Abstract: Embodiments of the present disclosure generally relate to a system and method for enriching lithium (Li) from seawater and other low-grade lithium resources and eventually leading to the extraction of lithium from these resources. More particularly, the method involves decoupled electrochemical adsorptive and releasing processes using lithium selectively adsorptive/releasing electrode pair, and the two processes are interconnected through an oxidative/reductive electrode pair to transport lithium from the lithium extraction compartment to the lithium collection compartment.

Abstract: The present invention belongs to the technical field of pharmaceuticals and particularly relates to a rotigotine prodrug derivative, a pharmaceutical composition thereof and the use thereof in the preparation of a drug for preventing or treating diseases related to dopamine receptors. The rotigotine prodrug derivative is characterized by having a structure as represented by formula I): the rotigotine pro-drug derivative of the present invention is metabolized by esterase in vivo to produce rotigotine, such that the fluctuations in the plasma concentration of rotigotine are small and the maintenance time of the effective plasma concentration is long, thus enabling a reduction in the administration frequency and an improvement in patient compliance.

Abstract: The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit Angiopoietin-like 3 (also called ANGPTL3, ANGPL3, angiopoietin-like protein 3) gene expression, and compositions that include ANGPTL3 RNAi agents. Also disclosed are methods of use of ANGPTL3 RNAi agents and compositions. The ANGPTL3 RNAi agents disclosed herein may be conjugated to targeting ligands to facilitate the delivery to cells, including to hepatocytes. Pharmaceutical compositions that include one or more ANGPTL3 RNAi agents, optionally with one or more additional therapeutics, are described. Delivery of the ANGPTL3 RNAi agents in vivo provides for inhibition of ANGPTL3 gene expression, and can result in lower triglycerides and/or cholesterol levels in the subject. The RNAi agents can be used in methods of treatment of ANGPTL3-related diseases and disorders, including cardiometabolic diseases such as hypertriglyceridemia and hyperlipidemia.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of Complement Factor B (CFB). In certain aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of CFB mRNA in a. cell or animal. In certain aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of CFB protein in a cell or animal.

Abstract: The present disclosure provides a target object tracking method. In this disclosure, the point cloud data sequence in the target scene is collected by lidars and the first frame of cloud point data is extracted; the bounding box of the target object in the first frame of cloud point data is determined using the preset three-dimensional target tracking algorithm. All the target point clouds in the bounding box are extracted to generate the first template point cloud. The template expansion processing is performed using the preset ATG algorithm to obtain the second template point cloud. The point cloud features in the search area of other frames of point cloud data are extracted, and are compared with the second template point cloud and the reference template point cloud to obtain the comparison result. Based on the comparison result, the tracking result of the target object is generated and displayed.

Abstract: The present disclosure relates to a method, device, equipment and medium for inverse rendering an image. The method includes: inputting an image to be processed into a feature prediction model, predicting a geometric feature and a material feature of the image to be processed by the feature prediction mode to acquire a geometric feature map and a material feature map of the image to be processed, where the geometric feature map includes a normal map and a depth map, and the material feature map includes an albedo feature map, a roughness feature map, and a metalness feature map; inputting the image to be processed, the geometric feature map and the material feature map into a lighting prediction model, and predicting a lighting value of the image to be processed pixel by pixel by the lighting prediction model to acquire a lighting feature map of the image to be processed.

Abstract: Described are 5?-cyclo-phosphonate modified nucleotides, and oligonucleotides, such as interference (RNAi) agents, containing 5?-cyclo-phosphonate modified nucleotides. The RNAi agents having either double-stranded or single-stranded oligonucleotides described herein comprising 5?cyclo-phosphonate modified nucleotides are useful in modulating gene expression as well as therapeutic, diagnostic, target validation, and genomic discovery applications. The RNAi agents and single-stranded antisense oligonucleotides comprising 5?-cyclo-phosphonate modified nucleotides are useful in the treatment of diseases or conditions that respond to inhibition of gene expression or activity in a cell, tissue, or organism.

Abstract: A liner hanger includes an outer tube assembly, an inner tube and a torque transmitting assembly. The torque transmitting assembly has a torque strip fixedly arranged on the outer wall of the inner tube, a torque block fixedly arranged on the inner wall of the first outer tube, a transmission nut and a reverse-thread nut which are in axial sliding fit with the torque strip, and the outer peripheries of the transmission nut and the reverse-thread nut are threadedly connected with the first outer tube and the second outer tube respectively. The thread-rotating direction between the reverse-thread nut and the second outer tube is opposite to the thread-rotating direction between the transmission nut and the first outer tube, and the inner tube is configured to be capable of rotating forward, thereby moving the reverse-thread nut upward to disengage from the second outer tube.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of angiotensinogen (AGT). In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT mRNA in a cell or animal. In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT protein in a cell or animal.

