Abstract: Described are 5?-cyclo-phosphonate modified nucleotides, and oligonucleotides, such as interference (RNAi) agents, containing 5?-cyclo-phosphonate modified nucleotides. The RNAi agents having either double-stranded or single-stranded oligonucleotides described herein comprising 5?cyclo-phosphonate modified nucleotides are useful in modulating gene expression as well as therapeutic, diagnostic, target validation, and genomic discovery applications. The RNAi agents and single-stranded antisense oligonucleotides comprising 5?-cyclo-phosphonate modified nucleotides are useful in the treatment of diseases or conditions that respond to inhibition of gene expression or activity in a cell, tissue, or organism.

Abstract: A liner hanger includes an outer tube assembly, an inner tube and a torque transmitting assembly. The torque transmitting assembly has a torque strip fixedly arranged on the outer wall of the inner tube, a torque block fixedly arranged on the inner wall of the first outer tube, a transmission nut and a reverse-thread nut which are in axial sliding fit with the torque strip, and the outer peripheries of the transmission nut and the reverse-thread nut are threadedly connected with the first outer tube and the second outer tube respectively. The thread-rotating direction between the reverse-thread nut and the second outer tube is opposite to the thread-rotating direction between the transmission nut and the first outer tube, and the inner tube is configured to be capable of rotating forward, thereby moving the reverse-thread nut upward to disengage from the second outer tube.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of angiotensinogen (AGT). In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT mRNA in a cell or animal. In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT protein in a cell or animal.

Abstract: Methods and systems for developing one or more lead alloy compositions based on a set of design objectives comprising receiving alloy composition data for one or more input alloys; identifying a set of the alloy composition features; determining the material behavior of each input alloy based on the set of alloy composition features; determining a plurality of candidate alloy compositions having material behavior conforming to a first subset of the design objectives; applying a multiscale simulation process to evaluate each candidate alloy composition; identifying, a first set of one or more simulated alloy compositions that satisfy the first subset of the design objectives; identifying, a second set of one or more simulated alloy compositions from the first set based on a second subset of design objectives; and validating each of the second set through experimental evaluation and determining the one or more lead alloy compositions.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of angiotensinogen (AGT). In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT mRNA in a cell or animal. In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT protein in a cell or animal.

Abstract: Described are novel targeting ligands that may be linked to compounds, such therapeutic compounds that are useful in directing the compounds to the in vivo target. The targeting ligands disclosed herein can serve to target expression-inhibiting oligomeric compounds, such as RNAi agents, to liver cells to modulate gene expression. The targeting ligands disclosed herein, when conjugated to a therapeutic compound, may be used in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Compositions including the targeting ligands disclosed herein when linked to expression-inhibiting oligomeric compounds are capable of mediating expression of target nucleic acid sequences in liver cells, such as hepatocytes, which may be useful in the treatment of diseases or conditions that respond to inhibition of gene expression or activity in a cell, tissue, or organism.

Abstract: A battery cell, a battery, and an electric apparatus are described. The battery cell includes a housing body, an electrode assembly, and a current collecting disc. The electrode assembly is installed in the housing body, and the electrode assembly is provided with a tab. The current collecting disc includes a first connecting piece and a second connecting piece, where the first connecting piece is mechanically connected to the second connecting piece, the first connecting piece is welded to the tab, and the second connecting piece is welded to the housing body. The first connecting piece is welded to the tab, the second connecting piece is welded to the housing body, and the first connecting piece is mechanically connected to the second connecting piece, which can prevent the occurrence of cracks due to welding of the first connecting piece to the second connecting piece to a certain extent.

Abstract: Disclosed is a cloud point measuring apparatus for a silicone surfactant, including a sewage discharge assembly, a heating and stirring assembly, and a detection assembly. Clear water in a transparent test tube is not contact with a solution in a detection bottle, so that the clear water always remains clear. Inner and outer contours of a piston block are tightly fitted against the transparent test tube and the detection bottle respectively, and a light-guiding layer is disposed in the interior of the piston block, so that the light-guiding layer can guide the color of the clear water to a surface of the detection bottle. When the color of the solution changes at a cloud point, test personnel or a visual detection device can determine that the cloud point of the silicone surfactant is reached based on the light-guiding layer and an obvious change in the color of the solution.

