Abstract: Aspects of the disclosure provide a semiconductor device. The semiconductor device includes a memory stack of gate layers and insulating layers. The gate layers and the insulating layers are stacked alternatingly and are formed into stair steps in a staircase region. The semiconductor device includes a first landing pad on a first gate layer of a first stair step. The first gate layer is a top gate layer of the first stair step. The semiconductor device further includes a first sidewall isolation structure on a riser sidewall of a second gate layer of a second stair step. The second gate layer is a top gate layer of the second stair step and is stacked on the first gate layer in the memory stack. The first sidewall isolation structure isolates the second gate layer from the first landing pad.

Abstract: Embodiments of three-dimensional (3D) memory devices are disclosed. In an example, a 3D memory device includes a semiconductor layer, a memory stack over the semiconductor layer, first channel structures each extending vertically through the memory stack in an edge region, and an isolation structure. The memory stack includes a plurality of interleaved conductive layers and dielectric layers. At least one of conductive layers toward the semiconductor layer is a source select gate line (SSG). The isolation structure extends vertically through the SSG and into the semiconductor layer. The memory stack includes a core array region, a staircase region, and the edge region being laterally between the core array region and the staircase region. At least one of the first channel structures extends through the isolation structure and is separated from the SSG through the isolation structure.

Abstract: A pharmaceutical composition comprising azilsartan medoxomil potassium and a calcium channel blocker, a method for preparing same, and use thereof are provided. Azilsartan medoxomil potassium and the calcium channel blocker are formulated into a compound formulation, thus improving the blood pressure lowering efficacy, improving safety and tolerability, and reducing adverse effects. Azilsartan medoxomil potassium can ameliorate peripheral edema caused by amlodipine by means of expanding peripheral venous vessels, while amlodipine can ameliorate adverse effects such as vasogenic edema, dry cough, and the like caused by azilsartan medoxomil potassium.

Abstract: A nebivolol and amlodipine composition, which comprises nebivolol and amlodipine, is provided. The nebivolol comprises one or more of nebivolol, a pharmaceutically acceptable salt thereof, and a solvate thereof. The amlodipine comprises one or more of amlodipine, a pharmaceutically acceptable salt thereof, and a solvate thereof. A nebivolol and amlodipine compound preparation is beneficial for improving the blood pressure reduction effect, improving the safety and tolerance, and reducing side effects. Compared with single medicines of nebivolol and amlodipine, the combination of nebivolol and amlodipine has the advantages of: reducing the number of medicines taken, which improves patient compliance; facilitating the medicine-taking compliance of old people or people with dysphagia; maintaining a stable plasma concentration in vivo, maintaining stable blood pressure for a hypertension patient over the long run, and reducing the side effects of the single medicine.

Abstract: Methods, devices, systems, and techniques for managing structure leakage in semiconductor devices are provided. In one aspect, a semiconductor device includes memory cells. Each memory cell includes a transistor having a semiconductor body and a gate structure. Gate structures of transistors of two adjacent memory cells extend along a first direction in a first trench structure. The semiconductor body includes first and second terminals at opposite ends of the semiconductor body along the first direction. The semiconductor device further includes a diffusion region including a first diffusion portion, a second diffusion portion, and a middle portion along the first direction. The diffusion region surrounds a first end of the first trench structure. A first area of the first trench structure surrounded by the first diffusion portion is greater than a second area of the first trench structure surrounded by the middle diffusion portion and the second diffusion portion.

Abstract: Systems and methods are directed to redacting and reinstating personal identifying information (PII) from text data. A PII management system accesses an input text and identifies, using one or more redaction components, PII mentions in the input text to be redacted. A placeholder manager of the PII management system replaces each unique PII string of a final set of PII mentions with a non-PII string to generate redacted text, whereby the non-PII string is generated by the placeholder manager. The placeholder manager also generates a mapping dictionary that maps each unique PII string to the non-PII string that replaces it. The mapping dictionary is used to reinsert one or more unique PII strings after processing of the redacted text. The redacted text is then transmitted to a downstream component for the processing.

