Patents by Inventor Zhenfu Han

Zhenfu Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, METHODS OF MAKING, AND METHODS OF USE THEREOF
    Publication number: 20230192728
    Abstract: Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed.
    Type: Application
    Filed: July 13, 2022
    Publication date: June 22, 2023
    Applicant: Washington University
    Inventors: Michael J. Holtzman, Arthur G. Romero, Benjamin J. Gerovac, Zhenfu Han, Shamus P. Keeler, Kangyun Wu
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20230033327
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: August 26, 2022
    Publication date: February 2, 2023
    Inventors: James W. JANETKA, Zhenfu HAN, Scott HULTGREN, Jerry PINKER, CORINNE CUSUMANO
  • Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
    Patent number: 11407771
    Abstract: Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: August 9, 2022
    Assignee: Washington University
    Inventors: Michael J. Holtzman, Arthur G. Romero, Benjamin J. Gerovac, Zhenfu Han, Shamus P. Keeler, Kangyun Wu
  • INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES
    Publication number: 20220169676
    Abstract: The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
    Type: Application
    Filed: September 14, 2021
    Publication date: June 2, 2022
    Applicant: Washington University
    Inventors: James W. Janetka, Zhenfu Han, Peter Harris, Partha Karmakar
  • Inhibitors of growth factor activation enzymes
    Patent number: 11130780
    Abstract: The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: September 28, 2021
    Assignee: Washington University
    Inventors: James W. Janetka, Zhenfu Han, Peter Harris, Partha Karmakar
  • MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, METHODS OF MAKING, AND METHODS OF USE THEREOF
    Publication number: 20210214378
    Abstract: Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 15, 2021
    Applicant: Washington University
    Inventors: Michael J. Holtzman, Arthur G. Romero, Benjamin J. Gerovac, Zhenfu Han, Shamus P. Keeler, Kangyun Wu
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20210122776
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: December 28, 2020
    Publication date: April 29, 2021
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20190211045
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 11, 2019
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • Compounds and methods for treating bacterial infections
    Patent number: 10273260
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 30, 2019
    Assignee: WASHINGTON UNIVERSITY
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20180194792
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: March 8, 2018
    Publication date: July 12, 2018
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • Compounds and methods for treating bacterial infections
    Patent number: 9957289
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: May 1, 2018
    Assignee: WASHINGTON UNIVERSITY
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES
    Publication number: 20180066015
    Abstract: The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
    Type: Application
    Filed: March 2, 2016
    Publication date: March 8, 2018
    Applicant: Washington University
    Inventors: James W. Janetka, Zhenfu Han, Peter Harris, Partha Karmakar
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20170247401
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Application
    Filed: December 8, 2016
    Publication date: August 31, 2017
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • Compounds and methods for treating bacterial infections
    Patent number: 9567362
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: February 14, 2017
    Assignee: WASHINGTON UNIVERSITY
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20160145289
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: May 30, 2014
    Publication date: May 26, 2016
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20150197538
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Application
    Filed: December 15, 2014
    Publication date: July 16, 2015
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • Compounds and methods for treating bacterial infections
    Patent number: 8937167
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: January 20, 2015
    Assignee: Washington University
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20120309701
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Application
    Filed: April 23, 2012
    Publication date: December 6, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano