Abstract: The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit 17?-hydroxysteroid dehydrogenase type 13 (HSD17B13 or 17?-HSD13) gene expression. Also disclosed are pharmaceutical compositions that include HSD17B13 RNAi agents and methods of use thereof. The HSD17B13 RNAi agents disclosed herein may be conjugated to targeting ligands to facilitate the delivery to cells, including to hepatocytes. Delivery of the HSD17B13 RNAi agents in vivo provides for inhibition of HSD17B13 gene expression. The RNAi agents can be used in methods of treatment of HSD17B13-related diseases and disorders, including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hepatic fibrosis, and alcoholic or non-alcoholic liver diseases, including cirrhosis.

Abstract: A system for gas extraction based on a non-solidifying sealing material, including a support assembly, a gas extraction pipe, a gas extraction device, two sealing water bags, a water injection and drainage device, a grouting device, a slurry discharge device, and a central control unit. The two sealing water bags are injected with water and expanded to offer a sealing effect. The grouting device is connected to a grouting pipe configured for injecting the non-solidifying sealing material into a sealing segment of a borehole. The slurry discharge device is configured to discharge slurry. The water injection and drainage device is configured to drain water from the two sealing water bags. The support assembly is recovered through a hook rod and an engagement hole. A gas extraction method using such system is also provided.

Abstract: Embodiments of the disclosure provides a contactor including a housing assembly and a buffer member. The housing assembly includes a first housing and a second housing which are installed together. The first housing is provided with a receiving cavity, a fixed core is installed in the receiving cavity, and a first limiting surface is formed on the fixed core. A fixed contact is installed on the second housing. The second housing includes a second limiting surface opposite to the first limiting surface, and the second limiting surface is provided with a groove. The buffer member is disposed in the groove and abuts against the first limiting surface.

Abstract: A method, system and processor for enhancing robustness of a source-code classification model based on invariant features is provided, wherein the method includes: combining non-robustness features to generate different style templates, converting codes in an input code training set into new codes of different styles to obtain a converted-code training set, merging the input-code and the converted-code training set into an expanded training set, and converting code texts in the expanded training set into code images; and converting the code images into required vectors, pairing samples of identical class randomly picked from the expanded training set and inputting the matched sample pairs into a feature extractor, iteratively updating the feature extractor and the matched sample pairs and extracting target characteristics, and training the extracted invariant features in a classifier to produce a trained model. The disclosed system includes a training set-expanding module and a model-training module.

Abstract: The present disclosure relates to a device for limiting movement of a movable part in electrical equipment and the electrical equipment including the same. The limiting device includes: a stopper provided in a moving path of the movable part and configured to contact the movable part at a predetermined position to prevent the movable part from moving; wherein the stopper is mainly formed of an elastomer and includes a stop surface, the elastomer being configured to be deformed when the movable part collides with the stop surface in a first direction; and wherein the elastomer further includes holes. With the holes being provided in the elastomer, impact resistance of the elastomer is enhanced, and performance deterioration of the elastomer due to a temperature rise is compensated.

Abstract: Methods and devices for managing output devices in a vehicle are disclosed. Data is obtained representing a sensed position of the first vehicle and a sensed feature in a proximity of the first vehicle. A first probability density function (PDF) is defined based on the obtained data, representing likelihood of a future position of the first vehicle. A second PDF is defined based on the obtained data, representing likelihood related to a proxemic risk presented by the sensed feature. A risk metric is computed representing a likelihood of the proxemic risk to the first vehicle based on an overlap between the first PDF and the second PDF. A useable number of information bits is determined, based on the risk metric. An application is controlled to provide output, via output device(s) of the first vehicle, within the useable number of information bits.

Abstract: An engineering bionic experimental system for evaluating an adaptive borehole plugging effect based on nuclear magnetic resonance (NMR) is provided and includes a drilling device, a high-field NMR device, an ultrasonic tomography imaging device, a plugging device, and a confining-pressure heating and cooling circulation device. A method for evaluating an adaptive borehole plugging effect based on NMR is provided and includes: preparing a sample, forming an underground simulated field; performing real-time dynamic imaging of fracture evolution surrounding a borehole during drilling; performing a first plugging, dynamic imaging of fracture filling surrounding the borehole, and a plugging effect evaluation, adjusting parameters of the underground simulated field to cause the first plugging to fail and to induce generation of new fractures or propagation of pre-existing fractures surrounding the plugged borehole; performing a secondary plugging; and repeating the above steps.

Abstract: Disclosed herein is a process for making a compound of formula (2) by (hetero)aromatic C—H hydroxylation of a compound of formula (1): catalyzed by palladium(II) and a bidentate ligand in the presence of O2. The process is useful for instance, in the late-stage modification of medicinally important heterocycles.

Abstract: It is an object of the invention to specify an electrically heatable reactor for hydrogen cyanide production and the production of other nitriles that enables a differentiated temperature profile and requires no more than inexpensive standard components. The core of the inventive apparatus (0) is a chamber (1) made of gas-permeable, thermally insulating material that constitutes the actual reaction space. Electrical heating elements (5) project into the chamber (1), such that the chamber (1) can be heated from the inside by the heating elements (5). The electrical terminals of the heating elements are outside the reaction space but within the surrounding shell. Unlike in the industrially implemented BMA process, the heat is thus not transported into the reaction space from the outside, but rather generated in the reaction space. The heat is generated by conversion of electrical energy by means of the heating elements (5) by the principle of resistance heating.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of plasma prekallikrein (PKK). In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of PKK mRNA in a cell or animal. In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of PKK protein in a cell or animal.

