Abstract: Provided herein are rearranged during transfection (RET) fusion nucleic acid molecules and RET fusion polypeptides, methods related to detecting RET fusion nucleic acid molecules and RET fusion polypeptides in cancer, as well as methods of treatment and uses related thereto. Detection of a RET fusion nucleic acid molecule or a RET fusion polypeptide can be used to identify individuals that may benefit from treatment with an anti-cancer therapy.

Abstract: Provided herein are methods related to treating or delaying progression of osteosarcoma in an individual. In some embodiments, the methods comprise detecting an FGFR1-MTSS1 or TACC1-FGFR1 gene fusion in one or more samples from an individual having a cancer; and administering to the individual an effective amount of a treatment that comprises an anti-cancer agent.

Abstract: Methods for predicting an origin of an alteration of a sample are described. The methods may comprise, for example, receiving, using one or more processors, sequence read data associated with the sample, selecting, using the one or more processors, a plurality of reads from the sequence read data based on the alteration, determining, using the one or more processors, at least one feature characterizing the selected plurality of reads, inputting, using the one or more processors, the at least one feature into a statistical model, generating, using the one or more processors, a score indicative of the origin of the alteration by the statistical model, and predicting, using the one or more processors, the origin of the alteration in the sample by comparing the score and one or more predefined thresholds.

Abstract: Disclosed herein are methods and systems for determining an origin of viral sequence reads detected in a sample (e.g., a liquid biopsy sample) from an individual. The sample may contain cfDNA fragments of varying fragment lengths. Embodiments of the present disclosure can receive sequence read data associated with the sample, which may be a liquid biopsy sample. The sequence read data can be used to determine if one or more viral sequence reads are detected in the sample. If the viral sequence reads are detected, the system can determine one or more fragmentomic features based on the sequence read data. The system can then generate an output indicative of the origin of the viral sequence reads by inputting the fragmentomic features into a statistical model including, for example, a trained machine-learning model. Based on the output, the system can then determine whether the viral sequence reads originate from a tumor.

Abstract: Provided herein are CD274 rearrangements. CD274 nucleic acid molecules, and PD-L1 polypeptides methods related to detecting CD274 rearrangements. CD274 nucleic acid molecules, and PD-L1 polypeptides in cancer, as well as methods of treatment and uses related thereto. Detection of CD274 rearrangements. CD274 nucleic acid molecules, and PD-L1 polypeptides of the disclosure can be used to identify individuals that may benefit from treatment with an anti-cancer therapy such as an immune checkpoint inhibitor.

Abstract: An image-recognition-based control method includes calling an imaging device of a shooting device to collect an environment image of an environment where the shooting device is currently located; calling a preset human-body-feature-part detection model to perform image area identification on the environment image to provide an identification result; and prohibiting a shooting member of the shooting device from shooing, in response to the identification result indicating that the environment image contains a target image area including a preset human-body-feature-part.

Abstract: A remote control vehicle includes a vehicle body and an acoustic vibration detection device. The vehicle body includes a protection cover. The acoustic vibration detection device is located at a side of the protection cover away from an external surface of the protection cover and configured to detect acoustic vibration generated when the protection cover is hit by an external object. The acoustic vibration detection device includes a housing body, a damping assembly, and an acoustic sensor. The housing body includes a chamber. The acoustic sensor includes a microphone arranged in the chamber through the damping assembly.

Abstract: The position of an object displayed in a virtual world is determined from the user-controlled position of a corresponding physical object in a physical environment. The position of the physical object is fixed using markers in the physical environment when enough such markers are available, but with a secondary navigation system otherwise, or with both. Position fixing, both relative and absolute, may also be carried out optically, independent of any corresponding virtual world.