretase and detecting production of Abeta, detecting production of intracellular domain (ICD), and detecting a signal from a reporter gene under transcriptional control of the ICD. The invention also provides compounds that inhibit gamma secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds.

Abstract: The invention provides assays and methods for determining the substrate specificity of gamma secretase inhibitors and for identifying substrate-selective (and substrate isoform-selective) inhibitors of gamma secretase. The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a site specific or substrate specific manner. The invention provides isolated polypeptide sequences comprising modified gamma secretase substrates, and polynucleotide sequences encoding the polypeptide sequences. The invention also provides compounds that inhibit gamma secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds.

Abstract: A tape-like heat sink is disclosed. The heat sink is characterized in that a base section which is flexural is mounted to the heat sink, and the base is matrix distribution of protrusions for heat dissipation, and each of the protrusions is provided with a thin layer, thereby the thin film is conveniently flexural for heat dissipation.