Patents by Inventor Zhaoyang Li
Zhaoyang Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240139220Abstract: A pharmaceutically acceptable salt of an acyclic nucleotide phosphoramidate to treat HPV and related conditions including neoplasia, as well as pharmaceutical compositions, morphic forms and dosage forms thereof.Type: ApplicationFiled: October 31, 2023Publication date: May 2, 2024Applicant: Antiva Biosciences, Inc.Inventors: Barry Aldous, Ramakrishna Gadiraju, Sarah Walter, Oranee Daniels, Gail Maderis, Ankush Argade, Ravichandran Mahalingam, Zhengle Zhao, Zhaoyang Qin, Siyi Jiang, Runyan Li
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Publication number: 20240139221Abstract: A pharmaceutically acceptable salt of an acyclic nucleotide phosphoramidate to treat HPV and related conditions including neoplasia, as well as pharmaceutical compositions, morphic forms and dosage forms thereof.Type: ApplicationFiled: October 31, 2023Publication date: May 2, 2024Applicant: Antiva Biosciences, IncInventors: Barry Aldous, Ramakrishna Gadiraju, Sarah Walter, Oranee Daniels, Gail Maderis, Ankush Argade, Ravichandran Mahalingam, Zhengle Zhao, Zhaoyang Qin, Siyi Jiang, Runyan Li
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Patent number: 11970479Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.Type: GrantFiled: October 24, 2019Date of Patent: April 30, 2024Assignees: Merck Sharp & Dohme LLC, MSD R&D (China) Co. LTD.Inventors: John J. Acton, III, Melissa Egbertson, Xiaolei Gao, Scott T. Harrison, Timothy J. Henderson, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Zhaoyang Meng, James Mulhearn, Vanessa L. Rada, Jeffrey W. Schubert, Oleg B. Selyutin, David M. Tellers, Ling Tong, Fengqi Zhang, Jianming Bao, Chunsing Li
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Patent number: 11946345Abstract: A device and a method for experimental exploitation of natural gas hydrates in full-sized production wells are provided. The device includes a full-diameter well, and the full-diameter well includes a heating circulation tube, a temperature sensor tube, an upper sealing unit and a lower sealing unit. Perforations are provided along a body of the full-diameter well. A reactor includes an upper cover, a lower cover, and a reactor body. The method is conducted by using the device and the reactor. The device and method allow simulation of sand-control wellbores in actual exploitation of natural gas hydrates, and realize horizontal and vertical sand-control experiments.Type: GrantFiled: September 8, 2020Date of Patent: April 2, 2024Assignee: GUANGZHOU INSTITUTE OF ENERGY CONVERSION, CHINESE ACADEMY OF SCIENCESInventors: Xiaosen Li, Zhaoyang Chen, Yi Wang, Zhiming Xia, Gang Li, Yu Zhang
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Patent number: 11948693Abstract: The present disclosure provides a traditional Chinese medicine (TCM) syndrome classification method based on multi-graph attention, which comprehensively considers the contribution of symptoms and syndrome elements in syndrome classification by constructing a graph structure, integrates a symptom-symptom graph and a symptom-syndrome element graph into classification, uses a multi-graph attention network to aggregate the features of symptoms and syndrome elements, and finally realizes syndrome classification through a multi-layer perceptron. At the same time, extensive experiments are carried out on real data sets, the effectiveness of the multi-graph attention network is verified, more accurate classification is realized, and better classification results have been achieved.Type: GrantFiled: June 20, 2023Date of Patent: April 2, 2024Assignee: NANJING DAJING TCM INFORMATION TECHNOLOGY CO. LTDInventors: Jing Zhao, Wenyou Li, Zhaoyang Jiang, Jie Yin, Ying Chen
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Patent number: 11942020Abstract: Disclosed is a driving circuit including an input circuit, a first output circuit, a second output circuit and a pull-down circuit. Control terminals of the first output circuit and the second output circuit are connected with an output terminal of the input circuit and receive a control signal from the input circuit, and output terminals of the first output circuit and the second output circuit are connected with the pull-down circuit and receive a pull-down signal. Thus, two stages of driving signals output by one stage driving circuit is realized. As compared with the existing architecture under which the two stage driving circuit is needed to output two stages of driving signals, one input circuit and one pull-down circuit are removed. This application also discloses a four-stage driving circuit and a display panel. The number of used components is reduced, and the frame of the display product is narrowed.Type: GrantFiled: July 29, 2022Date of Patent: March 26, 2024Assignee: HKC CORPORATION LIMITEDInventors: Byung Hoon Kim, Zhaoyang Lu, Sahng Ik Jun, Rongrong Li
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Patent number: 11935158Abstract: A method for performing real-time magnetic resonance (MR) imaging on a subject is disclosed. A prep pulse sequence is applied to the subject to obtain a high-quality special subspace, and a direct linear mapping from k-space training data to subspace coordinates. A live pulse sequence is then applied to the subject. During the live pulse sequence, real-time images are constructed using a fast matrix multiplication procedure on a single instance of the k-space training readout (e.g., a single k-space line or trajectory), which can be acquired at a high temporal rate.Type: GrantFiled: May 4, 2021Date of Patent: March 19, 2024Assignee: Cedars-Sinai Medical CenterInventors: Anthony Christodoulou, Zhaoyang Fan, Debiao Li, Pei Han
