Patents by Inventor Zhaozhong Han
Zhaozhong Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240131177Abstract: The present disclosure provides a method to translocate a molecule across cellular membrane by using a transferrin-binding protein. The transferrin-binding protein is capable of specifically binding to transferrin and not disturbing the interaction between transferrin and transferrin receptor.Type: ApplicationFiled: May 31, 2023Publication date: April 25, 2024Applicant: LINNO PHARMACEUTICALS INC.Inventors: Zhaozhong HAN, Hongya PAN, Mengfan PENG
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Publication number: 20240101981Abstract: The present application pertains to a fusion protein, comprising a transferrin-binding protein, and an arylsulfatase A (ARSA) or functionally active fragment thereof, wherein the transferrin-binding protein comprises a peptide, an antibody or an antigen-binding fragment of the antibody capable of binding transferrin. The other aspect of the present application provides the preparing methods and the uses of the fusion protein.Type: ApplicationFiled: October 17, 2023Publication date: March 28, 2024Inventors: Zhaozhong HAN, Hongya PAN, Haiyang LI, Lingyu LI
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Patent number: 10086073Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.Type: GrantFiled: April 8, 2016Date of Patent: October 2, 2018Assignee: WASHINGTON UNIVERSITYInventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
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Publication number: 20160206736Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.Type: ApplicationFiled: April 8, 2016Publication date: July 21, 2016Applicants: Vanderbilt University, Washington UniversityInventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
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Patent number: 9340581Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.Type: GrantFiled: June 18, 2014Date of Patent: May 17, 2016Assignee: WASHINGTON UNIVERSITYInventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
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Publication number: 20140369929Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.Type: ApplicationFiled: June 18, 2014Publication date: December 18, 2014Applicant: VANDERBILT UNIVERSITYInventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
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Patent number: 8765097Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.Type: GrantFiled: February 13, 2013Date of Patent: July 1, 2014Assignees: Washington University, Vanderbilt UniversityInventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
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Publication number: 20130251628Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.Type: ApplicationFiled: February 13, 2013Publication date: September 26, 2013Applicant: Vanderbilt UniversityInventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
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Patent number: 8388932Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.Type: GrantFiled: February 1, 2011Date of Patent: March 5, 2013Assignee: Vanderbilt UniversityInventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
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Publication number: 20110213293Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.Type: ApplicationFiled: February 1, 2011Publication date: September 1, 2011Applicant: VANDERBILT UNIVERSITYInventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
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Patent number: 7906102Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.Type: GrantFiled: July 15, 2005Date of Patent: March 15, 2011Assignee: Vanderbilt UniversityInventors: Dennis E. Hallahan, Shimian Qu, Zhaozhong Han
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Publication number: 20060104898Abstract: A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.Type: ApplicationFiled: July 15, 2005Publication date: May 18, 2006Inventors: Dennis Hallahan, Shimian Qu, Zhaozhong Han