Abstract: Methods and apparatuses for generating ortho-restorative treatment plans and orthodontic aligners. The ortho-restorative treatment plan may include prescribed movements of one or more teeth to correct mal-positioned teeth while accounting for planned restorative treatments on a patient's dentition. The methods may include forming a virtual target dentition model having a target restorative feature, and one or more virtual intermediate dentition models having one or more intermediate restorative features having a different shape and/or size as the target restorative feature. The methods may be used generate a series of aligners in accordance with the ortho-restorative treatment plan.

Abstract: Systems, computer-implemented methods, and computer program products to facilitate employing a probabilistic model to generate a continuous disease status index based on observational data are provided. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise a model component that employs a probabilistic model to generate probability distributions of disease states of a disease of an entity based on observational data of the entity. The computer executable components can further comprise an index component that generates a disease status index of the disease based on the probability distributions of the disease states.

Abstract: Systems, computer-implemented methods, and/or computer program products to facilitate updating, such as averaging and/or training, of one or more statistical sets are provided. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can include a computing component that updates a first statistical set with an additional statistical set from an additional system. The additional statistical set can have been generated from a parent statistical set that is based on underlying data. To update the first statistical set, the additional statistical set can be obtained by the system without obtaining the parent statistical set and without obtaining the underlying data. According to an embodiment, the first statistical set can be a model parameter set generated from a first parent statistical set that is an analytical model.

Abstract: Techniques are described that facilitate determining potential cancer gene therapy targets by joint modeling of cancer survival events. In one embodiment, a computer-implemented comprises employing, by a device operatively coupled to a processor, a multi-task learning model to determine active genetic factors respectively associated with different types of cancer based on cancer survival data and patient genomic data for groups of patients that respectively survived the different types of cancer. The computer-implemented method further comprises, determining, by the device, common active genetic factors of the active genetic factors that are shared between two or more types of cancer of the different types of cancer.

Abstract: A system (or method) for generation and employment of disease progression model(s) that facilitates identifying and indexing discriminative features for disease progression in observational data. The disease progression prediction system comprises a processor that executes computer executable components stored in memory. A receiving component receives and learns observational patient data. A model generation component builds a preliminary disease progression model. An identification component identifies discriminative clinical features for different disease stages. A ranking component ranks discriminative powers of clinical features for respective pairs of disease stages; wherein the model generation component employs the ranked features to generate a final disease progression model.

Abstract: A system (or method) for generation and employment of disease progression model(s) that facilitates identifying and indexing discriminative features for disease progression in observational data. The disease progression prediction system comprises a processor that executes computer executable components stored in memory. A receiving component receives and learns observational patient data. A model generation component builds a preliminary disease progression model. An identification component identifies discriminative clinical features for different disease stages. A ranking component ranks discriminative powers of clinical features for respective pairs of disease stages; wherein the model generation component employs the ranked features to generate a final disease progression model.

Abstract: A dental attachment placement device comprises a plurality of articulated registration elements shaped for placement on a plurality of teeth, which can facilitate placement, accommodate tooth movement, and improve alignment of the registration elements with the teeth, so as to accurately position an attachment for placement. An orthodontic device may include a plurally of registration element. A plurality of first flexible arms may extend from each registration element on a lingual side. The first flexible arm may have a connected end and a distal end. The distal end may be configured to extend at least part way over the tooth and apply a lingual force to bias the registration element against the tooth. A plurality of attachment supports may each be located on a buccal side of the plurally of registration elements and include an attachment frame that is releasably coupled to an attachment.

Abstract: A dental attachment placement device comprises a plurality of registration elements shaped for placement on a plurality of teeth and one or more flexible arms for biasing the registration element to a tooth. A first a first flexible arm may extend from a registration element on a lingual side. The first flexible arm may have a connected end and a distal end. The distal end may be configured to extend at least part way over the tooth and apply a lingual force to bias the registration element against the tooth.

Abstract: A dental attachment placement device comprises a plurality of articulated registration elements shaped for placement on a plurality of teeth, which can facilitate placement, accommodate tooth movement, and improve alignment of the registration elements with the teeth, so as to accurately position an attachment for placement. The plurality of registration elements may comprise one or more attachment supports and one or more retention supports extending from the plurality of registration elements. A dental attachment can be removably coupled to the attachment support. The plurality of registration elements and attachment supports may be located on opposing sides of one or more teeth in order to maintain placement prior to adhering the attachment to the tooth. In some embodiments, each of the plurality of registration elements comprises a tooth registration surface shaped to engage the tooth with a specific position and orientation for accurate positioning of the attachment.

Abstract: Systems, computer-implemented methods, and computer program products to facilitate employing a probabilistic model to generate a continuous disease status index based on observational data are provided. According to an embodiment, a system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise a model component that employs a probabilistic model to generate probability distributions of disease states of a disease of an entity based on observational data of the entity. The computer executable components can further comprise an index component that generates a disease status index of the disease based on the probability distributions of the disease states.

Abstract: Predicting beneficial drug combinations mitigating adverse drug reactions identifies drug combinations and associated target adverse drug reaction from a spontaneous reporting system containing case reports of drugs and associated adverse drug reactions. Each drug combination comprises a first drug and a second drug, and a propensity score is computed for each drug in each group. This propensity score expresses a probability of being exposed to a given drug based on other co-prescribed drugs and reported indications, which reflect patient characteristics. Associations are computed for each drug as well as drug interaction. Among the associations, the sum of the associations of the second drug and the interaction effect represents the predicted beneficial score expressing whether the second drug alters the chance of developing the target adverse drug reaction for patients on the first drug.

