Abstract: The present invention discloses a pyrrolidine derivative or its optically active isomer, or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NAD+ expression. The pyrrolidine derivative has pyrrolidine as a parent structure, to which pyridinylurea (or substituted pyridinylurea) is attached by an intermediate aliphatic chain, and a side arylformyl (or heterocyclylformyl) group is attached. This structure is an optimized structure of the NAMPT inhibitor FK866, in which the acrylamido group is replaced by a urea structure, to increases the water solubility of the compound. Moreover, the difficulty in synthesis is reduced accordingly, which is conducive to the subsequent industrial production.

Abstract: The present invention discloses a pyridinylcyanoguanidine derivative or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NAD+ expression. The pyridinylcyanoguanidine derivative has a parent structure including cyanoguanidine attached to piperazine or pyrrolidine by an intermediate aliphatic chain, to which a side arylformyl (or heterocyclylformyl) group and pyridinyl (or substituted pyridinyl) group are attached. This structure comes from the structural optimization of FK866, a high-efficiency NAMPT inhibitor. In the structure, the substituted formyl piperazine and substituted formyl pyrrolidine are the further optimizations on the basis of FK866, which strengthens the interaction with NAMPT.

Abstract: The present invention discloses a pyridinylcyanoguanidine derivative or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NAD expression. The pyridinylcyanoguanidine derivative has a parent structure including cyanoguanidine attached to piperazine or pyrrolidine by an intermediate aliphatic chain, to which a side arylformyl (or heterocyclylformyl) group and pyridinyl (or substituted pyridinyl) group are attached. This structure comes from the structural optimization of FK866, a high-efficiency NAMPT inhibitor. In the structure, the substituted formyl piperazine and substituted formyl pyrrolidine are the further optimizations on the basis of FK866, which strengthens the interaction with NAMPT.

Abstract: The present invention discloses a pyridinylcyanoguanidine derivative or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NAD+ expression. The pyridinylcyanoguanidine derivative has a parent structure including cyanoguanidine attached to piperazine or pyrrolidine by an intermediate aliphatic chain, to which a side arylformyl (or heterocyclylformyl) group and pyridinyl (or substituted pyridinyl) group are attached. This structure comes from the structural optimization of FK866, a high-efficiency NAMPT inhibitor. In the structure, the substituted formyl piperazine and substituted formyl pyrrolidine are the further optimizations on the basis of FK866, which strengthens the interaction with NAMPT.

Abstract: The present invention discloses a pyrrolidine derivative or its optically active isomer, or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NAD+ expression. The pyrrolidine derivative has pyrrolidine as a parent structure, to which pyridinylurea (or substituted pyridinylurea) is attached by an intermediate aliphatic chain, and a side arylformyl (or heterocyclylformyl) group is attached. This structure is an optimized structure of the NAMPT inhibitor FK866, in which the acrylamido group is replaced by a urea structure, to increases the water solubility of the compound. Moreover, the difficulty in synthesis is reduced accordingly, which is conducive to the subsequent industrial production.

Abstract: The present invention discloses a pyridinylcyanoguanidine derivative or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NAD+ expression. The pyridinylcyanoguanidine derivative has a parent structure including cyanoguanidine attached to piperazine or pyrrolidine by an intermediate aliphatic chain, to which a side arylformyl (or heterocyclylformyl) group and pyridinyl (or substituted pyridinyl) group are attached. This structure comes from the structural optimization of FK866, a high-efficiency NAMPT inhibitor. In the structure, the substituted formyl piperazine and substituted formyl pyrrolidine are the further optimizations on the basis of FK866, which strengthens the interaction with NAMPT.

Abstract: A method for producing an aromatic hydrocarbon with an oxygenate as raw material, includes: i) reacting an oxygenate in at least one aromatization reactor to obtain an aromatization reaction product; ii) separating the aromatization reaction product to obtain a gas phase hydrocarbons flow X and a liquid phase hydrocarbons flow Y; iii) after removing gas and/or a part of the oxygenate from the gas phase hydrocarbons flow X, a hydrocarbons flow X1 containing a non-aromatic hydrocarbon is obtained; or after removing gas and/or a part of the oxygenate from the gas phase hydrocarbons flow X, a reaction is conducted in another aromatization reactor and a separation is conducted to obtain a flow X2 containing a non-aromatic hydrocarbon and a flow X3 containing an aromatic hydrocarbon. The flows are further treated.

