Patents by Inventor Zhen Yan

Zhen Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10919837
    Abstract: The present invention concerns a process for forming a primary or a secondary amine via amination reaction comprising: reacting an alcohol with an amine in the presence of a zeolite comprising a transition metal chosen in the group consisting of Group 8 to 12 elements of the Periodic Table and any combination thereof.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: February 16, 2021
    Assignee: RHODIA OPERATIONS
    Inventors: Lin Fang, Zhen Yan, Javier Diaz-Maroto Carpintero
  • Publication number: 20210009706
    Abstract: The present invention provides an anti-CD27 antibody, an antigen-binding fragment thereof, and a medical use thereof. Specifically, the present invention provides a human antibody comprising the CDR region of the anti-CD27 antibody, and a pharmaceutical composition comprising the human anti-CD27 antibody and an antigen-binding fragment thereof, and a use thereof as an anticancer drug. In particular, the invention provides a human anti-CD27 antibody and a use thereof in the preparation of a drug for the treatment of CD27-mediated diseases or disorders.
    Type: Application
    Filed: March 27, 2019
    Publication date: January 14, 2021
    Inventors: Hao Huang, Yan Fang, Zhen Yan, Ruijun Shi, Jiahua Jiang, Guoqing Cao, Lianshan Zhang
  • Publication number: 20210008155
    Abstract: Provided are methods for prophylaxis and/or therapy for Phelan-McDermid Syndrome (PMS) and autism spectrum disorder (ASD). The methods involve administering a hi stone methyltransf erase (HMT) inhibitor, a hi stone deacetylase (HDAC) inhibitor, or a combination thereof, such that one or more symptoms of the PMS and/or the AMD are reduced.
    Type: Application
    Filed: December 20, 2017
    Publication date: January 14, 2021
    Inventor: Zhen YAN
  • Publication number: 20210000954
    Abstract: A stable anti-PD-1 antibody pharmaceutical preparation and an application thereof in a medicine. The anti-PD-1 antibody pharmaceutical preparation comprises an anti-PD-1 antibody, a buffer, and can further comprise at least one type of stabilizer, and optionally can further con a surfactant. The anti-PD-1 antibody pharmaceutical preparation of the present invention can effectively suppress antibody aggregation and deamidation, thereby preventing degradation of an antibody product, obtaining a stable injected pharmaceutical preparation.
    Type: Application
    Filed: September 2, 2020
    Publication date: January 7, 2021
    Inventors: Jie Li, Zhen Yan, Pingping Wang, Yan Fang, Weikang Tao, Lianshan Zhang, Piaoyang Sun
  • Patent number: 10786567
    Abstract: A stable anti-PD-1 antibody pharmaceutical preparation and an application thereof in a medicine. The anti-PD-1 antibody pharmaceutical preparation comprises an anti-PD-1 antibody, a buffer, and can further comprise at least one type of stabilizer, and optionally can further comprise a surfactant. The anti-PD-1 antibody pharmaceutical preparation of the present invention can effectively suppress antibody aggregation and deamidation, thereby preventing degradation of an antibody product, resulting in a stable injectable pharmaceutical preparation.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: September 29, 2020
    Assignees: Suzhou Suncediabiopharmaeuticals Co., Ltd., Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Jie Li, Zhen Yan, Pingping Wang, Yan Fang, Weikang Tao, Lianshan Zhang, Piaoyang Sun
  • Publication number: 20200199209
    Abstract: A pharmaceutical composition containing an SOST antibody or an antigen-binding fragment thereof in an acetic acid-sodium acetate buffer solution is described. In addition, the pharmaceutical composition can also contain sugar, a nonionic surfactant or other excipients. After being stored for several months, the pharmaceutical composition exhibits good antibody stability.
    Type: Application
    Filed: July 26, 2018
    Publication date: June 25, 2020
    Inventors: Jingjing FANG, Zhen YAN, Xun LIU
  • Publication number: 20200181702
    Abstract: The present disclosure provides a panel of nucleic acid molecule primers specific for HLA-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious disease, allograft rejection, or pregnancy-related pathologies.
    Type: Application
    Filed: February 19, 2020
    Publication date: June 11, 2020
    Inventors: J. Lee Nelson, Nathalie C. Lambert, Vijayakrishna K. Gadi, Zhen Yan
  • Publication number: 20200181701
    Abstract: The present disclosure provides a panel of nucleic acid molecule primers specific for HLA-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious disease, allograft rejection, or pregnancy-related pathologies.
    Type: Application
    Filed: February 19, 2020
    Publication date: June 11, 2020
    Inventors: J. Lee Nelson, Nathalie C. Lambert, Vijayakrishna K. Gadi, Zhen Yan
  • Publication number: 20200129633
    Abstract: A stable c-Met antibody-drug conjugate (c-Met ADC) formulation and use thereof in medicine are described. In particular, the formulation contains c-Met ADC, a buffer, and can also contains at least one stabilizer, and optionally a surfactant. The c-Met ADC formulation of the application can effectively inhibit the aggregation and isomerization of antibodies, and prevent the degradation of an antibody product therein, being a stable injectable pharmaceutical formulation.
    Type: Application
    Filed: June 5, 2018
    Publication date: April 30, 2020
    Inventors: Jingjing FANG, Zhen YAN, Guimei TONG, Xun LIU
  • Patent number: 10604805
    Abstract: The present disclosure provides a panel of nucleic acid molecule primers specific for HLA-specific alleles and other genetic polymorphisms, which are useful for quantitatively amplifying these markers to detect, diagnose, and monitor individuals who have or are at risk of certain disease conditions, such as autoimmune disease, proliferative disease, infectious disease, allograft rejection, or pregnancy-related pathologies.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: March 31, 2020
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: J. Lee Nelson, Nathalie C. Lambert, Vijayakrishna K. Gadi, Zhen Yan
  • Publication number: 20200069800
    Abstract: The present invention provides a PD-L1 antibody pharmaceutical composition and use thereof. In particular, the present invention provides a pharmaceutical composition comprising the PD-L1 antibody or an antigen-binding fragment thereof in a succinate buffer. In addition, the pharmaceutical composition may also contain a sugar and a nonionic surfactant.