Abstract: Methods and systems for developing one or more lead alloy compositions based on a set of design objectives comprising receiving alloy composition data for one or more input alloys; identifying a set of the alloy composition features; determining the material behavior of each input alloy based on the set of alloy composition features; determining a plurality of candidate alloy compositions having material behavior conforming to a first subset of the design objectives; applying a multiscale simulation process to evaluate each candidate alloy composition; identifying, a first set of one or more simulated alloy compositions that satisfy the first subset of the design objectives; identifying, a second set of one or more simulated alloy compositions from the first set based on a second subset of design objectives; and validating each of the second set through experimental evaluation and determining the one or more lead alloy compositions.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of angiotensinogen (AGT). In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT mRNA in a cell or animal. In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of AGT protein in a cell or animal.

Abstract: Described are novel targeting ligands that may be linked to compounds, such therapeutic compounds that are useful in directing the compounds to the in vivo target. The targeting ligands disclosed herein can serve to target expression-inhibiting oligomeric compounds, such as RNAi agents, to liver cells to modulate gene expression. The targeting ligands disclosed herein, when conjugated to a therapeutic compound, may be used in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Compositions including the targeting ligands disclosed herein when linked to expression-inhibiting oligomeric compounds are capable of mediating expression of target nucleic acid sequences in liver cells, such as hepatocytes, which may be useful in the treatment of diseases or conditions that respond to inhibition of gene expression or activity in a cell, tissue, or organism.

Abstract: A battery cell, a battery, and an electric apparatus are described. The battery cell includes a housing body, an electrode assembly, and a current collecting disc. The electrode assembly is installed in the housing body, and the electrode assembly is provided with a tab. The current collecting disc includes a first connecting piece and a second connecting piece, where the first connecting piece is mechanically connected to the second connecting piece, the first connecting piece is welded to the tab, and the second connecting piece is welded to the housing body. The first connecting piece is welded to the tab, the second connecting piece is welded to the housing body, and the first connecting piece is mechanically connected to the second connecting piece, which can prevent the occurrence of cracks due to welding of the first connecting piece to the second connecting piece to a certain extent.

Abstract: Disclosed is a cloud point measuring apparatus for a silicone surfactant, including a sewage discharge assembly, a heating and stirring assembly, and a detection assembly. Clear water in a transparent test tube is not contact with a solution in a detection bottle, so that the clear water always remains clear. Inner and outer contours of a piston block are tightly fitted against the transparent test tube and the detection bottle respectively, and a light-guiding layer is disposed in the interior of the piston block, so that the light-guiding layer can guide the color of the clear water to a surface of the detection bottle. When the color of the solution changes at a cloud point, test personnel or a visual detection device can determine that the cloud point of the silicone surfactant is reached based on the light-guiding layer and an obvious change in the color of the solution.

Abstract: An analysis method for bird behavior based on multi-frame fusion, including: performing a dual-channel monitoring and a frame rate fusion based on a monitoring device assembled inside a housing of a binocular bird feeder, to determine an image frame sequence, a behavior structure is defined in a lightweight geometric linear manner using a head-neck-beak of a bird as a basis for frame rate fusion. Constructing a behavior analysis module using behavioral semantics, behavioral micro-actions, and macroscopic composite behaviors as recognition dimensions, performing a dimension-parallel analysis and a statistical analysis on the image frame sequence to determine bird behavior data. Performing a periodic monitoring analysis and updating the bird behavior data, the bird behavior data that has stabilized is used as a behavior analysis result for display on a terminal interface.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training an image embedding model. In one aspect, a method comprises: obtaining training data comprising a plurality of training examples, wherein each training example comprises: an image pair comprising a first image and a second image; and selection data indicating one or more of: (i) a co-click rate of the image pair, and (ii) a similar-image click rate of the image pair; and using the training data to train an image embedding model having a plurality of image embedding model parameters.

Abstract: A bidirectional operation mechanism for a switching device and a switching device assembly. The bidirectional operation mechanism includes: a housing; an operation handle; a first driving member, rotatably installed to the housing, fixedly connected to the operation handle; a second driving member, rotatably installed to the housing, operatively connected to the first driving member and the switching device, upon an external force acting on the operation handle to drive the operation handle rotate between the closed position and the open position, the operation handle drives the first driving member to rotate together, so that the first driving member abuts against and drives the second driving member to rotate, enabling the switching device to perform a closing operation and an opening operation.

Abstract: An AI-enabled agent generates computer code based on a natural language description and by injecting predefined code blueprints. The technique includes determining, based on a natural language code description for an unwritten computer program, application parameters. A predefined prompt is identified based on the application parameters and fused with the natural language code description. One or more predefined code portions for the application parameters are identified. A code generation model is invoked using the fused predefined prompt and natural language code description, and the one or more predefined code portions to obtain an initial build of a program. A series of additional coding actions are performed based on a set of coding actions for generating the computer code, during which user feedback is solicited and checkpoints are performed.