Abstract: Provided are a fused tricyclic cyclin-dependent kinase inhibitor, and a preparation method therefor and a pharmaceutical use thereof. In particular, the structure of the fused tricyclic cyclin-dependent kinase inhibitor is shown in formula I, wherein substituents are defined in the description. The fused tricyclic cyclin-dependent kinase inhibitor is used for preventing and/or treating cyclin-dependent kinase related diseases, in particular cancers.

Abstract: Disclosed is a hollow sulfide microsphere with enriched sulfur vacancies, which is prepared by a method comprising the steps of: dissolving cobalt nitrate and nickel nitrate in a mixed solution of N, N-dimethylformamide and acetone with an equal volume; then adding a chelating agent thereto, subjecting a resulting mixture to a solvothermal reaction to obtain a coordination polymer microsphere; dissolving the coordination polymer microsphere and a sulfurization agent in an organic solvent, and reacting to obtain a hollow sulfide microsphere; and subjecting the hollow sulfide microsphere to reduction treatment with sodium borohydride, centrifuging, washing and drying to obtain the hollow sulfide microsphere with enriched sulfur vacancies having a particle size of 1-2.5 ?m, a shell thickness of 15-30 nm and a specific capacity of the material of 763.4 C g?1 (current density is 1 A g?1).

Abstract: The present invention relates to a class of TrkA inhibitors and an application thereof in the preparation of a drug for the treatment of diseases associated with TrkA. The present invention specifically discloses compounds represented by formula (I) and formula (II), tautomer thereof or pharmaceutically acceptable salts thereof.

Abstract: The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.

Abstract: Provided is a method for preventing the accumulation of cylinder oil at scavenging ports of low-speed marine engines. An oil passage is provided on a cylinder wall inside a cylinder. The oil passage includes multiple oil storage grooves processed in a circumferential direction of the cylinder wall. The oil passage is formed by obliquely extending from the inner side of the cylinder wall to the outside of the cylinder in a radial direction of the cylinder. The scavenging ports are uniformly distributed in a circumferential direction of the cylinder wall, and each of the oil storage grooves is correspondingly processed at an upper portion of the scavenging port upper edge of the scavenging port. Each of the oil storage grooves has a shape matching the curved surface of the scavenging port upper edge.

Abstract: A fluid outputting massager includes a fluid storage assembly and a tooth plate connected to the liquid storage assembly to define at least one liquid storage cavity. The tooth plate is arranged with a plurality of fluid outputting teeth, which are soft. A tip portion of each fluid outputting tooth has at least one fluid outputting hole communicating with the fluid storage cavity. The fluid outputting tooth can output fluid from the fluid outputting hole when being pressed.

Abstract: Disclosed are a thieno[2,3-c]pyridazin-4(1H)-one derivative as an ACC1 or ACC2 inhibitor and an application thereof in preparing a drug as an ACC1 or ACC2 inhibitor. In particular, disclosed is a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses an electromagnetic shielding package structure and a package method thereof. The package method for the electromagnetic shielding package structure includes: providing a base plate of a copper raw material, and forming a transition layer after two photoresist film operations, wherein the transition layer includes conductive connecting ribs connecting functional pins to an outer side wall; mounting a chip. performing first encapsulating, and etching off the conductive connecting ribs connecting the functional pins to the outer side wall; performing secondary encapsulating on an etched part; and after forming a singulated body by cutting, blocking the connection between the functional pins and the outer side wall by a plastic package material, and only reserving grounding pins to be connected to the outer side wall through the conductive connecting ribs.

Abstract: The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.

Abstract: Provided is a method for preventing the accumulation of cylinder oil at scavenging ports of low-speed marine engines. An oil passage is provided on a cylinder wall inside a cylinder. The oil passage includes multiple oil storage grooves processed in a circumferential direction of the cylinder wall. The oil passage is formed by obliquely extending from the inner side of the cylinder wall to the outside of the cylinder in a radial direction of the cylinder. The scavenging ports are uniformly distributed in a circumferential direction of the cylinder wall, and each of the oil storage grooves is correspondingly processed at an upper portion of the scavenging port upper edge of the scavenging port. Each of the oil storage grooves has a shape matching the curved surface of the scavenging port upper edge.

Abstract: The present invention relates to a class of thienodiazepine derivatives and an application thereof in the preparation of a drug for the treatment of diseases associated with bromodomain and extra-terminal (BET) Bromodomain inhibitors. Specifically, the present invention relates to compounds represented by formulas (I) and (II), as well as pharmaceutically acceptable salts thereof.

Abstract: A series of pyrazolopyrimidine derivatives can be used in preparing a medicament for treating a disease related to PI3K. For example, a compound of formula (I), a tautomer thereof or a pharmaceutically acceptable composition thereof are effective in treating a disease related to P13K.

Abstract: Disclosed is to a thiadiazole derivative and the uses thereof in preparing a drug for treating GLS1-associated diseases. Specifically disclosed is a derivative compound of formula (I), a tautomer thereof or a pharmaceutically acceptable composition thereof.

Abstract: A series of pyrazolopymidine derivatives, and use thereof in the preparation of a medicament for treating disease associated with FGFR and c-Met. The pyrazolopymidine derivative is a compound represented by formula (I), a tautomer, or a pharmaceutically acceptable salt thereof.