Abstract: Disclosed is a sub-Kelvin temperature zone refrigeration mechanism. The sub-Kelvin temperature zone refrigeration mechanism includes a pulse tube refrigeration unit, first pre-cooling heat exchangers, a throttling refrigeration unit, second pre-cooling heat exchangers, an adsorption refrigeration unit, a third pre-cooling heat exchanger and a dilution refrigeration unit. The pulse tube refrigeration unit includes a pulse tube refrigeration part. The throttling refrigeration unit includes a throttling refrigeration part, and the throttling refrigeration part is connected with the adsorption refrigeration unit through the second pre-cooling heat exchangers so as to pre-cool the adsorption refrigeration unit. The adsorption refrigeration unit includes an adsorption refrigeration part, and the adsorption refrigeration part is connected with the dilution refrigeration unit through the third pre-cooling heat exchanger.

Abstract: Various embodiments are disclosed for providing machine learning routines with peripheral device data to infer driver activity and location. Peripheral device data may be collected on a peripheral device having a machine learning routine executing thereon to infer driver activity and perform improved estimation of driver location. Using driver activity and location estimation, contextually relevant delivery workflow assistance may be automatically provided to a delivery driver or other individual without requiring manual input, thereby improving driver safety and operational efficiency.

Abstract: The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Abstract: An image processing method and an image processing apparatus are provided. In the method, first encoding is performed on an input image, to output a first noisy image. De-noising is performed on the first noisy image, to output a first de-noised image. De-noising is performed on the input image according to the first de-noised image, to output a first image.

Abstract: The present disclosure relates to a method, apparatus and system for determining accessible paths between two nodes. According to the method of the present disclosure, an adjacency matrix of a graph, which includes a plurality of points and edges connecting the plurality of points, is first established; then, search is made for an accessible path that can reach a destination from a starting point based on the adjacency matrix. Especially, a termination condition for the searching is set based on an already-sought path during the searching, and the corresponding search is terminated in response to the termination condition being met during the searching. With the present disclosure, it may substantially reduce repeated traversal, obvious reduce the time taken to search for accessible paths between two nodes, and significantly improve the efficiency in searching for the accessible path.

Abstract: The invention provides a bispecific antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention provides a nucleic acid encoding the antibody construct, a vector comprising the nucleic acid and a host cell transformed or transfected with the vector. Furthermore, the invention provides a process for the production of the bispecific antibody construct, a medical use of the antibody construct and a kit comprising the antibody construct. The bispecific antibody construct may be useful in the treatment of melanoma.

Abstract: Embodiments of the present disclosure relate to a method, apparatus and computer readable storage medium for data processing. The method may include obtaining a causal result determined based on reference data of a plurality of reference factors. The plurality of reference factors may include a reference satisfaction degree and other reference factors, and the causal result may include a causal relationship between the reference satisfaction degree and the other reference factors and a causal relationship between the other reference factors. The method may further include obtaining sample data of a plurality of user factors associated with a user, the plurality of user factors at least partially overlapping the other reference factors. The method may further include determining a first satisfaction degree of the user based on the sampled data and the causal result.

Abstract: A computing circuit and a data processing method based on a convolutional neural network and a computer readable storage medium are provided. Input data is obtained from a memory. A first computation is performed on first part data of the input data to obtain first output data. The first output data is buffered in a first buffer. When the buffered first output data is greater than a first predetermined data amount, a second computation is performed on the first output data to obtain second output data. The second output data is buffered in a second buffer. Third output data obtained by performing a third computation on the second output data is output to the memory. When performing the second computation on the first output data, the first computation is continuously performed on the input data. Accordingly, the number of accesses of the memory can be reduced.

