Patents by Inventor Zhaoxiang BIAN

Zhaoxiang BIAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160367498
    Abstract: The present invention relates to a method of using trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 22, 2016
    Inventors: Zhaoxiang BIAN, Siu Wai TSANG, Hongjie ZHANG, Aiping LU, Albert Sun-Chi CHAN
  • Publication number: 20160368890
    Abstract: This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds.
    Type: Application
    Filed: June 18, 2015
    Publication date: December 22, 2016
    Inventors: Zhaoxiang BIAN, Chengyuan LIN, Huaixue MU, Baomin FAN, Yongyun ZHOU, Jingchao CHEN, Aiping LU, Albert Sun-Chi CHAN
  • Patent number: 9408811
    Abstract: Prostate cancer is the most commonly diagnosed cancer in males and one of the leading causes of cancer death. Although treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. This invention relates to a method for treating cancer comprising using an anti-cancer compound of formula (I): More particularly, it relates to said anti-prostate cancer compound that can be isolated from Garcinia esculenta or chemically synthesized and its specific anticancer/antitumor activity. The invention has a specific application in treating human prostate cancer.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: August 9, 2016
    Assignee: Hong Kong Baptist University
    Inventors: Hongxi Xu, Xin Li, Hong Zhang, Yuanzhi Lao, Hongsheng Tan, Xiaoyu Wang, Kaixian Chen, Zhaoxiang Bian, Dajian Yang, Shilin Chen, Aiping Lu, Albert Sun Chi Chan
  • Patent number: 9408828
    Abstract: The present invention provides a compound, namely (+)-3?-Angeloyloxy-4?-keto-3?,4?-dihydroseselin (Pd-Ib) derived from Bupleurum malconense as the potential anti-inflammation drug. The present invention also relates to methods of preparing the compounds and using the same for treating inflammation.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: August 9, 2016
    Inventors: Zhaoxiang Bian, Huaixue Mu, Chengyuan Lin, Quanbin Han, Aiping Lu, Linfang Huang, Shilin Chen, Dajian Yang, Hongxi Xu, Sun Chi Albert Chan
  • Publication number: 20160185744
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt, hydrate or prodrug thereof for inhibiting Syk activity,
    Type: Application
    Filed: August 12, 2015
    Publication date: June 30, 2016
    Inventors: Hongxi XU, Yue LV, Wenwei FU, Kaixian CHEN, Zhaoxiang BIAN, Shilin CHEN, Dajian YANG, Aiping LU, Sun Chi Albert CHAN
  • Patent number: 9339488
    Abstract: Cervical cancer is one of the most common malignancies and is associated with a dismal prognosis. The most common therapeutic option for cervical cancer consists of surgery in early stages, and chemotherapy or radiotherapy in more advanced stages of the disease. Although treatment options have increased for some patients, overall progress has been modest. This invention relates to a method for treating cancer comprising administering an anti-cancer compound. More particularly, the present invention relates to an anti-cervical-cancer compound for treating human cervical cancer and tumor.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: May 17, 2016
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Hongxi Xu, Hong Zhang, Yuanzhi Lao, Xiaoyu Wang, Kaixian Chen, Dajian Yang, Shilin Chen, Chengyuan Lin, Zhaoxiang Bian, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20160074324
    Abstract: The present invention provides a slow and controlled released liposomal gel composition for subcutaneous administration comprises insulin or exenatide as active ingredient for reduction of blood sugar level and method of preparation thereof. Said controlled released composition has high bioavailability and is demonstrated to be able to sustain release therapeutically effective concentration of drug over a period of time and without rapid release of drug after initial administration. Method of preparing the controlled released composition of the present invention comprises the following steps: mixing insulin or exenatide, lipid and aqueous dispersion medium together; then mixing with poloxamer (e.g. F127 or P123) and/or gelatin and hyaluronic acid (HA) or the like gel solution so as to form a protective layer on surface of every lipid micro vesicles or nano-vesicles for use in intramuscular, abdominal and subcutaneous administration.
