Patents by Inventor Zhenfa Zhang

Zhenfa Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors
    Patent number: 9649301
    Abstract: Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: May 16, 2017
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda Dwoskin, Guangrong Zheng, Sangeetha Sumithran, David Allen, Zhenfa Zhang, Paul Lockman
  • Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
    Patent number: 9550753
    Abstract: Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and gastrointestinal tract disorders.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: January 24, 2017
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Zhenfa Zhang
  • Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors
    Publication number: 20150352088
    Abstract: Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Application
    Filed: August 18, 2015
    Publication date: December 10, 2015
    Inventors: Peter Crooks, Linda Dwoskin, Guangrong Zheng, Sangeetha Sumithran, David Allen, Zhenfa Zhang, Paul Lockman
  • Tetrakis-quaternary ammonium salts and methods for modulating neuronal nicotinic acteylcholine receptors
    Patent number: 8629163
    Abstract: Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: January 14, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda P. Dwoskin, Zhenfa Zhang, Marharyta Pivavarchyk
  • Use of a Novel Alpha-7 Nachr Antagonist to Suppress Pathogenic Signal Transduction in Cancer and Aids
    Publication number: 20130231366
    Abstract: This application provides a method for the use of select quaternary ammonium antagonists to alpha-7 nAChR for the treatment of cancer and HIV and AIDS.
    Type: Application
    Filed: February 20, 2013
    Publication date: September 5, 2013
    Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Roger L. PAPKE, Peter A. CROOKS, Linda P. DWOSKIN, Gretchen Lopez HERNANDEZ, Zhenfa ZHANG, Jeffrey S. THINSCHMIDT, Guangrong ZHENG
  • -quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
    Patent number: 8178678
    Abstract: Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: May 15, 2012
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda P. Dwoskin, Guangrong Zheng, Zhenfa Zhang, Sangeetha Sumithran, Marharyta Pivavarchyk
  • USE OF A NOVEL ALPHA-7 nAChR ANTAGONIST TO SUPPRESS PATHOGENIC SIGNAL TRANSDUCTION IN CANCER AND AIDS
    Publication number: 20100179186
    Abstract: This application provides a method for the use of select quaternary ammonium antagonists to alpha-7 nAChR for the treatment of cancer and HIV and AIDS.
    Type: Application
    Filed: October 13, 2009
    Publication date: July 15, 2010
    Applicant: University of Kentucky Research Foundation
    Inventors: Roger L. PAPKE, Peter A. CROOKS, Linda P. DWOSKIN, Gretchen Lopez HERNANDEZ, Zhenfa ZHANG, Jeffrey S. THINSCHMIDT, Guangrong ZHENG
  • TETRAKIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACTEYLCHOLINE RECEPTORS
    Publication number: 20090143424
    Abstract: Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Application
    Filed: October 29, 2008
    Publication date: June 4, 2009
    Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: PETER A. CROOKS, Linda P. Dwoskin, Zhenfa Zhang, Marharyta Pivavarchyk