Abstract: Embodiments of the present disclosure provide a datum selection method for minimizing hole position errors in group hole machining of large components, comprising: 1) determining a type of a computer numerical control (CNC) machine tool and establishing a topological structure of the CNC machine tool; 2) establishing a theoretical postural model of a tool center point during a motion; 3) establishing a hole position error model; 4) establishing an average error model of hole positions in group hole machining; and 5) obtaining a machining datum for group holes of corresponding components. For the skeleton and skinned group hole machining of aircraft components, different principles of datum selection are provided respectively, which can effectively improve the positional accuracy of the skeleton or skinned group hole machining, at the same time provides a more scientific and reasonable approach for the datum selection in group hole machining of large components.

Abstract: The present invention relates to a new formulation, which is a soft chewy confection for-mulation, which comprises at least one Human Milk Oligosaccharides (HMOs).

Abstract: The present invention relates to a new formulation (a non-effervescent tablet) comprising Human Milk Oligosaccharides (HMOs), which dissolves or can be dispersed in water (or water based liquids) fast. The tablets are when dissolved can be consumed easily by a human.

Abstract: Embodiments of the present disclosure provide a datum selection method for minimizing hole position errors in group hole machining of large components, comprising: 1) determining a type of a computer numerical control (CNC) machine tool and establishing a topological structure of the CNC machine tool; 2) establishing a theoretical postural model of a tool center point during a motion; 3) establishing a hole position error model; 4) establishing an average error model of hole positions in group hole machining; and 5) obtaining a machining datum for group holes of corresponding components. For the skeleton and skinned group hole machining of aircraft components, different principles of datum selection are provided respectively, which can effectively improve the positional accuracy of the skeleton or skinned group hole machining, at the same time provides a more scientific and reasonable approach for the datum selection in group hole machining of large components.

Abstract: The present invention relates to a new fast dissolvable tablet comprising physiologically active ingredients, which dissolves or can be dispersed in water (or water based liquids) fast.

Abstract: The present invention relates to a solid oral dosage form comprising naproxen and vitamin B6. Preferably, it is a solid oral dosage form for use in the treatment of pain such as low back pain. It is a fixed-dose combination (FDC) which increases patient compliance. The method of preparing such solid oral dosage form comprises the extragranular addition of vitamin B6 to an intragranular composition, wherein said intragranular composition comprises naproxen or a pharmaceutically acceptable salt thereof and at least one binder.

Abstract: The present invention relates to a solid oral dosage form comprising naproxen and vitamin B1. Preferably, it is a solid oral dosage form for use in the treatment of pain such as low back pain. It is a fixed-dose combination (FDC) which increases patient compliance. The method of preparing such solid oral dosage form comprises the preparation of naloxone granules, the intragranular addition of vitamin B1 and optionally the extragranular addition of other B-vitamins such vitamin B6 and vitamin B12.

Abstract: The present invention relates to a solid oral dosage form comprising naproxen and vitamin B12. Preferably, it is a solid oral dosage form for use in the treatment of pain such as low back pain. It is a fixed-dose combination (FDC) which increases patient compliance. The method of preparing such solid oral dosage form comprises the extragranular addition of vitamin B12 to an intragranular composition, wherein said intragranular composition comprises naproxen or a pharmaceutically acceptable salt thereof and at least one binder.

Abstract: The present invention is related to specific coated non-frozen aerated confectionery, which are fortified with specific nutrients. More particularly it relates to non-frozen aerated confectionery, such as a marshmallow.

Abstract: The present invention relates to a new formulation comprising L-theanine.

Abstract: The invention comprises neutral multi-functionality assemblies of pharmaceuticals comprising an active medicinal functionality, a transition metal functionality, and an ancillary ligand functionality. An exemplary series of mixed-ligand coordination complexes comprised of copper(II), a drug and an ancillary ligand were made and tested. It is demonstrated that the judicious choice of an ancillary ligand affords a large degree of control over die relative lipophilicity/hydrophilicity of the complex in relation to the uncomplexed drug molecule. The important factors to be considered in the design of such complexes, such as the additive-constitutive nature of the partition coefficient of the ancillary ligand and the relative size of the two types of ligands are disclosed, and methods of designing neutral multi-functionality assemblies of pharmaceuticals are disclosed.