Abstract: A method, system, and computer program product, include obtaining a plurality of training sets of samples and a plurality of testing sets of samples from a data set of clinical records, the plurality of training sets of samples and the corresponding plurality of testing sets of samples including different samples of the data set, determining statistical significance for a plurality of risk factors of a model from the plurality of training sets of samples, determining a plurality of performance metrics of the model from the plurality of testing sets of samples, and determining an evaluation metric of the plurality of risk factors for the model based on the statistical significance and the plurality of performance metrics, the evaluation metric being for improving accuracy of the model.

Abstract: An embodiment of the invention receives input including a list of drugs, drug characteristics of each drug, and known drug-disease associations including a disease and a drug having a threshold efficacy for treating the disease. For each drug in the list of drugs, a processor predicts whether the drug meets a threshold efficacy for treating a first disease based on the drug characteristics and the drug-disease associations. For each drug in the list of drugs, the processor predicts whether the drug meets a threshold efficacy for treating a second disease based on the drug characteristics and the predicting of whether the drug meets the threshold efficacy for treating the first disease. Output is generated output based on the predictions, the output including an identified drug-disease association, an identified disease-disease association, an identified chemical fingerprint for the first disease, and an identified chemical fingerprint for the second disease.

Abstract: Predicting beneficial drug combinations mitigating adverse drug reactions identifies drug combinations and associated target adverse drug reaction from a spontaneous reporting system containing case reports of drugs and associated adverse drug reactions. Each drug combination comprises a first drug and a second drug, and a propensity score is computed for each drug in each group. This propensity score expresses a probability of being exposed to a given drug based on other co-prescribed drugs and reported indications, which reflect patient characteristics. Associations are computed for each drug as well as drug interaction. Among the associations, the sum of the associations of the second drug and the interaction effect represents the predicted beneficial score expressing whether the second drug alters the chance of developing the target adverse drug reaction for patients on the first drug.

Abstract: An apparatus, method and computer program product for proactive comprehensive generic risk screening. The method performs proactive comprehensive generic risk screening by implementing steps of training comprising steps of receiving cross domain risks and features, optimizing linkage regularization using the received features and the received cross domain risks, said linkage regularization comprising multi-task predictive model training, feature selection and ranking, risk association learning and risk association selection, and outputting patient risk scores, identified high risk patients, risk factors for risks and risk groups, and risk groups and risk associations and calculating risk score for an individual patient comprising steps of receiving individual features comprising patient information, performing said linkage regularization using the received individual features and outputting patient risk scores for said individual patient, and high risk for said individual patient.

Abstract: Techniques are described that facilitate determining potential cancer gene therapy targets by joint modeling of cancer survival events. In one embodiment, a computer-implemented comprises employing, by a device operatively coupled to a processor, a multi-task learning model to determine active genetic factors respectively associated with different types of cancer based on cancer survival data and patient genomic data for groups of patients that respectively survived the different types of cancer. The computer-implemented method further comprises, determining, by the device, common active genetic factors of the active genetic factors that are shared between two or more types of cancer of the different types of cancer.

Abstract: Predicting beneficial drug combinations mitigating adverse drug reactions identifies drug combinations and associated target adverse drug reaction from a spontaneous reporting system containing case reports of drugs and associated adverse drug reactions. Each drug combination comprises a first drug and a second drug, and a propensity score is computed for each drug in each group. This propensity score expresses a probability of being exposed to a given drug based on other co-prescribed drugs and reported indications, which reflect patient characteristics. Associations are computed for each drug as well as drug interaction. Among the associations, the sum of the associations of the second drug and the interaction effect represents the predicted beneficial score expressing whether the second drug alters the chance of developing the target adverse drug reaction for patients on the first drug.

Abstract: A system (or method) for generation and employment of disease progression model(s) that facilitates identifying and indexing discriminative features for disease progression in observational data. The disease progression prediction system comprises a processor that executes computer executable components stored in memory. A receiving component receives and learns observational patient data. A model generation component builds a preliminary disease progression model. An identification component identifies discriminative clinical features for different disease stages. A ranking component ranks discriminative powers of clinical features for respective pairs of disease stages; wherein the model generation component employs the ranked features to generate a final disease progression model.

Abstract: Embodiments describing an approach to receiving patient registry data and creating at least one control model based on the patient registry data. Transforming patient registry data into at least one prediction confident interval based on the at least one control model. Transforming the at least one prediction confident interval into at least one robust assessment score, and outputting the at least one robust assessment score for measuring disease progression indicators.

Abstract: A method, system, and computer program product, include obtaining a plurality of training sets of samples and a plurality of testing sets of samples from a data set of clinical records, the plurality of training sets of samples and the corresponding plurality of testing sets of samples including different samples of the data set, determining statistical significance for a plurality of risk factors of a model from the plurality of training sets of samples, determining a plurality of performance metrics of the model from the plurality of testing sets of samples, and determining an evaluation metric of the plurality of risk factors for the model based on the statistical significance and the plurality of performance metrics, the evaluation metric being for improving accuracy of the model.