    Type: Application
    Filed: October 20, 2014
    Publication date: March 17, 2016
    Applicant: Hong Kong Baptist University
    Inventors: Zhijun YANG, Aiping LU, Zhaoxiang BIAN, Xiaoyu CHEN, Blenda Chi Kwan WONG
  • Patent number: 9260466
    Abstract: A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from Pronephrium penangianum.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: February 16, 2016
    Assignee: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Hongjie Zhang, Yegao Chen, Aiping Lu, Albert Sun-Chi Chan, Hongxi Xu, Shilin Chen, Dajian Yang
  • Publication number: 20150366841
    Abstract: The present invention provides a compound, namely (+)-3?-Angeloyloxy-4?-keto-3?, 4?-dihydroseselin (Pd-Ib) derived from Bupleurum malconense as the potential anti-inflammation drug. The present invention also relates to methods of preparing the compounds and using the same for treating inflammation.
    Type: Application
    Filed: June 18, 2015
    Publication date: December 24, 2015
    Inventors: Zhaoxiang BIAN, Huaixue MU, Chengyuan LIN, Quanbin HAN, Aiping LU, Linfang HUANG, Shilin CHEN, Dajian YANG, Hongxi XU, Sun Chi Albert CHAN
  • Patent number: 9120816
    Abstract: The present invention relates to chemical entities originated from natural sources and further synthesized for therapeutic uses. More particularly, the present invention relates to norcantharidin analogs synthesized by a transition metal-catalyzed alkynylation of oxanorbornadiene derivatives and their antitumor effects.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: September 1, 2015
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Zhaoxiang Bian, Chengyuan Lin, Baomin Fan, Huaixue Mu, Yongyun Zhou, Weimin Zeng, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20150231090
    Abstract: The present invention provides composition for treating cancer comprising polyprenylated acylphloroglucinol (PPAP) compound. The present invention also provides a composition comprising Guttiferone K for treating esophageal cancer and liver cancer. The present invention further provides a method of using said compound for inhibiting cancer metastasis.
    Type: Application
    Filed: May 1, 2015
    Publication date: August 20, 2015
    Inventors: Hongxi XU, Kaikai SHEN, Yuanzhi LAO, Hongsheng TAN, Kaixian CHEN, Dajian YANG, Shilin CHEN, Zhaoxiang BIAN, Chengyuan LIN, Aiping LU, Albert Sun Chi CHAN
  • Publication number: 20150196612
    Abstract: The present invention discloses a novel composition with anti-viral effects comprises extracts from Anemarrhena asphodeloides. Method of preparing said extract is also disclosed.
    Type: Application
    Filed: January 10, 2014
    Publication date: July 16, 2015
    Applicants: Shanghai University of Traditional Chinese Medicine, Hong Kong Baptist University
    Inventors: Quanbin HAN, Aiping LU, Zhaoxiang BIAN, Hongxi XU, Mengshun LIU, Ling TAO, Mengjie WANG, Kaixian CHEN
  • Patent number: 9044502
    Abstract: This invention relates to a Chinese medicinal formulation for the treatment of inflammatory bowel diseases, and a method of preparation thereof. The formulation comprises herbal components selected from a group consisting of Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Bai Zhu), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Zingiberis Officinalis (Gan Jiang), Radix Paeoniae Alba (Bai Shao) and Rhizoma Coptidis (Huanglian).
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: June 2, 2015
    Assignee: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Siu Po Ip, Che Yuen Justin Wu, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20150079128
    Abstract: This invention relates to a Chinese medicinal formulation for the treatment of inflammatory bowel diseases, and a method of preparation thereof. The formulation comprises herbal components selected from a group consisting of Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Bai Zhu), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Zingiberis Officinalis (Gan Jiang), Radix Paeoniae Alba (Bai Shao) and Rhizoma Coptidis (Huanglian).
