Abstract: The present invention relates generally to improved formulations of 6-thioguanine (6-TG), their methods of preparation, and their use in treatment methods. The invention provides a pharmaceutical composition including 6-TG, and a polyethylene oxide polymer having a molecular weight of between about 900,000 g/mol and about 9,000,000 g/mol, their methods of preparation, and their use in methods for treating a disease or condition of the distal intestine that responds to 6-TG, wherein the 6-TG is released in the distal intestine.

Abstract: A transparent sclera-based corneal repair material, and a preparation method and use thereof, belonging to the technical field of medical repair materials are disclosed. The sclera, a natural biological material that is convenient to obtain, is used as a source of the corneal repair material. The opaque sclera is hyalinized by compressing. Carboxyl groups on a scleral fibrin are activated by cross-linking, such that amino groups of the sclera combine with the carboxyl groups to form an amide bond. The amide bond belongs to a covalent bond and has a desirable stability, thereby maintaining a transparency of the sclera after the compressing. Therefore, the transparent sclera can be used as a transparent corneal tissue repair material.

Abstract: Embodiments of the present disclosure provide a color film substrate, a method for manufacturing the same and a display device. The color film substrate includes a substrate including a plurality of first recesses extending in a first direction, respectively, a plurality of first tabs arranged alternately with the plurality of first recesses in a second direction perpendicular to the first direction, a plurality of first black matrix strips disposed at least partially on the plurality of first tabs, respectively and extending in the first direction, and a color resist layer disposed in the plurality of first recesses and in gaps among the plurality of first black matrix strips.

Abstract: A color film substrate includes a base substrate, a black matrix layer, a color-resist layer, a protective layer, and a supporting post layer that are stacked and provided in sequence; the black matrix layer is provided with light-transmitting windows distributed in an array, and the color-resist layer covers each light-transmitting window; the supporting post layer is provided with a supporting post; the color film substrate includes a plurality of different subregions; in at least part of the subregions, the color-resist layer is provided with a partition slot located between rows of light-transmitting windows and exposing the black matrix layer, and an orthographic projection of the supporting post on the base substrate at least partially overlaps with an orthographic projection of the partition slot on the base substrate; in at least two of the subregions, the partition slot is provided with different widths.

Abstract: Described is a rectal suppository. The rectal suppository comprises 6-thioguanine, at least one hard fat, and at least one surfactant. Further or alternatively, the rectal suppository comprises about 1 to 9 mg of 6-thioguanine. Further or alternatively, there is described a method of preventing, treating and/or managing inflammatory bowel disease in a subject. The method comprises administering a rectal suppository to the subject in need thereof. Further or alternatively, there is described a method of manufacturing a rectal suppository. The method comprises the steps of (a) heating a hard fat to become a liquid hard fat, (b) adding at least one surfactant to the liquid hard fat, (c) adding 6-thioguanine to the liquid hard fat, (d) forming the hard fat into a rectal suppository. Step (b) is optionally carried out before step (c) or after step (c).

Abstract: Embodiments of the present disclosure provide a color film substrate and a method for preparing the same, and a display device. The color film substrate comprises a substrate; a first black matrix located on the substrate; and a second black matrix partially overlapping with the first black matrix, wherein at an overlapping position of the first black matrix and the second black matrix, the second black matrix overlays the first black matrix in a direction perpendicular to the substrate, and wherein a size of an opening defined by either of the first black matrix and the second black matrix is larger than a size of an opening defined by the first black matrix and the second black matrix together.

Abstract: A doped diamond particle-based three-dimensional electrode for water treatment and a preparation method therefor are provided. A boron-doped diamond plate electrode is used as an anode electrode, a titanium plate is used as a cathode electrode, and doped diamond particles are used as a filler that is assembled to form a filler module. The doped diamond particles include a core material, and a doped diamond film coating the core material. The doping element is one or more selected from boron, nitrogen, phosphorus, and lithium; and the core material is at least one selected from diamond particles, boron-doped diamond particles, metal particles, and ceramic particles. Doped diamond particles having a loose porous structure are used as a filler, to greatly increase the electrochemical active area and the adsorbable area.

