Abstract: Negative Poisson's ratio (NPR) or auxetic are used to make lightweight wheels and runflat tires. The NPR tires can be tailored and functionally-designed to optimally meet the runflat requirements for both military and commercial vehicles. NPR-runflat tires may be fabricated using standard materials and simple manufacturing processes, resulting in low-cost and high-volume production. In preferred embodiments the runflat tire designs are fully compatible with Central Tire Inflation Systems (CTIS), while providing a performance equivalent to current military vehicle solutions but at half the weight. An auxetic wheel according to the invention comprises a line defining an axis of rotation; and a plurality of concentric rings of unit cells surrounding the axis, each unit cell being constructed of a plurality of members defining a Negative Poisson's Ratio (NPR) structure.

Abstract: Biomimetic tendon-reinforced” (BTR) composite structures feature improved properties including a very high strength-to-weight ratio. A basic structure comprises a plurality of spaced-apart stuffer members, each having a first end and a second end defining a length. A plurality of tendon elements interconnect with the first and second ends of the stuffer members in alternating fashion, such that the tendon elements criss-cross each other between the stuffer members. A first panel is bonded or attached to the first ends of the stuffer members, and a second panel is bonded or attached to the second ends of the stuffer members. In the preferred embodiments, the first panel, the second panel, or both the first and second panels are curved. An efficient manufacturing process based upon hollow stuffers and tendon elements in the form of bent wires is also disclosed.

Abstract: Negative Poisson's ratio (NPR) or auxetic structures, including three-dimensional auxetic structures, are disclosed and applied to various applications. One such structure comprises a pyramid-shaped unit cell having four base points A, B, C, and D defining the corners of a square lying in a horizontal plane. Four stuffers of equal length or different lengths extend from a respective one of the base points to a point E spaced apart from the plane. Four tendons of equal length or different lengths, but less than that of the stuffers, extend from a respective one of the base points to a point F between point E and the plane. In three-dimensional configurations, a plurality of unit cells are arranged as tiles in the same horizontal plane with the base points of each cell connected to the base points of adjoining cells, thereby forming a horizontal layer.

Abstract: A latching element includes a main section having a first end and a second end opposite thereto, a connecting portion formed on the edge of the first end, a locking portion formed on the second end; and a shaft spaced from the main section. The present disclosure also discloses a method of manufacturing the latching element and a portable electronic device having the latching element.

Abstract: Stents of the type used to treat and prevent localized flow constriction in body vessels are based upon negative Poisson's ratio (NPR) structures. An auxetic stent constructed in accordance with this invention comprises a tubular structure having two ends defining a length with a central longitudinal axis and an axial view defining a cross section. The tubular structure is composed of a plurality of unit cells with two different configurations, called V-type and X-type. In V-type auxetic stents, each unit cell comprises a pair of side points A and B defining a width, a first pair of members interconnecting points A and B and intersecting at a point C forming a first V shape, and a second pair of members interconnecting points A and B and intersecting at a point D forming a second V shape. In X-type auxetic stents, each unit cell comprises eight points from A to H defining an outline of the unit cell.

Abstract: The present invention discloses novel benzamide derivatives represented by general formula (I), their preparation, pharmaceutical compositions containing the derivatives and their use as medicament, especially as a 5-HT4 stimulator, wherein the definition of each substituent of the general formula (I) is the same as defined in the description.

Abstract: Negative Poisson's ratio (NPR) or auxetic structures, including three-dimensional auxetic structures, are disclosed and applied to various applications. One such structure comprises a pyramid-shaped unit cell having four base points A, B, C, and D defining the corners of a square lying in a horizontal plane. Four stuffers of equal length or different lengths extend from a respective one of the base points to a point E spaced apart from the plane. Four tendons of equal length or different lengths, but less than that of the stuffers, extend from a respective one of the base points to a point F between point E and the plane. In three-dimensional configurations, a plurality of unit cells are arranged as tiles in the same horizontal plane with the base points of each cell connected to the base points of adjoining cells, thereby forming a horizontal layer.

Abstract: Improved composite armor designs uses optimally shaped ceramic pellets, a specific stacking geometry and a web system for patterning the pellets, improving manufacturability, and providing additional structural reinforcement. Lightweight, composite ballistic armor according to the invention may comprise an array of ceramic pellets, each pellet having a front surface, a back surface and a longitudinal centerline, and wherein the front surface of each pellet is intentionally convex. The front surface of each pellet may be hemispherical, in which case the cross-section of the pellet taken perpendicular to the centerline may be oval-shaped. Alternatively, the front surface of each pellet may be elliptical, in which case the cross-section of the pellet taken perpendicular to the centerline may be circular. In the preferred embodiment, the back surface of each pellet is formed at the same angle relative to its centerline, with the pellets being arranged with the flat surfaces lying in a plane.