Abstract: The present application discloses a chip design method using secondary development capability of EDA software. On the basis of a chip having design and verification of a main function being completed, the feature steps comprise: customizing and adding, on an EDA software development platform, parameters required for an operating environment corresponding to the chip, automatically adding a schematic diagram of at least one of an environmental stabilization system used for implementing temperature compensation and an environmental stabilization system used for implementing electromagnetic shielding, combining same with a chip schematic diagram and drawing to obtain a layout.

Abstract: A roasting probe includes a probe head tube, a circuit board, a NTC thermistor, an antenna and a holding tube. The probe head tube includes a connection tube and a probe pin tube. The probe pin tube includes a shrunk portion, a transition portion and a cone-shaped portion that are consequently connected. The shrunk portion is connected to connection tube. The circuit board is provided with a limit part and is limited and provided in connection tube. An end of the circuit board away from probe pin tube is provided with a communication circuit. The NTC thermistor is connected to an end of circuit board facing probe pin tube and located inside transition section. The holding tube is made of ceramic and detachably provided at an end of connection tube away from probe pin tube. The antenna is electrically connected to communication circuit and located inside holding tube.

Abstract: Embodiments of the present disclosure generally relate to a system and method for enriching lithium (Li) from seawater and other low-grade lithium resources and eventually leading to the extraction of lithium from these resources. More particularly, the method involves decoupled electrochemical adsorptive and releasing processes using lithium selectively adsorptive/releasing electrode pair, and the two processes are interconnected through an oxidative/reductive electrode pair to transport lithium from the lithium extraction compartment to the lithium collection compartment.

Abstract: The present invention belongs to the technical field of pharmaceuticals and particularly relates to a rotigotine prodrug derivative, a pharmaceutical composition thereof and the use thereof in the preparation of a drug for preventing or treating diseases related to dopamine receptors. The rotigotine prodrug derivative is characterized by having a structure as represented by formula I): the rotigotine pro-drug derivative of the present invention is metabolized by esterase in vivo to produce rotigotine, such that the fluctuations in the plasma concentration of rotigotine are small and the maintenance time of the effective plasma concentration is long, thus enabling a reduction in the administration frequency and an improvement in patient compliance.

Abstract: The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit Angiopoietin-like 3 (also called ANGPTL3, ANGPL3, angiopoietin-like protein 3) gene expression, and compositions that include ANGPTL3 RNAi agents. Also disclosed are methods of use of ANGPTL3 RNAi agents and compositions. The ANGPTL3 RNAi agents disclosed herein may be conjugated to targeting ligands to facilitate the delivery to cells, including to hepatocytes. Pharmaceutical compositions that include one or more ANGPTL3 RNAi agents, optionally with one or more additional therapeutics, are described. Delivery of the ANGPTL3 RNAi agents in vivo provides for inhibition of ANGPTL3 gene expression, and can result in lower triglycerides and/or cholesterol levels in the subject. The RNAi agents can be used in methods of treatment of ANGPTL3-related diseases and disorders, including cardiometabolic diseases such as hypertriglyceridemia and hyperlipidemia.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of Complement Factor B (CFB). In certain aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of CFB mRNA in a. cell or animal. In certain aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of CFB protein in a cell or animal.

Abstract: The present disclosure provides a target object tracking method. In this disclosure, the point cloud data sequence in the target scene is collected by lidars and the first frame of cloud point data is extracted; the bounding box of the target object in the first frame of cloud point data is determined using the preset three-dimensional target tracking algorithm. All the target point clouds in the bounding box are extracted to generate the first template point cloud. The template expansion processing is performed using the preset ATG algorithm to obtain the second template point cloud. The point cloud features in the search area of other frames of point cloud data are extracted, and are compared with the second template point cloud and the reference template point cloud to obtain the comparison result. Based on the comparison result, the tracking result of the target object is generated and displayed.

Abstract: The present disclosure relates to a method, device, equipment and medium for inverse rendering an image. The method includes: inputting an image to be processed into a feature prediction model, predicting a geometric feature and a material feature of the image to be processed by the feature prediction mode to acquire a geometric feature map and a material feature map of the image to be processed, where the geometric feature map includes a normal map and a depth map, and the material feature map includes an albedo feature map, a roughness feature map, and a metalness feature map; inputting the image to be processed, the geometric feature map and the material feature map into a lighting prediction model, and predicting a lighting value of the image to be processed pixel by pixel by the lighting prediction model to acquire a lighting feature map of the image to be processed.

Abstract: Described are 5?-cyclo-phosphonate modified nucleotides, and oligonucleotides, such as interference (RNAi) agents, containing 5?-cyclo-phosphonate modified nucleotides. The RNAi agents having either double-stranded or single-stranded oligonucleotides described herein comprising 5?cyclo-phosphonate modified nucleotides are useful in modulating gene expression as well as therapeutic, diagnostic, target validation, and genomic discovery applications. The RNAi agents and single-stranded antisense oligonucleotides comprising 5?-cyclo-phosphonate modified nucleotides are useful in the treatment of diseases or conditions that respond to inhibition of gene expression or activity in a cell, tissue, or organism.

Abstract: A liner hanger includes an outer tube assembly, an inner tube and a torque transmitting assembly. The torque transmitting assembly has a torque strip fixedly arranged on the outer wall of the inner tube, a torque block fixedly arranged on the inner wall of the first outer tube, a transmission nut and a reverse-thread nut which are in axial sliding fit with the torque strip, and the outer peripheries of the transmission nut and the reverse-thread nut are threadedly connected with the first outer tube and the second outer tube respectively. The thread-rotating direction between the reverse-thread nut and the second outer tube is opposite to the thread-rotating direction between the transmission nut and the first outer tube, and the inner tube is configured to be capable of rotating forward, thereby moving the reverse-thread nut upward to disengage from the second outer tube.