Abstract: An analysis method for bird behavior based on multi-frame fusion, including: performing a dual-channel monitoring and a frame rate fusion based on a monitoring device assembled inside a housing of a binocular bird feeder, to determine an image frame sequence, a behavior structure is defined in a lightweight geometric linear manner using a head-neck-beak of a bird as a basis for frame rate fusion. Constructing a behavior analysis module using behavioral semantics, behavioral micro-actions, and macroscopic composite behaviors as recognition dimensions, performing a dimension-parallel analysis and a statistical analysis on the image frame sequence to determine bird behavior data. Performing a periodic monitoring analysis and updating the bird behavior data, the bird behavior data that has stabilized is used as a behavior analysis result for display on a terminal interface.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training an image embedding model. In one aspect, a method comprises: obtaining training data comprising a plurality of training examples, wherein each training example comprises: an image pair comprising a first image and a second image; and selection data indicating one or more of: (i) a co-click rate of the image pair, and (ii) a similar-image click rate of the image pair; and using the training data to train an image embedding model having a plurality of image embedding model parameters.

Abstract: A bidirectional operation mechanism for a switching device and a switching device assembly. The bidirectional operation mechanism includes: a housing; an operation handle; a first driving member, rotatably installed to the housing, fixedly connected to the operation handle; a second driving member, rotatably installed to the housing, operatively connected to the first driving member and the switching device, upon an external force acting on the operation handle to drive the operation handle rotate between the closed position and the open position, the operation handle drives the first driving member to rotate together, so that the first driving member abuts against and drives the second driving member to rotate, enabling the switching device to perform a closing operation and an opening operation.

Abstract: An AI-enabled agent generates computer code based on a natural language description and by injecting predefined code blueprints. The technique includes determining, based on a natural language code description for an unwritten computer program, application parameters. A predefined prompt is identified based on the application parameters and fused with the natural language code description. One or more predefined code portions for the application parameters are identified. A code generation model is invoked using the fused predefined prompt and natural language code description, and the one or more predefined code portions to obtain an initial build of a program. A series of additional coding actions are performed based on a set of coding actions for generating the computer code, during which user feedback is solicited and checkpoints are performed.

Abstract: The present invention discloses a monitoring device for a production process of an organosilicon surfactant, which relates to the technical field of activator monitoring. The monitoring device comprises a tank body and a monitoring assembly; the monitoring assembly is arranged on one side of the tank body; the monitoring assembly comprises a sampling tube, a control valve, a sampling pump, an FEIR detecting device and a return tube; one side of the tank body is connected with the sampling tube; the control valve is connected in the middle of the sampling tube; the other end of the sampling tube is connected with the sampling pump; and one side of the sampling pump is connected with the FEIR detecting device through a pipeline.

Abstract: A system accesses metrics of features of workflows indicating an anomaly, the features represented as nodes in a graph and causal relationships as links, wherein a root node corresponds to the anomaly. The system, for each feature in each subgraph, computes an adjacent contribution score corresponding to each link for which the feature is a causing node, based on the metrics. The system determines a nonadjacent contribution score for each feature of the nodes in the graph to the anomaly by: assigning the adjacent contribution scores of features in a root subgraph of the multiple subgraphs that includes the root node to the corresponding features in the graph, for an adjacent subgraph of the multiple subgraphs that includes a shared feature that is also in the root subgraph, modifying the adjacent contribution scores of unique features of the adjacent subgraph based on the nonadjacent contribution score of the shared feature.

Abstract: A computerized method has the steps of: obtaining one or more first touches on a touch surface; and determining that the one or more first touches are resting on the touch surface if any of following first conditions is true: each first touch being contacting the touch surface without movement for longer than a first time duration, the one or more first touches being a plurality of first touches sequentially contacting the touch surface, the one or more first touches being a plurality of first touches contacting the touch surface substantially at a same time and remaining in contact with the touch surface for longer than a second time duration, the one or more first touches being in contact with the touch surface at one or more locations outside an input area or at one or more locations inside an resting area, or a combination thereof.

Abstract: Compounds having affinity for integrins, the synthesis of these compounds, and the use of these compounds as ligands to facilitate the delivery of cargo molecules to cells expressing integrins are described. The described integrin targeting ligands have serum stability and affinity for ?v?3 integrin and/or ?v?5 integrin, and are suitable for conjugation to cargo molecules, such as such as oligonucleotide-based therapeutic agents (e.g., RNAi agents), to facilitate delivery of the cargo molecules to cells and tissues, such as tumor cells, that express integrin ?v?3, integrin ?v?5, or both integrin ?v?3 and integrin ?v?5. Compositions that include integrin targeting ligands and methods of use are also described.

Abstract: Provided herein are CB1 ligand-containing compounds, methods of delivering said compounds, and methods of treating diseases, disorders, and symptoms (e.g., central nervous system diseases, disorders, and symptoms) in a subject using said compounds.

Abstract: Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a beta-ENaC (SCNN1B) gene. The beta-ENaC RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of a beta-ENaC gene. Pharmaceutical compositions that include one or more beta-ENaC RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described beta-ENaC RNAi agents to epithelial cells, such as pulmonary epithelial cells, in vivo, provides for inhibition of beta-ENaC gene expression and a reduction in ENaC activity, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including chronic obstructive pulmonary disease (COPD).