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Publication number: 20240044793Abstract: A method, system and storage medium for providing an alarm for indicating that an abnormality is present in a sample analyzer are provided. The method includes: mixing a first aliquot of a blood sample with a diluent agent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample; detecting at least two types of optical signals of the second test sample; acquiring first platelet detection data based on the electrical impedance signals; acquiring second platelet detection data based on the at least two types of optical signals; acquiring an evaluation result based on a difference between the first platelet detection data and the second platelet detection data; determining whether the evaluation result meets a preset condition to provide an alarm.Type: ApplicationFiled: October 9, 2023Publication date: February 8, 2024Inventors: Huan QI, Wenbo ZHENG, Bo YE, Zhaoyang LI, Yi YE
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Patent number: 11874212Abstract: A blood analysis method, a blood analysis system, and a storage medium are provided. The blood analysis method includes: providing a blood sample; mixing a first aliquot of the blood sample with a diluent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample to obtain first volume distribution data; detecting at least two types of optical signals of the second test sample to obtain second volume distribution data; acquiring red blood cell test data of the blood sample; determining, based on the first volume distribution data, the second volume distribution data, and the red blood cell test data, whether the blood sample contains schistocytes; and if the determination result is yes, providing a warning that the blood sample may contain schistocytes.Type: GrantFiled: October 23, 2020Date of Patent: January 16, 2024Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Bo Ye, Wenbo Zheng, Huan Qi, Zhaoyang Li
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Publication number: 20230390153Abstract: The present disclosure provides a hydrogen generation and dispersion device and methods of making and using the same.Type: ApplicationFiled: June 3, 2022Publication date: December 7, 2023Inventors: Zhaoyang Li, Zhaoqin Li
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Patent number: 11781983Abstract: A method, system and storage medium for providing an alarm for indicating that an abnormality is present in a sample analyzer are provided. The method includes: mixing a first aliquot of a blood sample with a diluent agent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample; detecting at least two types of optical signals of the second test sample; acquiring first platelet detection data based on the electrical impedance signals; acquiring second platelet detection data based on the at least two types of optical signals; acquiring an evaluation result based on a difference between the first platelet detection data and the second platelet detection data; determining whether the evaluation result meets a preset condition to provide an alarm.Type: GrantFiled: October 23, 2020Date of Patent: October 10, 2023Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Huan Qi, Wenbo Zheng, Bo Ye, Zhaoyang Li, Yi Ye
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Publication number: 20230181510Abstract: The present invention provides a composition for relief or management of a pain associated with a disorder, e.g., joint or skeletal condition, the composition comprises n effective amount of retinoic acid. Methods of making and using the same are also disclosed.Type: ApplicationFiled: May 21, 2021Publication date: June 15, 2023Inventor: Zhaoyang Li
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Publication number: 20230107555Abstract: A facial expression editing method includes obtaining a to-be-edited image, where the to-be-edited image includes a first face image of a user; obtaining, by using a camera, a first video stream including a second face image of the user; editing the first face image of the user in the to-be-edited image based on the second face image of the user in the first video stream to obtain an edited image, where a facial expression of the user in the edited image is associated with a facial expression of the user in the first video stream.Type: ApplicationFiled: December 2, 2022Publication date: April 6, 2023Inventors: Zhaoyang Li, Xi Zhang, Qinqin He, Yinglu Zhang, Jiping Liao
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Publication number: 20220379208Abstract: A method for generating a special effect for social networking interaction in a virtual environment of a game is performed by an electronic device. The method includes: displaying an object presentation interface of a target battle of the game when loading a virtual scene corresponding to the target battle, the object presentation interface being used for displaying a plurality of virtual objects participating in the target battle; receiving a special effect generating instruction for a first virtual object of the plurality of virtual objects, the special effect generating instruction being used for instructing to generate a special effect based on the first virtual object, and the first virtual object corresponding to a user of the electronic device triggering the special effect; and generating the special effect identifying the first virtual object in the object presentation interface.Type: ApplicationFiled: May 20, 2022Publication date: December 1, 2022Inventors: Yingjie MEI, Zhengguo HAN, Lili HAO, Xianqi JING, Chuan LV, Zhaoyang LI, Ruowei JIANG, Jun ZHANG, Xiaoqiang HONG, Lichao WU, Jiabin LIANG, YI WANG, Yingtong LIU, Hao MENG
