Patents by Inventor Zhaoxing YU

Zhaoxing YU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • One-pot process for preparing intermediate of antibody-drug conjugate
    Patent number: 11717575
    Abstract: The present invention relates to a “one-pot process” for preparing intermediate of antibody-drug conjugate. The preparation process provided by the present invention is simple in operation, and needs no such steps like concentration, washing and filtration of the intermediate reaction liquid, disposal of the organic waste liquid, and packaging and storage of the intermediate. The entire reaction system comprises only one separation and purification treatment, saving costs for labor, equipment, venues, raw materials, etc., and greatly reducing the pollution to the environment. In addition, the “one-pot process” for preparing intermediate of antibody-drug conjugate of the present invention produces the intermediate of antibody-drug conjugate with higher yield. The “one-pot process” for preparing intermediate of antibody-drug conjugate provided by the present invention is more suitable for scale-up production.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: August 8, 2023
    Assignee: MABPLEX INTERNATIONAL CO., LTD.
    Inventors: Zhaoxing Yu, Xinfang Li, Mingchao Lan, Xinjie Mao
  • ONE-POT PROCESS FOR PREPARING INTERMEDIATE OF ANTIBODY-DRUG CONJUGATE
    Publication number: 20210085799
    Abstract: The present invention relates to a “one-pot process” for preparing intermediate of antibody-drug conjugate. The preparation process provided by the present invention is simple in operation, and needs no such steps like concentration, washing and filtration of the intermediate reaction liquid, disposal of the organic waste liquid, and packaging and storage of the intermediate. The entire reaction system comprises only one separation and purification treatment, saving costs for labor, equipment, venues, raw materials, etc., and greatly reducing the pollution to the environment. In addition, the “one-pot process” for preparing intermediate of antibody-drug conjugate of the present invention produces the intermediate of antibody-drug conjugate with higher yield. The “one-pot process” for preparing intermediate of antibody-drug conjugate provided by the present invention is more suitable for scale-up production.
    Type: Application
    Filed: February 13, 2020
    Publication date: March 25, 2021
    Applicant: MABPLEX INTERNATIONAL, LTD.
    Inventors: Zhaoxing YU, Xinfang LI, Mingchao LAN, Xingie Mao