Abstract: Improved composite armor designs uses optimally shaped ceramic pellets, a specific stacking geometry and a web system for patterning the pellets, improving manufacturability, and providing additional structural reinforcement. Lightweight, composite ballistic armor according to the invention may comprise an array of ceramic pellets, each pellet having a front surface, a back surface and a longitudinal centerline, and wherein the front surface of each pellet is intentionally convex. The front surface of each pellet may be hemispherical, in which case the cross-section of the pellet taken perpendicular to the centerline may be oval-shaped. Alternatively, the front surface of each pellet may be elliptical, in which case the cross-section of the pellet taken perpendicular to the centerline may be circular. In the preferred embodiment, the back surface of each pellet is formed at the same angle relative to its centerline, with the pellets being arranged with the flat surfaces lying in a plane.

Abstract: A latching element includes a main section having a first end and a second end opposite thereto, a connecting portion formed on the edge of the first end, a locking portion formed on the second end; and a shaft spaced from the main section. The present disclosure also discloses a method of manufacturing the latching element and a portable electronic device having the latching element.

Abstract: The levelling rod (1) for a level determining apparatus (2) has position indications therealong along expressed by barcode symbols (11, 12). At least some of said barcode symbols are color barcode symbols, the color serving to encode said position indications. The barcode symbols can be organised in first and second blocks (12, 11) of barcode symbols, each providing a position indication, wherein the length (Ls) occupied along the rod (1) by a first block (12) is smaller than the length (Lb) occupied along the rod by a second block (11), the first blocks thereby providing a finer position indication than the second blocks. The first blocks (12) of barcode symbols can be formed of monochrome and color bar code symbols, e.g. just one color barcode symbol and at least one monochrome barcode symbol, while the second blocks (11) can be formed purely of color barcode symbols. The invention also relates to a level determining apparatus specifically adapted for the above rod, and to a method of using that rod.

Abstract: Biomimetic tendon-reinforced” (BTR) composite structures feature improved properties including a very high strength-to-weight ratio. The basic structure includes plurality of parallel, spaced-apart stuffer members, each with an upper end and a lower end, and a plurality of fiber elements, each having one point connected to the upper end of a stuffer member and another point connected to the lower end of a stuffer member such that the elements form criss-crossing joints between the stuffer members. The stuffer members and fiber elements may optionally be embedded in a matrix material such as an epoxy resin. The fiber elements are preferably carbon fibers, though other materials, including natural or synthetic fibers or metal wires may be used. The stuffer members may be rods, tubes, or spheres, and may be constructed of metal, ceramic or plastic. The stuffer members are preferably spaced apart at equal distances. If the members are tubes, the fiber elements may be dressed through the tubes.

Abstract: Improved composite armor designs use optimally shaped ceramic pellets and a web system for patterning the pellets, improving manufacturability, and providing additional structural reinforcement. The result is lightweight, composite hybrid structures for ballistic protection particularly suited to tactical ground vehicles. The preferred embodiment is a combination of three major components: 1) an optimally designed web system that allows armor tiles to be attached to it and that can be easily integrated with existing vehicle structures; 2) an advanced composite armor unit using a patent-pending BTR (Bio-mimetic Tendon-Reinforced) material as the supporting structure; and 3) optimally placed “waiting materials” which can provide enhanced ballistic impact resistance, energy absorption capability and structural integrity. These “waiting materials” are structural members that are not active at the beginning of the ballistic impact, but become active when needed or the active members have failed.

Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.

Abstract: The invention relates to novel derivatives of 4-phenylthiazoles and 4-phenylimidizoles and the use thereof as medicaments. The invention especially relates to the following compounds: butyl-2-[4-(4-aminophenyl)-1H-imidizol-2-yl]ethyl-carbamate, and 4-[2-(1-aminocyclopentyl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol, and the salts of the same.

Abstract: The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pharmaceutical compositions comprising said analogues alone or in combination with a bisphosphonate or calcitonin.

Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues.

Abstract: Improved composite armor designs use optimally shaped ceramic pellets and a web system for patterning the pellets, improving manufacturability, and providing additional structural reinforcement. The result is lightweight, composite hybrid structures for ballistic protection particularly suited to tactical ground vehicles. The preferred embodiment is a combination of three major components: 1) an optimally designed web system that allows armor tiles to be attached to it and that can be easily integrated with existing vehicle structures; 2) an advanced composite armor unit using a patent-pending BTR (Bio-mimetic Tendon-Reinforced) material as the supporting structure; and 3) optimally placed “waiting materials” which can provide enhanced ballistic impact resistance, energy absorption capability and structural integrity. These “waiting materials” are structural members that are not active at the beginning of the ballistic impact, but become active when needed or the active members have failed.

Abstract: The invention features targeted cytotoxic compounds and methods relating to their therapeutic use for the treatment of neoplasia and other conditions.

Abstract: The invention relates to novel derivatives of 4-phenylthiazoles and 4-phenylimidazoles and the use thereof medicament. The invention especially relates to the following compounds: butyl-2-[4-(4-(aminophenyl)-1<i>H</i>-imidazol-2-yl]ethyl-carbamate, and 4-[2-(1-aminocyclopentyl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol, and the salts of the same.