    Type: Application
    Filed: May 15, 2018
    Publication date: March 5, 2020
    Inventors: Zhen Yan, Jianjian Yang, Xiaodan Yan, Shan Wu, Xun Liu
  • Patent number: 10458937
    Abstract: The present invention discloses an electromagnetic detector and a detection method for detection of interface cracks in a piezoelectric-piezomagnetic laminated structure. The electromagnetic detector for detection of interface crack in a piezoelectric-piezomagnetic laminated structure mainly comprises an eddy current magnetic probe assembly, an automatic scanning frame, a base, a carrier, a servomotor, an X-axis mobile frame driving controller, a Y-axis mobile frame driving controller, a power supply, and a main controller.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: October 29, 2019
    Inventors: Wenjie Feng, Zhen Yan, Peng Ma, Lei Wen
  • Publication number: 20190277786
    Abstract: The present invention d iscloses an electromagnetic detector and a detection method for detection of interface cracks in a piezoelectric-piezomagnetic laminated structure. The electromagnetic detector for detection of interface crack in a piezoelectric-piezomagnetic laminated structure mainly comprises an eddy current magnetic probe assembly, an automatic scanning frame, a base, a carrier, a servomotor, an X-axis mobile frame driving controller, a Y-axis mobile frame driving controller, a power supply, and a main controller.
    Type: Application
    Filed: March 8, 2018
    Publication date: September 12, 2019
    Inventors: WENJIE FENG, ZHEN YAN, PENG MA, LEI WEN
  • Publication number: 20190159427
    Abstract: A feeding and weight resistance apparatus for an animal that includes a platform configured to move in response to lifting force exerted by the animal onto the platform; a food repository configured to store food; and a feeding interface. The feeding interface may be configured to: impair food to be dispensed in response to retrieval force exerted by the animal, and regulate food dispensed from the food repository for a predetermined duration in response to the lifting force exerted by the animal toward the platform. A method of feeding and applying weight resistance for an animal. A method of diagnosing or evaluating an animal using the feeding and weight lifting apparatus and method for the study and application in the field of biomedicine, including but not limited thereto, the field of exercise physiology.
    Type: Application
    Filed: September 19, 2016
    Publication date: May 30, 2019
    Applicant: University of Virginia Patent Foundation
    Inventor: Zhen Yan
  • Publication number: 20190071389
    Abstract: The present invention concerns a process for forming a primary or a secondary amine via amination reaction comprising: reacting an alcohol with an amine in the presence of a zeolite comprising a transition metal chosen in the group consisting of Group 8 to 12 elements of the Periodic Table and any combination thereof.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 7, 2019
    Applicant: RHODIA OPERATIONS
    Inventors: Lin FANG, Zhen YAN, Javier DIAZ-MAROTO CARPINTERO
  • Patent number: 10207980
    Abstract: Providing a process for forming an amine, such as a primary, a secondary or a tertiary amine, via the direct amination of an alcohol using a catalyst comprising at least a palladium compound on a support comprising cerium oxide.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: February 19, 2019
    Assignee: RHODIA OPERATIONS
    Inventors: Zhen Yan, Marc Pera Titus, Armin T. Liebens
  • Publication number: 20180339045
    Abstract: A stable anti-PD-1 antibody pharmaceutical preparation and an application thereof in a medicine. The anti-PD-1 antibody pharmaceutical preparation comprises an anti-PD-1 antibody, a buffer, and can further comprise at least one type of stabilizer, and optionally can further comprise a surfactant. The anti-PD-1 antibody pharmaceutical preparation of the present invention can effectively suppress antibody aggregation and deamidation, thereby preventing degradation of an antibody product, resulting in a stable injectable pharmaceutical preparation.
    Type: Application
    Filed: September 14, 2016
    Publication date: November 29, 2018
    Inventors: Jie LI, Zhen YAN, Pingping WANG, Yan FANG, Weikang TAO, Lianshan ZHANG, Piaoyang SUN
  • Publication number: 20170320811
    Abstract: Providing a process for forming an amine, such as a primary, a secondary or a tertiary amine, via the direct amination of an alcohol using a catalyst comprising at least a palladium compound on a support comprising cerium oxide.
    Type: Application
    Filed: November 10, 2014
    Publication date: November 9, 2017
    Applicants: RHODIA OPERATIONS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Zhen YAN, Marc PERA TITUS, Armin T. LIEBENS
  • Patent number: 9663446
    Abstract: Disclosed is a process for preparing a primary, a secondary or a tertiary amine via the direct amination of an alcohol in the presence of a catalyst. The catalyst is composed of palladium or a palladium compound and a cerium oxide supporter.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: May 30, 2017
    Assignees: RHODIA OPERATIONS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Zhen Yan, Mohamad Ousmane, Marc Pera-Titus, Floryan DeCampo
  • Publication number: 20160244401
    Abstract: Disclosed is a process for preparing a primary, a secondary or a tertiary amine via the direct amination of an alcohol in the presence of a catalyst. The catalyst is composed of palladium or a palladium compound and a cerium oxide supporter.
    Type: Application
    Filed: October 15, 2013
    Publication date: August 25, 2016
    Inventors: Zhen YAN, Mohamad OUSMANE, Marc PERA-TITUS, Floryan DECAMPO