Patents by Inventor ZHENFEI XIE

ZHENFEI XIE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Androgenetic haploid embryonic stem cell (AG-HAESC), and preparation method and use thereof
    Patent number: 11330806
    Abstract: The present invention relates to an AG-haESCs in which H19 DMR and IG-DMR are knocked out, a method for preparing the AG-haESCs, and use of the AG-haESCs in constructing a genetically modified semi-cloned animal and a library of a genetically modified semi-cloned animal. The AG-haESCs is capable of obtaining characteristics resembling a round spermatid, and upon injection into an oocyte, a viable SC mouse is stably obtained. The present invention is capable of being effectively used in multi-gene genetic manipulation, advancing the acquisition of animals with multiple genetic modifications.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: May 17, 2022
    Assignee: CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES
    Inventors: Jinsong Li, Yuxuan Wu, Cuiqing Zhong, Qi Yin, Zhenfei Xie, Meizhu Bai
  • ANDROGENETIC HAPLOID EMBRYONIC STEM CELL, AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20180251728
    Abstract: The present invention relates to an AG-haESCs in which H19 DMR and IG-DMR are knocked out, a method for preparing the AG-haESCs, and use of the AG-haESCs in constructing a genetically modified semi-cloned animal and a library of a genetically modified semi-cloned animal. The AG-haESCs is capable of obtaining characteristics resembling a round spermatid, and upon injection into an oocyte, a viable SC mouse is stably obtained. The present invention is capable of being effectively used in multi-gene genetic manipulation, advancing the acquisition of animals with multiple genetic modifications.
    Type: Application
    Filed: July 2, 2015
    Publication date: September 6, 2018
    Applicant: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES CHINESE ACADEMY OF SCIENCES
    Inventors: JINSONG LI, YUXUAN WU, CUIQING ZHONG, QI YIN, ZHENFEI XIE, MEIZHU BAI