Abstract: A cable-type welding wire provided in the present application, includes a central welding wire and n peripheral welding wires arranged so as to be spirally wound on the central welding wire, with each of the peripheral welding wires having a diameter of dperipheral, and adjacent peripheral welding wires being arranged to be tangential to each other, wherein, the peripheral welding wires have a lay length of T, which satisfies the equation of T=m×(dperipheral+dcentral)/2, where m is a multiple of the lay length, dperipheral is a diameter of the peripheral welding wire, dcentral is a diameter of the central welding wire, and 3.2?m<20. This application can obtain a smaller penetration depth when the welding parameters remain constant due to a small multiple of the lay length of the cable-type welding wire, and can further reduce welding arcing current.

Abstract: Provided herein are combination therapies comprising a KRasG12C inhibitor (e.g. GDC-6036) and an PI3K-inhibitor (e.g. inavolisib) and methods of using such combination therapies.

Abstract: The present disclosure relates to an optical sensing system and an analog-to-digital converter. The optical sensing system includes a ramp signal generator, a digital logic circuit and a plurality of column circuits. The ramp signal generator is configured to generate a ramp signal and transmit the ramp signal to the column circuits. The ramp signal includes a signal of which a signal intensity varies with time, and a signal intensity variation rate of the ramp signal corresponds to an amplification factor of a photosensitive electric signal. Each column circuit is configured to receive photosensitive electric signal, and output a photosensitive gain signal to the digital logic circuit according to ramp signal and photosensitive electric signal. Photosensitive gain signal includes a digital signal corresponding to photosensitive electric signal of which signal intensity is amplified. The digital logic circuit is configured to calculate a digital sampling signal according to photosensitive gain signals.

Abstract: A method for manufacturing a component carrier includes covering a dielectric layer structure by a metal foil, forming an electroless metal layer on the metal foil, and forming a multi-stage electroplating structure on the electroless metal layer. A component carrier made by the method is further described.

Abstract: A composite hydrogel contains alginate hydrogel and acellular matrix hydrogel. The ingredients used to produce the acellular matrix hydrogel contains acellular matrix and transglutaminases (TGases). The alginate hydrogel contains salginate complex. The alginate hydrogel and acellular matrix hydrogel constitute a three-dimensional crosslinking structure. The TGases can catalyze isopeptide bonding between acellular matrixes, and thus forms acellular matrix hydrogel through crosslinking.

Abstract: A method for preparing a CeOx coating on a surface of a substrate includes depositing a CeOx coating on the surface by means of a reactive magnetron sputtering from a pure cerium target. The CeOx coating can be transparent for visible light. A method for reducing the adhesion of a tissue material such as from a human to a surface of a medical instrument, for reducing the water condensation and improving the heat transfer performance of a heat exchanger surface of a substrate, and for reducing corrosion of a surface of a substrate includes depositing a CeOx coating on the substrate by means of a reactive magnetron sputtering from a pure cerium target. This provides an environmentally friendly preparation of the CeOx coating with no need for organic solvents or volatile organic compounds. The CeOx coating has good hydrophobicity, enhanced hardness, exceptionally high wear resistance, and superior thermal stability.

Abstract: A cable-type welding wire provided in the present application, includes a central welding wire and n peripheral welding wires arranged so as to be spirally wound on the central welding wire, with each of the peripheral welding wires having a diameter of dperipheral, and adjacent peripheral welding wires being arranged to be tangential to each other, wherein, the peripheral welding wires have a lay length of T, which satisfies the equation of T=m×(dperipheral+dcentral)/2, where m is a multiple of the lay length, dperipheral is a diameter of the peripheral welding wire, dcentral is a diameter of the central welding wire, and 3.2?m<20. This application can obtain a smaller penetration depth when the welding parameters remain constant due to a small multiple of the lay length of the cable-type welding wire, and can further reduce welding arcing current.

Abstract: A method of manufacturing component carriers is disclosed. The method includes supplying a panel with a plurality of semifinished component carriers, to an automatic optical inspection unit for automatic optical inspection by comparison of a data set indicative of an actual image of a respective semifinished component carrier with a data set indicative of a reference image, forwarding the inspected panel to an automatic judgment unit for carrying out a quality classification of the semifinished component carriers, based on a result of the automatic optical inspection, by applying artificial intelligence, and taking an action based on the quality classification.