Abstract: The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

Abstract: Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods allow one to correct and/or compensate for confounding variables such as hematocrit, salt concentration and/or temperature before providing an analyte concentration. The measurement methods use response information from a test sequence having at least one DC block, where DC block includes at least one excitation pulse and at least one recovery pulse, and where a closed circuit condition of an electrode system is maintained during the at least one recovery pulse. Information encoded in the excitation and recovery pulses are used to build within- and across-pulse descriptors to correct/compensate for hematocrit, salt concentration and/or temperature effects on the analyte concentration. Methods of transforming current response data also are disclosed. Further disclosed are devices, apparatuses and systems incorporating the various measurement methods.

Abstract: The present disclosure relates to a method, apparatus, device and storage medium for information processing. Specifically, a method is proposed for information processing. In the method, multiple observation samples associated with multiple factors of an application system are received, an observation sample among the multiple observation samples comprising a group of observation values of the multiple factors. At least one attribute of the multiple observation samples is obtained. At least one processing procedure is determined based on the at least one attribute, a processing procedure of the at least one processing procedure being used for processing the multiple observation samples to obtain a causality between the multiple factors. Further, there is provided an apparatus, device and storage medium for information processing. Based on input data to be processed, an algorithm for processing the input data may be automatically determined.

Abstract: Embodiments of the present disclosure relate to a method, a device and a computer-readable storage medium for data analysis. The method comprises: generating, at least based on historical conditional data associated with a historical factor affecting a historical event and historical result data, an association between the historical factor and a result of the historical event, the historical result data indicating the result of the historical event caused by the historical factor; determining at least one target result of interest selected for a current event, the current event being associated with the historical event; determining a current factor affecting the current event and at least one target object associated with the at least one target result of interest; and determining data of the at least one target result of interest at least based on the association, current conditional data associated with the current factor and the at least one target object.

Abstract: The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

Abstract: The present disclosure relates to a method, apparatus and system for determining accessible paths between two nodes. According to the method of the present disclosure, an adjacency matrix of a graph, which includes a plurality of points and edges connecting the plurality of points, is first established; then, search is made for an accessible path that can reach a destination from a starting point based on the adjacency matrix. Especially, a termination condition for the searching is set based on an already-sought path during the searching, and the corresponding search is terminated in response to the termination condition being met during the searching. With the present disclosure, it may substantially reduce repeated traversal, obvious reduce the time taken to search for accessible paths between two nodes, and significantly improve the efficiency in searching for the accessible path.

Abstract: Disclosed herein are antigenic peptide-MHC molecules, termed comPACTs, and methods of producing such molecules. Also disclosed herein are methods of producing libraries of comPACT polynucleotides and polypeptides, and their exemplary use in capturing cancer neoepitope-reactive T cells.

Abstract: Disclosed herein are antigenic peptide-MHC molecules, termed comPACTs, and methods of producing such molecules. Also disclosed herein are methods of producing libraries of comPACT polynucleotides and polypeptides, and their exemplary use in capturing cancer neoepitope-reactive T cells.

Abstract: Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods further allow one to correct and/or compensate for confounding variables such as hematocrit (Hct), temperature or both before providing an analyte concentration. The measurement methods utilize information obtained from test sequences having at least one AC block and at least one pulsed DC block, where pulsed DC block includes at least one recovery potential, and where a closed circuit condition of the electrode system is maintained during the DC block. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods.

Abstract: The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Abstract: Disclosed herein are antigenic peptide-MHC molecules, termed comPACTs, and methods of producing such molecules. Also disclosed herein are methods of producing libraries of comPACT polynucleotides and polypeptides, and their exemplary use in capturing cancer neoepitope-reactive T cells.

Abstract: Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods allow one to correct and/or compensate for confounding variables such as hematocrit, salt concentration and/or temperature before providing an analyte concentration. The measurement methods use response information from a test sequence having at least one DC block, where DC block includes at least one excitation pulse and at least one recovery pulse, and where a closed circuit condition of an electrode system is maintained during the at least one recovery pulse. Information encoded in the excitation and recovery pulses are used to build within- and across-pulse descriptors to correct/compensate for hematocrit, salt concentration and/or temperature effects on the analyte concentration. Methods of transforming current response data also are disclosed. Further disclosed are devices, apparatuses and systems incorporating the various measurement methods.