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Patent number: 11481027Abstract: The present disclosure provides method and apparatus for processing a document through a plurality of input modalities. A first input may be received, and input modality and type of the first input may be identified, wherein the type includes command and content. A second input may be received, and input modality and type of the second input may be identified. The document may be processed based at least on an identification result for the first input and an identification result for the second input.Type: GrantFiled: December 18, 2018Date of Patent: October 25, 2022Assignee: Microsoft Technology Licensing, LLCInventors: Yifan Wu, Benjamin Yan Sun, Ziwei He, Xiaoli Liu, Mingyang Xie, Zhaoyang Li, Weizhi Li, Qing Teng
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Publication number: 20210365645Abstract: The present invention provides a social safe method of language translation, a device having a software program therefor, and a system comprising a having the software program.Type: ApplicationFiled: September 2, 2020Publication date: November 25, 2021Inventor: Zhaoyang Li
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Patent number: 11125687Abstract: A method for identifying fragmented red blood cells comprising: acquiring side scatter light signals and fluorescence signals of cell particles in a sample liquid; and distinguishing and identifying a fragmented red blood cell population from the cell particles according to the side scatter light signals and the fluorescence signals of the cell particles. The fragmented red blood cell population can be identified from the cell particles by processing and analyzing the side scatter light signals and fluorescence signals of the sample liquid. The present application further provides a device for identifying fragmented red blood cells, a blood cell analyzer and an analysis method. Fragmented red blood cells can be identified according to the fluorescence that characterizes a nucleic acid content in a cell particle and the side scatter light, thus reducing errors in identification and counting.Type: GrantFiled: August 12, 2019Date of Patent: September 21, 2021Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Wenbo Zheng, Bo Ye, Huan Qi, Shan Yu, Xiujuan Li, Zhaoyang Li
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Publication number: 20210102935Abstract: A blood detection method is provided, including: treating a blood sample with a first reagent to obtain a test sample, wherein the first reagent includes a hemolytic agent for lysing red blood cells in the blood sample into fragments having light scattering characteristics significantly different from those of platelets; passing particles in the test sample through a detection area of an optical detection system one by one, to obtain optical information of the test sample; and obtaining optical information of platelets according to at least two types of the optical information of the test sample. In the method, a platelet count is obtained by lysing red blood cells in a blood sample, and white blood cell subpopulations can be also differentiated.Type: ApplicationFiled: October 27, 2020Publication date: April 8, 2021Inventors: Gengwen CHEN, Ziqian ZHANG, Yi YE, Zhaoyang LI
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Publication number: 20210041361Abstract: A method, system and storage medium for providing an alarm for indicating that an abnormality is present in a sample analyzer are provided. The method includes: mixing a first aliquot of a blood sample with a diluent agent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample; detecting at least two types of optical signals of the second test sample; acquiring first platelet detection data based on the electrical impedance signals; acquiring second platelet detection data based on the at least two types of optical signals; acquiring an evaluation result based on a difference between the first platelet detection data and the second platelet detection data; determining whether the evaluation result meets a preset condition to provide an alarm.Type: ApplicationFiled: October 23, 2020Publication date: February 11, 2021Inventors: Huan QI, Wenbo ZHENG, Bo YE, Zhaoyang LI, Yi YE
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Publication number: 20210041343Abstract: A blood analysis method, a blood analysis system, and a storage medium are provided. The blood analysis method includes: providing a blood sample; mixing a first aliquot of the blood sample with a diluent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample to obtain first volume distribution data; detecting at least two types of optical signals of the second test sample to obtain second volume distribution data; acquiring red blood cell test data of the blood sample; determining, based on the first volume distribution data, the second volume distribution data, and the red blood cell test data, whether the blood sample contains schistocytes; and if the determination result is yes, providing a warning that the blood sample may contain schistocytes.Type: ApplicationFiled: October 23, 2020Publication date: February 11, 2021Inventors: Bo YE, Wenbo ZHENG, Huan QI, Zhaoyang LI