Abstract: Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a beta-ENaC (SCNN1B) gene. The beta-ENaC RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of a beta-ENaC gene. Pharmaceutical compositions that include one or more beta-ENaC RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described beta-ENaC RNAi agents to epithelial cells, such as pulmonary epithelial cells, in vivo, provides for inhibition of beta-ENaC gene expression and a reduction in ENaC activity, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including chronic obstructive pulmonary disease (COPD).

Abstract: The present invention provides a bio-based succinic acid composition, a preparation method therefor, and use thereof. The bio-based succinic acid composition includes bio-based succinic acid and a readily oxidizable substance; and a content of the readily oxidizable substance in the bio-based succinic acid composition is ?0.32 mL/g. In the present invention, the bio-based succinic acid composition has a long shelf life, a small change in b value after aging, and good aging stability. Moreover, a polyester prepared from the bio-based succinic acid composition has a lower acid number, a whiter color, and a higher molecular weight.

Abstract: A gravity field interpolation method and device, and a storage medium are provided. The method includes: generating, by a server, sampling points in a grid corresponding to a satellite orbit; obtaining, by the server, coefficients of a polynomial based on measured values of the sampling points; and converting, by a client, an ECI coordinate at a reference time into a RTN coordinate corresponding to a grid cell, and normalizing the RTN coordinate to obtain a normalized RTN coordinate; and substituting the normalized RTN coordinate into the polynomial, calculating a gravitational acceleration before a J2 term of a spherical harmonic gravity field by using a spherical harmonic method, and calculating a gravitational acceleration after the J2 term of the spherical harmonic gravity field by using a polynomial interpolation method. The method can improve a calculation efficiency of a real-time orbit determination algorithm, and reduce a computational load of on-orbit data processing.

Abstract: A predictive control method of a grid-connected converter based on a structurally adaptive extended state observer (ESO) is provided. The method includes: obtaining data of a grid current and a grid voltage and converting the data to data in a dq coordinate system; calculating a selected voltage vector based on a voltage in the dq coordinate system; adaptively inputting the current in the dq coordinate system to a parallel ESO, a cascade ESO, or a hybrid cascade-parallel ESO, so as to obtain a current predicted current value and estimated total disturbance; carrying out a two-step grid current prediction based on the current predicted current value, the estimated total disturbance and the selected voltage vector; and taking minimizing a cost function as a control target, so as to obtain an optimal voltage vector based on a two-step grid current prediction result, and carrying out switching control of the grid-connected converter.

Abstract: A current collector comprises a current collector body, provided with a first side and a second side which are oppositely arranged, an opening passing through the first side and the second side being formed in the current collector body; and a blocking structure, which is arranged at the opening and is used for preventing solid particles from passing through the opening from the first side to move to the second side. The blocking structure facilitates an electrolyte to enter, via the current collector, a space above or below the current collector inside a casing, thus ensuring that the electrolyte wets an end of an electrode assembly and increasing the internal space utilization of the casing, and additionally, the blocking structure can prevent metal particles generated during a welding process of the current collector from entering the electrode assembly.

Abstract: A shower head with descaling ability includes: a housing provided with a plurality of nozzles; and a moving plate movably received in the housing and provided with a plurality of ejection pins configured to be inserted into the plurality of nozzles, respectively. The shower head is further provided with a first water inlet and a second water inlet, the water flowing into the first water inlet flows below the moving plate and drives the moving plate to move away from the nozzles, so that the ejection pins are disengaged from the nozzles and the water then flows out from the nozzles. The water flowing into the second water inlet flows above the moving plate and presses the moving plate to move towards the nozzles, so that the ejection pins are inserted into the nozzles to eject scales out of the nozzles.

Abstract: A display panel and a method for manufacturing the same, and a displaying device, which relates to the technical field of displaying. The display panel includes: a displaying substrate, a color light filtering layer disposed at a light exiting side of the displaying substrate. The color light filtering layer includes a first light filtering structure and a second light filtering structure of unequal thicknesses, orthographic projections of the light filtering structures on the displaying substrate cover corresponding positions of the light emitting region, and a surface of the first light filtering structure at one side away from the displaying substrate and a surface of the second light filtering structure at one side away from the displaying substrate are in a same plane.

Abstract: Disclosed is a method for constructing an optimal scheduling model of an integrated energy system considering virtual thermal storage, which relates to the technical field of electric power systems. The method includes: establishing an operation model of an apparatus, a demand response model of an energy load, a charging model of an electric vehicle, and an energy flow model of a heat supply network of the virtual thermal storage in the integrated energy system; processing, according to a second-order cone relaxation method, a direct current power flow model of a power distribution network, and constructing the optimal scheduling model of the integrated energy system by taking minimization of total cost of an energy operator as an objective, thereby coordinately and optimally scheduling a plurality of energy sources.