Abstract: A method of fabricating a three-dimensional memory includes forming a laminated structure including stacked dummy gate layers and interlayer insulation layers on one side of a substrate. The respective adjacent dummy gate layers and interlayer insulation layers form staircase stairs. At least a part of the interlayer insulation layer of each of the staircase stairs is exposed. The method also includes forming a buffer layer covering the staircase stairs. The method further includes removing a part of the buffer layer covering the sidewalls of the staircase stairs to form spacing grooves. The method further includes forming a dielectric layer that fills the spacing grooves and covers the staircase stairs. The method further includes forming a contact hole penetrating through the dielectric layer and the buffer layer and extending to the dummy gate layer farthest from the substrate.

Abstract: The present application provides an on-off valve and a liquid supply path system. The on-off valve includes: a valve housing defining a receiving cavity, the valve housing having a liquid inlet passage and a liquid outlet passage, wherein both the liquid inlet passage and the liquid outlet passage communicate with the receiving cavity; a sealing member provided in the receiving cavity, wherein a buffer chamber is formed between the sealing member and the liquid outlet passage; a buffer member provided between the liquid inlet passage and the sealing member; wherein in an initial state, the buffer member abuts against the sealing member to block communication between the liquid inlet passage and the liquid outlet passage; under action of negative pressure in the buffer chamber, a gap is formed between the sealing member and the buffer member, and the liquid inlet passage and the liquid outlet passage communicate through the gap.

Abstract: A lurasidone hydrochloride oral soluble film composition, a preparation method therefor and a use thereof are provided. The lurasidone hydrochloride oral soluble film composition contains an active drug, a film-forming material, a plasticizer and a flavoring agent. The active drug is (3aR,4S,7R,7aS)-2-((1R,2R)-2-[4-(1.2-benzisothiazole 3-yl)piperazine-1-methyl]cyclohexylmethyl)hexahydro-4.7-methylene-2H-isoindole-1,3-dione hydrochloride, as shown in Formula I.

Abstract: This application discloses a comprehensive treatment method for salinized soil in semi-arid region, comprises: stripping and collecting the topsoil; spreading sandy soil and/or loess soil as a imported soil layer; spreading an anti-seepage layer, a salt barrier layer and a membrane layer successively on the imported soil layer; mixing clay into the topsoil to obtain mixed soil; blending saline-alkali land conditioner with the mixed soil to obtain planted soil; spreading the planted soil on the membrane layer to obtain a planting layer. The method combines physical, hydraulic, chemical and biological remediation methods to comprehensively manage saline-alkali soil in semi-arid areas. It consumes less water resources, has a shorter treatment cycle, shows quick results, is conducive to plant growth, and can effectively inhibit the return of salt.

Abstract: A method includes forming a stack of alternating insulating layers and sacrificial layers over a substrate; forming a trench through the stack to uncover the substrate to expose lateral sides of the insulating layers and the sacrificial layers, the trench extending from a core area to a stair step area of the stack; forming a liner to cover the exposed lateral sides; removing the liner in the trenches within a first area of the core area and the stair step area to expose the lateral sides of the sacrificial layers of the stack within the first area; removing the sacrificial layers within the first area; removing the liner in the trenches within a second area of the core area and the stair step area to expose the lateral sides of the sacrificial layers of the stack within the second area; and removing the sacrificial layers within the second area.

Abstract: A brivaracetam pharmaceutical composition contains an active pharmaceutical ingredient, a matrix forming agent, and a swelling agent. It has a sustained release effect and has a more flat release curve compared with a common gel skeleton sustained-release preparation, and thus achieves the purposes of reducing the release rate of the medicament, controlling the in vivo effective dosage of the medicament, stabilizing the blood concentration, reducing toxic and side effects and reducing the times of daily administration.

