Patents by Inventor Zhen Chang LIANG
Zhen Chang LIANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11890342Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.Type: GrantFiled: December 22, 2020Date of Patent: February 6, 2024Assignee: International Business Machines CorporationInventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Nathaniel Park, Rudy J. Wojtecki, Yang Chuan, Ashlynn Lee, Zhen Chang Liang, Shaoqiong Liu, Yi Yan Yang
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Patent number: 11766451Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.Type: GrantFiled: December 29, 2020Date of Patent: September 26, 2023Assignee: International Business Machines CorporationInventors: James L Hedrick, Simone Bianco, Mark Kunitomi, Yi Yan Yang, Xin Ding, Chuan Yang, Zhen Chang Liang, Paola Florez de Sessions, Balamurugan Periaswamy
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Patent number: 11572477Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: GrantFiled: November 8, 2019Date of Patent: February 7, 2023Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Institute of Bioengineering and NanotechnologyInventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 11560484Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: GrantFiled: November 8, 2019Date of Patent: January 24, 2023Assignees: International Business Machines Corporation, Institute of Bioengineering and NanotechnologyInventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20220111115Abstract: There is provided a bone cement composition comprising: a powder component comprising at least one acrylic polymer a liquid component comprising a monomer; an antibiotic; and an acid-functionalised polymer, wherein reaction of the powder component and the liquid component results in formation of a bone cement. In a preferred embodiment, the acid-functionalised polymer is selected from polyethylene glycol-polycarbonate (PEG-PAC), polycarbonate-poly(L-lactide) (PAC-PLLA), polycarbonate-poly(D-lactide) (PAC-PDLA), PAC-PLLA/PDLA, copolymers thereof or a combination thereof. There is also provided a bone cement formed from the bone cement composition.Type: ApplicationFiled: July 30, 2019Publication date: April 14, 2022Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPOREInventors: Yi Yan YANG, Zhen Chang LIANG, Chuan YANG, Ee Jen Wilson WANG
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Patent number: 11045552Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.Type: GrantFiled: April 4, 2017Date of Patent: June 29, 2021Assignee: International Business Machines CorporationInventors: Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Nathaniel H. Park, Rudy J. Wojtecki, Yang Chuan, Ashlynn Lee, Zhen Chang Liang, Shaoqiong Liu, Yi Yan Yang
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Publication number: 20210145970Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.Type: ApplicationFiled: December 22, 2020Publication date: May 20, 2021Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Nathaniel PARK, Rudy J. WOJTECKI, Yang CHUAN, Ashlynn LEE, Zhen Chang LIANG, Shaoqiong LIU, Yi Yan YANG
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Publication number: 20210121498Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.Type: ApplicationFiled: December 29, 2020Publication date: April 29, 2021Inventors: James L. Hedrick, Simone Bianco, Mark Kunitomi, Yi Yan Yang, Xin Ding, Chuan Yang, Zhen Chang Liang, Paola Florez de Sessions, Balamurugan Periaswamy
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Patent number: 10953039Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.Type: GrantFiled: September 27, 2018Date of Patent: March 23, 2021Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: James L. Hedrick, Simone Bianco, Mark Kunitomi, Yi Yan Yang, Xin Ding, Chuan Yang, Zhen Chang Liang, Paola Florez de Sessions, Balamurugan Periaswamy
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Patent number: 10752787Abstract: Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.Type: GrantFiled: November 6, 2019Date of Patent: August 25, 2020Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 10745586Abstract: According to one or more embodiments, a method of making an antifouling coating includes forming a polythioaminal polymer by reacting a fluorinated primary amine with an aldehyde to form an intermediate imine, and then reacting the intermediate imine with a dithiol. The method further includes depositing the polythioaminal on a substrate, and increasing a temperature of the polythioaminal deposited on the substrate to crosslink the polythioaminal and increase a contact angle of the substrate with crosslinked polythioaminal.Type: GrantFiled: August 8, 2017Date of Patent: August 18, 2020Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGYInventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 10696849Abstract: Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.Type: GrantFiled: August 8, 2017Date of Patent: June 30, 2020Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGYInventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20200101105Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.Type: ApplicationFiled: September 27, 2018Publication date: April 2, 2020Inventors: James L. Hedrick, Simone Bianco, Mark Kunitomi, Yi Yan Yang, Xin Ding, Chuan Yang, Zhen Chang Liang, Paola Florez de Sessions, Balamurugan Periaswamy
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Publication number: 20200071542Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20200071543Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20200071541Abstract: Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.Type: ApplicationFiled: November 6, 2019Publication date: March 5, 2020Inventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 10563069Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: GrantFiled: March 30, 2017Date of Patent: February 18, 2020Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Institute of Bioengineering and NanotechnologyInventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20190048226Abstract: According to one or more embodiments, a method of making an antifouling coating includes forming a polythioaminal polymer by reacting a fluorinated primary amine with an aldehyde to form an intermediate imine, and then reacting the intermediate imine with a dithiol. The method further includes depositing the polythioaminal on a substrate, and increasing a temperature of the polythioaminal deposited on the substrate to crosslink the polythioaminal and increase a contact angle of the substrate with crosslinked polythioaminal.Type: ApplicationFiled: August 8, 2017Publication date: February 14, 2019Inventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20190048208Abstract: Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.Type: ApplicationFiled: August 8, 2017Publication date: February 14, 2019Inventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20180280515Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.Type: ApplicationFiled: April 4, 2017Publication date: October 4, 2018Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Nathaniel H. PARK, Rudy J. WOJTECKI, Yang CHUAN, Ashlynn LEE, Zhen Chang LIANG, Shaoqiong LIU, Yi Yan YANG