Patents by Inventor Zhendong Jin

Zhendong Jin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210196675
    Abstract: A use of one or more of a Ginkgo biloba terpene lactone compound or a pharmaceutically acceptable salt, ester, hydrate, solvate, or isomer thereof, or any crystal form, racemate, or metabolite of same, or a mixture of same as an active ingredient in the preparation of drugs for the prevention and/or treatment of tremors, and healthcare products. The Ginkgo biloba terpene lactone compound and composition can both significantly improve the disease condition of essential tremor model mice; the ameliorating effect of a Ginkgo biloba terpene lactone B and bilobalide composition and a ginkgolide A, ginkgolide B, and ginkgolide C composition on the essential tremor model mice is close to that of the positive control drug propranolol hydrochloride. The disease condition of patients with essential tremors and patients with vascular tremors is significantly improved, and there have been no adverse reactions in clinical observations.
    Type: Application
    Filed: May 24, 2019
    Publication date: July 1, 2021
    Inventors: YI SUN, HUIQIN LI, ZHENDONG JIN
  • Publication number: 20190153021
    Abstract: The invention provides compounds of formula (I): and salts thereof, wherein R1, R2, R3, B, X, Y, and Z have any of the values defined herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for preparing compounds of formula (I) and salts thereof, intermediates useful for preparing compounds of formula (I) and salts thereof, and therapeutic methods for treating cancer using a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 6, 2016
    Publication date: May 23, 2019
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Zhendong Jin, Yan Mei, Lei Chen, Aashay Sha
  • Patent number: 9346781
    Abstract: The invention provides compounds useful as anti-cancer agents.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: May 24, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Zhendong Jin, Lei Chen
  • Publication number: 20150210664
    Abstract: The invention provides compounds useful as anti-cancer agents.
    Type: Application
    Filed: July 25, 2013
    Publication date: July 30, 2015
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Zhendong Jin, Lei Chen
  • Patent number: 7102020
    Abstract: The present invention provides a method to prepare 2H-benzo[6]pyrans, such as the anti-HIV natural product daurichromenic acid (1a), by microwave-assisted tandem aldol reaction of a phenolic enolate followed by intramolecular SN2? type cyclization to form the 2H-benzo[6]pyran core structure.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: September 5, 2006
    Inventors: Zhendong Jin, Ying Kang
  • Publication number: 20050004044
    Abstract: The present invention concerns methods for treating pancreatic cancers, leukemias, colon cancers, malignant gliomas and other brain tumors, and ovarian cancers which comprise providing to an individual compositions comprising an orsaponin such as OSW-1 or its derivatives such as 17-deoxyorsaponin. Various therapeutically useful derivatives of orsaponins are also described.
    Type: Application
    Filed: April 7, 2004
    Publication date: January 6, 2005
    Inventors: Peng Huang, Michael Keating, Zhendong Jin
  • Publication number: 20040192762
    Abstract: The present invention provides a method to prepare 2H-benzo[6]pyrans, such as the anti-HIV natural product daurichromenic acid (1a), by microwave-assisted tandem aldol reaction of a phenolic enolate followed by intramolecular SN2′ type cyclization to form the 2H-benzo[6]pyran core structure.
    Type: Application
    Filed: December 18, 2003
    Publication date: September 30, 2004
    Inventors: Zhendong Jin, Ying Kang
  • Patent number: 6753414
    Abstract: A process for preparing compounds of formula (1): including the convergent steps as defined in the specification, and wherein R groups have any of the values defined in the specification. The invention also provides processes and intermediates useful for preparing compounds of formula (1).
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: June 22, 2004
    Assignee: University of Iowa Research Foundation, Inc.
    Inventors: Zhendong Jin, Wensheng Yu
  • Publication number: 20030069214
    Abstract: A process for preparing compounds of formula (1): 1
    Type: Application
    Filed: August 6, 2002
    Publication date: April 10, 2003
    Inventors: Zhendong Jin, Wensheng Yu