Patents by Inventor Zhen-Dan Shi
Zhen-Dan Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240010601Abstract: The disclosure provides methods of synthesizing very long chain fatty acids, including deuterated very long chain fatty acids. The fatty acids can by polyunsaturated fatty acids. The methods include the step of reacting a protected leaving group (L)-substituted saturated aliphatic group with a halo-substituted unsaturated aliphatic group to form a protected aliphatic group. The protected aliphatic group is deprotected to form an alcohol. The alcohol is then oxidized, thereby forming a very long chain fatty acid.Type: ApplicationFiled: August 31, 2021Publication date: January 11, 2024Inventors: Rolf SWENSON, Alan REMALEY, Zhen-Dan SHI, Zhi-hong YANG
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Publication number: 20220273829Abstract: Disclosed herein are compounds having a structure according to Formula I and optionally Formula IV. The compounds may be radiolabeled compounds useful for diagnosis and/or imaging fungal infections. In such embodiments, at least one substituent is a radionuclide, such as 18F. Also disclosed are precursor compounds according to Formula I and/or IV that are useful for making the radiolabeled compounds. In such embodiments, the precursor compound comprises at least one leaving group suitable for introducing a radionuclide, such as 18F, at a desired position. Also disclosed are methods for making and using the compounds, including embodiments of a method for imaging and/or diagnosing a fungal infection in a subject.Type: ApplicationFiled: July 31, 2020Publication date: September 1, 2022Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human ServicInventors: Dima A. Hammoud, Rolf Eric Swenson, Xiang Zhang, Swati Shah, Peter R. Williamson, Zhen-Dan Shi
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Patent number: 8754081Abstract: Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.Type: GrantFiled: March 31, 2009Date of Patent: June 17, 2014Assignee: The United States of America as represented by the Secretary, Departmnet of Health and Human ServicesInventors: Donald P. Bottaro, Megan Peach, Marc Nicklaus, Terrence Burke, Jr., Gagani Athauda, Sarah Choyke, Alessio Giubellino, Nelly Tan, Zhen-Dan Shi
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Publication number: 20110190295Abstract: Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.Type: ApplicationFiled: March 31, 2009Publication date: August 4, 2011Applicant: The Govt of the U.S.A., as rep.by the Sec.Dept of Hlth. and Human Svcs., Natl Institutes of HealthInventors: Donald P. Bottaro, Megan Peach, Marc Nicklaus, Terrence Burke, JR., Gagani Athauda, Sarah Choyke, Alessio Giubellino, Nelly Tan, Zhen-Dan Shi
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Patent number: 7767645Abstract: Disclosed are compounds represented by the formula: or a pharmaceutically acceptable salt or isomer thereof, wherein R1-R6 are as defined in the specification. These compounds are targeted for use as inhibitors of SH2 domain binding with a phosphoprotein, and are contemplated for use in a number of diseases including cancer. Also disclosed are pharmaceutical compositions comprising a compound of the invention and a pharmaceutically acceptable carrier.Type: GrantFiled: October 31, 2007Date of Patent: August 3, 2010Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Terrence R. Burke, Jr., Zhen-Dan Shi, Sang-Uk Kang
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Patent number: 7425537Abstract: Disclosed are compounds for SH2 domain binding inhibition, for example, a compound of formula (I), wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is hydrogen, azido, amino, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, or alkylcarbonylamino, wherein the alkyl portion of R3 may be optionally substituted with a substituent selected from the group consisting of halo, hydroxy, carboxyl, amino, aminoalkyl, alkyl, alkoxy, and keto; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a salt thereof. The conformationally compounds provide enhanced binding affinity with SH2 domain protein. Also disclosed are a pharmaceutical compositions and a method for inhibiting an SH2 domain from binding with a phosphoprotein.Type: GrantFiled: June 26, 2003Date of Patent: September 16, 2008Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Terrence R Burke, Jr., Chang-Qing Wei, Zhen-Dan Shi, Yang Gao
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Publication number: 20080139456Abstract: Disclosed are compounds for inhibiting the binding of an SH2 domain-containing protein, for example, a compound of formula (I): FORMULA (I) wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is, for example, hydrogen, azido, amino, oxalylamino, carboxy alkyl, alkoxycarbonyl alkyl, aminocarbonyl alkyl, or alkyl carbonylamino; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a pharmaceutically acceptable salt, stereoisomer, solvate, or hydrate thereof. Also disclosed are pharmaceutical compositions and methods of use of such compounds.Type: ApplicationFiled: September 30, 2005Publication date: June 12, 2008Inventors: Terrence R. Burke, Zhen-Dan Shi, Shinya Oishi, Fa Liu
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Publication number: 20080132469Abstract: Disclosed are compounds represented by the formula: or a pharmaceutically acceptable salt or isomer thereof, wherein R1-R6 are as defined in the specification. These compounds are targeted for use as inhibitors of SH2 domain binding with a phosphoprotein, and are contemplated for use in a number of diseases including cancer. Also disclosed are pharmaceutical compositions comprising a compound of the invention and a pharmaceutically acceptable carrier.Type: ApplicationFiled: October 31, 2007Publication date: June 5, 2008Applicant: GOVERNMENT OF THE UNITED STATES, REPRESENTED BY THE SECRETARY, DEPARTMENTInventors: Terrence R. BURKE, Zhen-Dan SHI, Sang-Uk KANG
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Publication number: 20060167222Abstract: Disclosed are compounds for SH2 domain binding inhibition, for example, a compound of formula (I), wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is hydrogen, azido, amino, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, or alkylcarbonylamino, wherein the alkyl portion of R3 may be optionally substituted with a substituent selected from the group consisting of halo, hydroxy, carboxyl, amino, aminoalkyl, alkyl, alkoxy, and keto; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a salt thereof. The conformationally compounds provide enhanced binding affinity with SH2 domain protein. Also disclosed are a pharmaceutical compositions and a method for inhibiting an SH2 domain from binding with a phosphoprotein.Type: ApplicationFiled: June 26, 2003Publication date: July 27, 2006Inventors: Terrence Burke, Chang-Qing Wei, Zhen-DaN Shi, Yang Gao
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Publication number: 20050119163Abstract: Disclosed are compounds represented by the formula: or a pharmaceutically acceptable salt or isomer thereof, wherein R1-R6 are as defined in the specification. These compounds are targeted for use as inhibitors of SH2 domain binding with a phosphoprotein, and are contemplated for use in a number of diseases including cancer. Also disclosed are pharmaceutical compositions comprising a compound of the invention and a pharmaceutically acceptable carrier.Type: ApplicationFiled: September 17, 2004Publication date: June 2, 2005Applicants: The Government of the United States of America, as Represented by the Secretary,, Department of Health and Human ServicesInventors: Terrence Burke, Zhen-Dan Shi, Sang-Uk Kang