    Type: Application
    Filed: September 18, 2013
    Publication date: March 19, 2015
    Applicant: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Siu Po Ip, Che Yuen Justin Wu, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20150038569
    Abstract: Cervical cancer is one of the most common malignancies and is associated with a dismal prognosis. The most common therapeutic option for cervical cancer consists of surgery in early stages, and chemotherapy or radiotherapy in more advanced stages of the disease. Although treatment options have increased for some patients, overall progress has been modest. This invention relates to a method for treating cancer comprising administering an anti-cancer compound. More particularly, the present invention relates to an anti-cervical-cancer compound for treating human cervical cancer and tumor.
    Type: Application
    Filed: July 31, 2014
    Publication date: February 5, 2015
    Inventors: Hongxi XU, Hong ZHANG, Yuanzhi LAO, Xiaoyu WANG, Kaixian CHEN, Dajian YANG, Shilin CHEN, Chengyuan LIN, Zhaoxiang BIAN, Aiping LU, Albert Sun Chi CHAN
  • Publication number: 20150025155
    Abstract: Prostate cancer is the most commonly diagnosed cancer in males and one of the leading causes of cancer death. Although treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. This invention relates to a method for treating cancer comprising using an anti-cancer compound. More particularly, it relates to an anti-prostate cancer compound that can be isolated from Garcinia esculenta or chemically synthesized and its specific anticancer/antitumor activity. The invention has a specific application in treating human prostate cancer.
    Type: Application
    Filed: July 17, 2014
    Publication date: January 22, 2015
    Inventors: Hongxi XU, Xin LI, Hong ZHANG, Yuanzhi LAO, Hongsheng TAN, Xiaoyu WANG, Kaixian CHEN, Zhaoxiang BIAN, Dajian YANG, Shilin CHEN, Aiping LU, Albert Sun Chi CHAN
  • Publication number: 20150011646
    Abstract: This invention is related to compounds isolated from various Garcinia species and method of treating cancer. The present invention provides composition for treating cancer comprising polyprenylated acylphloroglucinol (PPAP) compound. The present invention also provides a composition comprising Guttiferone K for treating esophageal cancer.
    Type: Application
    Filed: January 8, 2014
    Publication date: January 8, 2015
    Applicant: Hong Kong Baptist University
    Inventors: Hongxi XU, Yuanzhi LAO, Zhichao XI, Hongsheng TAN, Kaixian CHEN, Zhaoxiang BIAN, Dajian YANG, Shilin CHEN, Aiping LU, Albert Sun Chi CHAN
  • Publication number: 20140348965
    Abstract: A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from Pronephrium penangianum.
    Type: Application
    Filed: May 22, 2013
    Publication date: November 27, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Hongjie Zhang, Yegao Chen, Aiping Lu, Albert Sun-Chi Chan, Hongxi Xu, Shilin Chen, Dajian Yang
  • Patent number: 8835658
    Abstract: The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: September 16, 2014
    Assignees: Hong Kong Baptist University, Yunnan University of Nationalities
    Inventors: Albert Sun-Chi Chan, Baomin Fan, Jun Wang, Chengyuan Lin, Chao Huang, Qingjing Yang, Jianbin Xu, Zhaoxiang Bian, Aiping Lu, Jun Hu
  • Publication number: 20140235877
    Abstract: The present invention provides two compounds, namely Compound A and B, as the potential anticancer drug, and a composition comprising said Compound A and/or B for treating cancer or tumor related diseases. The present invention also relates to methods of preparing the compounds from a natural source and a composition comprising the compounds, and using the same for treating cancer or tumor related diseases.
    Type: Application
    Filed: March 31, 2014
    Publication date: August 21, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Hongxi XU, Zhengxiang XIA, Yuanzhi LAO, Hongsheng TAN, Zhaoxiang BIAN, Dajian YANG, Shilin CHEN, Kaixian CHEN, Albert Sun-Chi CHAN