Abstract: The present invention relates to a seepage erosion test system designed to evaluate soil erosion under controlled conditions. The system includes an acrylic rectangular pipe featuring a circular opening at its lower end. Attached to this is a soil sample pushing sub-device that encompasses a cylindrical sample tube, a piston, and four pore pressure gauges. The piston, which moves vertically within the tube. Additionally, the system incorporates a graduated cylinder pressurizing sub-device consisting of a graduated cylinder for water, a push plate, and a second pushing device for hydraulic pressurization. Water flow is regulated through a hose connected at one end to the piston and equipped with a valve for control. An air release valve and an air pressure sensor are also included for monitoring pressurization. The setup is completed with a three-way valve connected to the pipe, facilitating precise control of water flow and pressure during testing.

Abstract: An antifibrotic composition includes 3-(4-(dihexylamino)-3-fluorophenyl)-2,6-dimethylpyrimidin-4(3H)-one or a pharmaceutically acceptable salt thereof and an antioxidant. The composition has the advantages of easy storage, stable and controllable quality, high bioavailability, etc. Moreover, the composition has a high efficacy and a high safety, and the compliance of a patient taking the composition is good.

Abstract: A pemetrexed disodium liquid composition, a preparation method therefor and use thereof are provided. The pemetrexed disodium liquid composition contains an active pharmaceutical ingredient and a stabilizer. The active pharmaceutical ingredient is one or more of pemetrexed disodium, and a pharmaceutically acceptable complex, a salt, a solvate and a hydrate of pemetrexed disodium. The stabilizer is one or more of an organic solvent, a pH regulator and an antioxidant.

Abstract: A method of monitoring a particle size distribution (PSD) is provided. At least a partially coherent pupil-engineered beam may be produced. A plurality of particles having a particle size distribution (PSD) may be illuminated by the pupil-engineered beam to produce scattered light. The scattered light may be captured by a pixelated photoelectric detector, thereby creating a raw speckled image. An intensity correlation of the raw speckled image may be computed. The intensity correlation may be provided to an inverse module. The inverse module may be configured to determine the PSD based on the intensity correlation. The PSD may be obtained from the inverse module.

Abstract: A method of monitoring a particle size distribution (PSD) is provided. A plurality of particles having a particle size distribution (PSD) may be illuminated by an at least partially coherent beam to produce scattered light. The scattered light may be captured by a pixelated photoelectric detector, thereby creating an ensemble of raw speckled images. Based on the ensemble of the raw speckled images. an ensemble-averaged intensity correlation may be computed. The ensemble-averaged intensity correlation may be provided to an inverse module. The inverse module may be configured to determine the PSD based on the ensemble-averaged intensity correlation. The particle size distribution may be obtained from the inverse module.

Abstract: Disclosed are 1-hydroxy-2-naphthoate or bis-hydroxynaphthenate of cariprazine, a new solid form thereof, a pharmaceutical composition thereof, and a preparation method therefor and the use thereof. The cariprazine salt and the solid form thereof, especially 1-hydroxy-2-naphthoate of cariprazine in an insoluble salt of cariprazine has the advantages of a long-acting sustained-release preparation, can be developed into a suspension injection, can also solve the problems of the risk of the dissociation or the lack of sustained release effect of existing salt types such as cariprazine hydrochloride, can achieve the effect of long-acting administration, and greatly improves the compliance of a patient and the bioavailability and medication safety of a drug.

Abstract: Aspects of the disclosure provide methods for fabricating semiconductor devices. In some examples, a method for fabricating a semiconductor device includes forming a stack of layers having a first region and a second region. The stack of layers includes at least a first layer. The method then forms a hard mask layer on the stack of layers in the first region. Then, the method includes patterning the stack of layers in the second region of the semiconductor device. The patterning of the stack of layers in the second region removes a portion of the stack of layers in the second region, and exposes a side of the stack of layers. The method further includes covering at least the side of the stack of layers with a second layer that has a lower remove rate than the first layer, and then the method includes removing the hard mask layer.