Abstract: The present invention discloses a pyrimidine-fused ring compound having an inhibitory effect on KRAS gene mutation, or a pharmaceutically acceptable salt, a stereoisomer, or a solvate thereof. Further, the present invention also discloses a pharmaceutical composition comprising the compound, and use thereof in the preparation of drugs against cancers.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training an image embedding model. In one aspect, a method comprises: obtaining training data comprising a plurality of training examples, wherein each training example comprises: an image pair comprising a first image and a second image; and selection data indicating one or more of: (i) a co-click rate of the image pair, and (ii) a similar-image click rate of the image pair; and using the training data to train an image embedding model having a plurality of image embedding model parameters.

Abstract: Provided is an extracorporeal circulation system, which includes an arterial sheath, an inflow tube, a handle, an outflow tube, and a venous sheath that are connected in sequence. The arterial sheath is used for connecting to a carotid artery, and the venous sheath is used for connecting to a vein. The handle includes a housing, as well as a flow controller, a blood filter, and a one-way check valve that are arranged in the housing and are communicated in sequence. The flow controller is connected to the end of the inflow tube away from the arterial sheath, and the one-way check valve is connected to the end of the outflow tube away from the venous sheath. The flow controller includes one body element with a flow-through channel and a flow control element. At least part of the flow control element is received in the body element and is movably connected to the flow-through channel. The flow control element reduces or increases the circulation area of the flow-through channel under an external force.

Abstract: Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of Complement Factor B (CFB). In certain aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of CFB mRNA in a cell or animal. In certain aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of CFB protein in a cell or animal.

Abstract: The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C—H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature.

Abstract: A method for authentication and related devices includes obtaining a first session key BS1 generated according to a set X and a set Y. The set X is a set of samples of received signal strength indicators (RSSIs) of a wireless channel of a user equipment (UE), and the set Y is a set of samples of RSSIs of a wireless channel of a vehicle. Upon receiving a second message from the UE, wherein the second message is hashed by a second session key BS2, extracting the second session key BS2 from the second message. When the first session key BS1 is the same as the second session key BS2, the authentication between the UE and the vehicle is successful.

Abstract: Compounds having affinity for integrins, the synthesis of these compounds, and the use of these compounds as ligands to facilitate the delivery of cargo molecules to cells expressing integrins are described. The described integrin targeting ligands have serum stability and affinity for ?v?3 integrin and/or ?v?5 integrin, and are suitable for conjugation to cargo molecules, such as such as oligonucleotide-based therapeutic agents (e.g., RNAi agents), to facilitate delivery of the cargo molecules to cells and tissues, such as tumor cells, that express integrin ?v?3, integrin ?v?5, or both integrin ?v?3 and integrin ?v?5. Compositions that include integrin targeting ligands and methods of use are also described.

Abstract: Described are methods for treating alpha-1 antitrypsin deficiency (AATD) in a human patient in need of treatment, using pharmaceutical compositions that include AAT RNAi agents. The pharmaceutical compositions disclosed herein that include AAT RNAi agents, when administered to a human patient in need thereof, treat liver diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, increased risk of hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, fulminant hepatic failure, and other liver-related diseases.

Abstract: The present application discloses a robot control method, a robot and a control terminal, which relate to the field of robot technology and can be used to improve the stability of the robot when there is a deviation between a desired posture and an actual posture of the robot. The robot control method includes calculating a first deviation between a current posture and the desired posture of the robot; updating dynamic parameters of the robot according to the first deviation; and obtaining a driving instruction of at least one joint module according to selected dynamic parameters to control the posture of the robot reaches or is close to the desired posture.

Abstract: The present disclosure relates to a display substrate, a display panel, a display device, and a manufacturing method of the display panel. The display substrate display substrate includes a display area, the display area including: a plurality of sides, wherein adjacent sides of the plurality of sides intersect to form a plurality of corners; a first display area having a first pixel density; and a second display area having a second pixel density lower than the first pixel density, wherein the second display area is located in at least one of the corners.

Abstract: The present application provides display substrates and their manufacturing methods, and display devices. A display substrate includes a base substrate, an encapsulation layer, a filter layer and optical film layers. The encapsulation layer is located on the base substrate. The filter layer is located in the encapsulation layer. The filter layer includes black matrixes. The black matrixes include black matrix openings. The optical film layers are located on a side of the encapsulation layer away from the base substrate. The optical film layers are configured to transmit part of incident light and absorb part of the incident light. A light transmittance of the optical film layers is larger than that of the black matrixes. The optical film layers include optical film layer openings. Projections of the optical film layer openings on the base substrate are located within projections of the black matrix openings on the base substrate.

Abstract: The present invention relates to the technical field of gravity energy storage, and in particular to a slope type gravity energy storage transmission device, including: a chain, provided with a lower gentle area, an ascending area and an upper gentle area; a connecting mechanism, including a connecting base, a locking frame slidingly, and a fastening plate; and an abutting mechanism, including a fixed plate and an inserting frame. According to the present invention, in the process of lifting a flexible trolley, the fastening plate is in a locked state without causing the separation of the inserting frame, so the separation phenomenon can be avoided, and the potential safety hazard can be reduced.