Abstract: The present invention relates to a catalyst for the conversion of methanol to aromatics and the preparation of the same. The catalyst comprising 85 to 99 parts by weight of a ZSM-5 zeolite, 0.1 to 15 parts by weight of element M1, which is at least one selected from the group consisted of Ag, Zn and Ga, and 0 to 5 parts by weight of element M2, which is at least one selected from the group consisted of Mo, Cu, La, P, Ce and Co, wherein the total specific surface area of the catalyst ranges from 350 to 500 m2/g, and the micropore specific surface area ranges from 200 to 350 m2/g. The catalyst has high total specific surface area, micropore specific surface area and micropore volume. Good catalytic activity can be shown from the results of the reaction of aromatics preparation from methanol using the catalyst provided by the present invention.

Abstract: A method for producing an aromatic hydrocarbon with an oxygenate as raw material, includes: i) reacting an oxygenate in at least one aromatization reactor to obtain an aromatization reaction product; ii) separating the aromatization reaction product to obtain a gas phase hydrocarbons flow X and a liquid phase hydrocarbons flow Y; iii) after removing gas and/or a part of the oxygenate from the gas phase hydrocarbons flow X, a hydrocarbons flow X1 containing a non-aromatic hydrocarbon is obtained; or after removing gas and/or a part of the oxygenate from the gas phase hydrocarbons flow X, a reaction is conducted in another aromatization reactor and a separation is conducted to obtain a flow X2 containing a non-aromatic hydrocarbon and a flow X3 containing an aromatic hydrocarbon. The flows are further treated.

Abstract: The present invention relates to a catalyst for the conversion of methanol to aromatics and the preparation of the same. The catalyst comprising 85 to 99 parts by weight of a ZSM-5 zeolite, 0.1 to 15 parts by weight of element M1, which is at least one selected from the group consisted of Ag, Zn and Ga, and 0 to 5 parts by weight of element M2, which is at least one selected from the group consisted of Mo, Cu, La, P, Ce and Co, wherein the total specific surface area of the catalyst ranges from 350 to 500 m2/g, and the micropore specific surface area ranges from 200 to 350 m2/g. The catalyst has high total specific surface area, micropore specific surface area and micropore volume. Good catalytic activity can be shown from the results of the reaction of aromatics preparation from methanol using the catalyst provided by the present invention.

Abstract: The present invention provides a catalyst comprising metallic Pt and/or Pd supported on a binder-free zeolite for producing light aromatic hydrocarbons and light alkanes from hydrocarbonaceous feedstock, wherein the amount of metallic Pt and/or Pd is of 0.01-0.8 wt %, preferably 0.01-0.5 wt % on the basis of the total weight of the catalyst, and the binder-free zeolite is selected from the group consisting of mordenite, beta zeolite, Y zeolite, ZSM-5, ZSM-11 and composite or cocrystal zeolite thereof. The present invention also provides a process for producing light aromatic hydrocarbons and light alkanes from hydrocarbonaceous feedstock using said catalyst.

Abstract: The present invention provides a catalyst comprising metallic Pt and/or Pd supported on a binder-free zeolite for producing light aromatic hydrocarbons and light alkanes from hydrocarbonaceous feedstock, wherein the amount of metallic Pt and/or Pd is of 0.01-0.8 wt %, preferably 0.01-0.5 wt % on the basis of the total weight of the catalyst, and the binder-free zeolite is selected from the group consisting of mordenite, beta zeolite, Y zeolite, ZSM-5, ZSM-11 and composite or cocrystal zeolite thereof. The present invention also provides a process for producing light aromatic hydrocarbons and light alkanes from hydrocarbonaceous feedstock using said catalyst.

Abstract: The present invention provides a catalyst comprising metallic Pt and/or Pd supported on a binder-free zeolite for producing light aromatic hydrocarbons and light alkanes from hydrocarbonaceous feedstock, wherein the amount of metallic Pt and/or Pd is of 0.01-0.8 wt %, preferably 0.01-0.5 wt % on the basis of the total weight of the catalyst, and the binder-free zeolite is selected from the group consisting of mordenite, beta zeolite, Y zeolite, ZSM-5, ZSM-11 and composite or cocrystal zeolite thereof. The present invention also provides a process for producing light aromatic hydrocarbons and light alkanes from hydrocarbonaceous feedstock using said catalyst.