Patents by Inventor Zheng Ouyang

Zheng Ouyang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8766178
    Abstract: A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure.
    Type: Grant
    Filed: October 2, 2012
    Date of Patent: July 1, 2014
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Liang Gao, Robert Graham Cooks
  • Publication number: 20140158882
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Application
    Filed: February 14, 2014
    Publication date: June 12, 2014
    Applicant: Purdue Research Foundation
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • Publication number: 20140141466
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Application
    Filed: January 9, 2014
    Publication date: May 22, 2014
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Ahmed M. Hamid, Alan K. Jarmusch, Zheng Ouyang
  • Publication number: 20140138540
    Abstract: The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides systems for analyzing a sample that include an electric source, a vacuum chamber including a conducting member, in which the conducting member is coupled to the electric source, a sample introduction member coupled to the vacuum chamber, and a mass analyzer. The system is configured such that a distal end of the sample introduction member resides within the vacuum chamber and proximate the conducting member, such that an electrical discharge may be produced between the sample introduction member and the conducting member. A neutral gas that has been introduced into the vacuum chamber interacts with the generated discharge, producing ions within the vacuum chamber that are subsequently transferred into the mass analyzer in the vacuum chamber.
    Type: Application
    Filed: October 21, 2013
    Publication date: May 22, 2014
    Applicant: Purdue Research Foundation
    Inventors: Zheng Ouyang, Chen Tsung-Chi
  • Patent number: 8710437
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: April 29, 2014
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Patent number: 8704167
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: April 22, 2014
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Patent number: 8686351
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: April 1, 2014
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • Publication number: 20140048697
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Application
    Filed: September 11, 2013
    Publication date: February 20, 2014
    Applicant: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Publication number: 20140011282
    Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.
    Type: Application
    Filed: August 26, 2013
    Publication date: January 9, 2014
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Zheng Ouyang, Jason Harper, Nicholas Charipar, Robert Graham Cooks
  • Publication number: 20140008532
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
    Type: Application
    Filed: September 12, 2013
    Publication date: January 9, 2014
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Publication number: 20140008529
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
    Type: Application
    Filed: September 11, 2013
    Publication date: January 9, 2014
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Publication number: 20130344610
    Abstract: The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides a system for analyzing a sample that includes a probe including a material connected to a high voltage source, a device for generating a heated gas, and a mass analyzer.
    Type: Application
    Filed: December 29, 2011
    Publication date: December 26, 2013
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Robert Graham Cooks, Guangtao Li, Xin Li, Zheng Ouyang
  • Publication number: 20130330714
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.
    Type: Application
    Filed: June 25, 2013
    Publication date: December 12, 2013
    Inventors: Robert Graham Cooks, Ahmed Mohamed Hamid, Alan Keith Jarmusch, Zheng Ouyang
  • Patent number: 8592756
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: November 26, 2013
    Assignee: Purdue Research Foundation
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • Publication number: 20130292564
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Application
    Filed: July 9, 2013
    Publication date: November 7, 2013
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • Patent number: 8519354
    Abstract: The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: August 27, 2013
    Assignee: Purdue Research Foundation
    Inventors: Nicholas Charipar, Jason Harper, Zheng Ouyang, Robert Graham Cooks
  • Publication number: 20130181010
    Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.
    Type: Application
    Filed: March 4, 2013
    Publication date: July 18, 2013
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu
  • Publication number: 20130146759
    Abstract: The invention generally relates to improved sensitivity and flexibility for mass spectrometers with limited pumping capacity, particularly mass spectrometers that are coupled with a Discontinuous Atmospheric Pressure Interface (DAPI).
    Type: Application
    Filed: February 25, 2011
    Publication date: June 13, 2013
    Inventors: Zheng Ouyang, Robert Graham Cooks, Keyong Hou
  • Publication number: 20130126723
    Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.
    Type: Application
    Filed: December 27, 2012
    Publication date: May 23, 2013
    Inventors: Zheng Ouyang, Robert Graham Cooks, Sandilya Venkata Garimella, Jason David Harper, Nicholas Alan Charipar
  • Publication number: 20130112867
    Abstract: The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
    Type: Application
    Filed: December 26, 2012
    Publication date: May 9, 2013
    Inventors: Zheng Ouyang, He Wang, Nicholas E. Manicke, Robert Graham Cooks, Qian Yang, Jiangjiang Liu