Abstract: A pyrimidine-2,4-diamine compound and a preparation method and application thereof are provided. The pyrimidine-2,4-diamine compound of the present disclosure can be used in the research of biological or pharmacological phenomena and cathepsin C-involved signal pathway transduction and the evaluation of novel cathepsin C inhibitors. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-cathepsin C activity in vitro and in vivo and proved to have strong inhibitory activity on cathepsin C. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-NSP activity in vivo and proved to have strong inhibitory activity on NSP. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-inflammatory activity in vivo and proved to have an effective therapeutic effect on inflammatory disease models. Meanwhile, the pyrimidine-2,4-diamine compound shows low toxicity and exhibits good application prospect.

Abstract: A method and apparatus for mitigating blast compression waves is disclosed. The apparatus has a housing having an open end, and a piston slidably received in the open end of the housing in a substantially airtight engagement therewith. The piston and the housing define an interior wherein a compressible substance is confined. When a blast wave impacts the impact face of the piston and drives the piston toward the base of the housing, a shock wave is induced in the compressible substance. The shock wave is reflected by the base of the enclosure and the interior surface of the piston to mitigate the impact of the blast wave.