Patents by Inventor Zhen CHANG
Zhen CHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10953039Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.Type: GrantFiled: September 27, 2018Date of Patent: March 23, 2021Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: James L. Hedrick, Simone Bianco, Mark Kunitomi, Yi Yan Yang, Xin Ding, Chuan Yang, Zhen Chang Liang, Paola Florez de Sessions, Balamurugan Periaswamy
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Patent number: 10828390Abstract: The present invention relates to the technical field of reconstructive plastic surgery and cosmetology, and particularly to a biomimetic chitosan filler for preventing capsular contracture and preparation method thereof. The biomimetic chitosan filler for preventing capsular contracture includes chitosan gel, cross-linked sodium hyaluronate, surfactant, isoosmotic regulator, autologous adipose-derived stem cells, pH adjusting agent and water. The amount of the pH adjusting agent is to adjust a pH value of the chitosan filler to be within a range of 6.5-7.5. The chitosan filler prepared according to the present invention can reduce the inflammation caused by post-operative silica gel exudation, and prevent the occurrence and development of capsular contracture.Type: GrantFiled: December 25, 2017Date of Patent: November 10, 2020Assignee: SHANGHAI HAOHAI BIOLOGICAL TECHNOLOGY CO., LTD.Inventors: Kun Zhang, Wanhua Chen, Bingqian Bu, Jianying Wu, Jundong Zhang, Zhen Chang, Peng Du
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Patent number: 10752787Abstract: Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.Type: GrantFiled: November 6, 2019Date of Patent: August 25, 2020Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 10745586Abstract: According to one or more embodiments, a method of making an antifouling coating includes forming a polythioaminal polymer by reacting a fluorinated primary amine with an aldehyde to form an intermediate imine, and then reacting the intermediate imine with a dithiol. The method further includes depositing the polythioaminal on a substrate, and increasing a temperature of the polythioaminal deposited on the substrate to crosslink the polythioaminal and increase a contact angle of the substrate with crosslinked polythioaminal.Type: GrantFiled: August 8, 2017Date of Patent: August 18, 2020Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGYInventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20200230287Abstract: The present invention relates to the technical field of reconstructive plastic surgery and cosmetology, and particularly to a biomimetic chitosan filler for preventing capsular contracture and preparation method thereof. The biomimetic chitosan filler for preventing capsular contracture includes chitosan gel, cross-linked sodium hyaluronate, surfactant, isoosmotic regulator, autologous adipose-derived stem cells, pH adjusting agent and water. The amount of the pH adjusting agent is to adjust a pH value of the chitosan filler to be within a range of 6.5-7.5. The chitosan filler prepared according to the present invention can reduce the inflammation caused by post-operative silica gel exudation, and prevent the occurrence and development of capsular contracture.Type: ApplicationFiled: December 25, 2017Publication date: July 23, 2020Applicant: Shanghai Haohai Biological Technology Co.,LtdInventors: Kun ZHANG, Wanhua CHEN, Bingqian BU, Jianying WU, Jundong ZHANG, Zhen CHANG, Peng DU
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Patent number: 10696849Abstract: Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.Type: GrantFiled: August 8, 2017Date of Patent: June 30, 2020Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGYInventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20200176862Abstract: An antenna and antenna module with a structure increasing radio wave coverage but reducing cross interference between modules includes a circuit board in the shape of an octagon and four antenna modules. The circuit board thus includes eight side surfaces, and the four antenna modules are respectively disposed on four non-adjacent side surfaces of the octagon. Each antenna module is electrically connected to the side surface by a feed portion. A wireless communication device using the antenna structure is also disclosed.Type: ApplicationFiled: October 28, 2019Publication date: June 4, 2020Inventors: KUO-CHENG CHEN, JIAN-WEI CHANG, ZHEN-CHANG TANG, HSIAO-HUNG LIU, HSI-HSING HSU, JIA CHEN, YI-KUO CHEN
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Publication number: 20200136235Abstract: An antenna structure applied in a wireless communication device includes a metal frame. The wireless communication device includes at least one electronic component. The metal frame includes a substrate. The substrate includes an antenna. The antenna includes a feed portion and a gap. The feed portion spans the gap. The metal frame is spaced from the electronic component. A clearance is formed between the metal frame and the electronic component.Type: ApplicationFiled: October 16, 2019Publication date: April 30, 2020Inventors: JIA CHEN, KUO-CHENG CHEN, JIAN-WEI CHANG, ZHEN-CHANG TANG, YI-LING JIANG, WEI-YU YE, BO PENG, CHUN-SHENG WU
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Publication number: 20200106160Abstract: An antenna structure includes a metal frame, at least one feed source, and a feed portion. The metal frame includes at least one radiating portion and at least one slot. The at least one slot is disposed in the at least one radiating portion or adjacent to the at least one radiating portion. The at least one feed source and the at least one radiating portion form a first antenna. The feed portion and the at least one slot form a second antenna. The at least one feed source supplies an electric current for the first antenna, thereby exciting a first working mode and generating a radiation signal in a first frequency band. The feed portion spans the at least one slot to supply the electric current for the second antenna, thereby exciting a second working mode and generating a radiation signal in a second frequency band.Type: ApplicationFiled: September 16, 2019Publication date: April 2, 2020Inventors: JIA CHEN, KUO-CHENG CHEN, JIAN-WEI CHANG, ZHEN-CHANG TANG, BO PENG, WEI-YU YE, CHUN-SHENG WU, YI-LING JIANG
