Patents by Inventor Zhaoyang Niu

Zhaoyang Niu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
    Patent number: 10100308
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA: Cholesterol Acyltransferase 1, but not Acyl-CoA: Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: October 16, 2018
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20170292128
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA: Cholesterol Acyltransferase 1, but not Acyl-CoA: Cholesterol Acyltransferase 2.
    Type: Application
    Filed: May 28, 2015
    Publication date: October 12, 2017
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
    Patent number: 9388414
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: July 12, 2016
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases
    Patent number: 9388413
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: July 12, 2016
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20150079161
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Application
    Filed: November 21, 2014
    Publication date: March 19, 2015
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Yohei Shibuya, Zhaoyang Niu
  • METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20140308340
    Abstract: The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Application
    Filed: May 29, 2014
    Publication date: October 16, 2014
    Applicant: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Yohei Shibuya, Zhaoyang Niu