Patents by Inventor Zhehuan CHEN

Zhehuan CHEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation
    Patent number: 11421194
    Abstract: The described invention provides an ex vivo dynamic multiple myeloma cancer niche contained in a pumpless perfusion culture device. The dynamic multiple myeloma cancer niche includes (a) a three-dimensional tissue construct containing a dynamic ex vivo bone marrow niche, which contains a mineralized bone-like tissue containing viable osteoblasts self-organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts; and a microenvironment dynamically perfused by nutrients and dissolved gas molecules; and (b) human myeloma cells seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the bone marrow niche, and the viability of the human myeloma cells is maintained by the multiple myeloma cancer niche.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: August 23, 2022
    Assignees: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY, HACKENSACK MERIDIAN HEALTH CENTER FOR DISCOVERY AND INNOVATION
    Inventors: Woo Lee, Zhehuan Chen, Jenny Zilberberg
  • PUMPLESS PLATFORM FOR HIGH-THROUGHPUT DYNAMIC MULTICELLULAR CULTURE AND CHEMOSENSITIVITY EVALUATION
    Publication number: 20200181551
    Abstract: The described invention provides an ex vivo dynamic multiple myeloma cancer niche contained in a pumpless perfusion culture device. The dynamic multiple myeloma cancer niche includes (a) a three-dimensional tissue construct containing a dynamic ex vivo bone marrow niche, which contains a mineralized bone-like tissue containing viable osteoblasts self-organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts; and a microenvironment dynamically perfused by nutrients and dissolved gas molecules; and (b) human myeloma cells seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the bone marrow niche, and the viability of the human myeloma cells is maintained by the multiple myeloma cancer niche.
    Type: Application
    Filed: December 4, 2019
    Publication date: June 11, 2020
    Applicants: Hackensack Meridian Health Center For Discovery and Innovation, The Trustees of the Stevens Institute of Technology
    Inventors: Woo LEE, Zhehuan CHEN, Jenny ZILBERBERG