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Publication number: 20200101105Abstract: Techniques regarding treating one or more microbe infections with combination therapy are provided. For example, one or more embodiments described herein can comprise a method, which can comprise enhancing an antimicrobial activity of an antibiotic by a combination therapy. The combination therapy can comprise the antibiotic and a polycarbonate polymer functionalized with a guanidinium functional group.Type: ApplicationFiled: September 27, 2018Publication date: April 2, 2020Inventors: James L. Hedrick, Simone Bianco, Mark Kunitomi, Yi Yan Yang, Xin Ding, Chuan Yang, Zhen Chang Liang, Paola Florez de Sessions, Balamurugan Periaswamy
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Publication number: 20200091589Abstract: An antenna structure includes a metal frame. The metal frame includes a first surface, a second surface, and a third surface. The third surface is located between the first surface and the second surface. The metal frame includes at least one antenna. The at least one antenna includes a first gap, a second gap, and a feed portion. The first gap is disposed between the first surface and the second surface. The second gap is disposed in the third surface. The feed portion is mounted on the first surface and spans the first gap. When the feed portion supplies an electric current, the electric current is coupled to the first gap and the second gap.Type: ApplicationFiled: September 12, 2019Publication date: March 19, 2020Inventors: JIA CHEN, KUO-CHENG CHEN, JIAN-WEI CHANG, ZHEN-CHANG TANG, BO PENG, WEI-YU YE, CHUN-SHENG WU
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Publication number: 20200071543Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20200071541Abstract: Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.Type: ApplicationFiled: November 6, 2019Publication date: March 5, 2020Inventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20200071542Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 10563069Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: GrantFiled: March 30, 2017Date of Patent: February 18, 2020Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, Institute of Bioengineering and NanotechnologyInventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20190048226Abstract: According to one or more embodiments, a method of making an antifouling coating includes forming a polythioaminal polymer by reacting a fluorinated primary amine with an aldehyde to form an intermediate imine, and then reacting the intermediate imine with a dithiol. The method further includes depositing the polythioaminal on a substrate, and increasing a temperature of the polythioaminal deposited on the substrate to crosslink the polythioaminal and increase a contact angle of the substrate with crosslinked polythioaminal.Type: ApplicationFiled: August 8, 2017Publication date: February 14, 2019Inventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20190048208Abstract: Embodiments are directed to a method of making an antifouling and bactericidal coating with tailorable surface topology. The method includes depositing a layer of branched polyethyleneimine (BPEI) and diamino-functionalized poly(propylene oxide) (PPO) in a mixture of water and organic solvent on a substrate to form a layer of BPEI/PPO. The method includes depositing a layer of glyoxal in a water-containing solution on the layer of BPEI/PPO. The method further includes curing the layer of BPEI/PPO and layer of glyoxal to form a homogenous, glyoxal crosslinked BPEI/PPO coating, where the curing induces local precipitation and alteration of the glyoxal crosslinked BPEI/PPO coating to provide a textured surface.Type: ApplicationFiled: August 8, 2017Publication date: February 14, 2019Inventors: Amos Cahan, Xin Ding, Mareva B. Fevre, James L. Hedrick, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Publication number: 20180280515Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.Type: ApplicationFiled: April 4, 2017Publication date: October 4, 2018Inventors: Dylan J. BODAY, Jeannette M. GARCIA, James L. HEDRICK, Nathaniel H. PARK, Rudy J. WOJTECKI, Yang CHUAN, Ashlynn LEE, Zhen Chang LIANG, Shaoqiong LIU, Yi Yan YANG
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Publication number: 20180282556Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.Type: ApplicationFiled: March 30, 2017Publication date: October 4, 2018Inventors: Amos Cahan, Hariklia Deligianni, Xin Ding, Mareva B. Fevre, James L. Hedrick, Pei-Yun S. Hsueh, Zhen Chang Liang, Nathaniel H. Park, Theodore G. van Kessel, Rudy J. Wojtecki, Yi Yan Yang
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Patent number: 7878491Abstract: An exemplary clamp includes a holder, a moving unit, a fixing arm, and a driving unit. The moving unit includes a push block, a connecting member, and a guiding member. The guiding member is fixed on the holder. The connecting member connects the push block and the guiding member. The push block includes a slanted side surface. The push block is guided to move by the guiding member. The slanted side surface of the push block interacts with the connecting member. The fixing arm is fixed to the connecting member. The driving unit is connected to the push block. The driving unit is capable of moving the push block of the moving unit.Type: GrantFiled: July 21, 2008Date of Patent: February 1, 2011Assignees: Hong Fu Jin Precision Industry (ShenZhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.Inventors: Hua Li, Xi-Song Shuai, Zhen-Chang Tian, Zhuang Xiong, Dong Li