Patents by Inventor Zheng Tan

Zheng Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240059693
    Abstract: The present invention relates to novel Fused Bicyclic Pyrazole Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and R6 are as defined herein. The present invention also relates to compositions comprising at least one Fused Bicyclic Pyrazole Derivative, and methods of using the Fused Bicyclic Pyrazole Derivatives for treating or preventing a herpesvirus infection in a patient.
    Type: Application
    Filed: December 14, 2021
    Publication date: February 22, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Ronald K. Chang, Andrew J. Cooke, JR., Christopher Douglas Cox, Marc Labroli, Izzat Tiedje Raheem, Jack D. Scott, Jeffrey W. Schubert, Jason W. Skudlarek, Zheng Tan, Ling Tong
  • Patent number: 11859245
    Abstract: A primer set for detecting telomerase activity, the primer set including a first primer set or a second primer set. The first primer set includes: an upstream primer selected from MTS; and a downstream primer selected from the group consisting of ACX-M4, Beacon ACX62-2C, and Beacon ACX62-10. The second primer set includes: an upstream primer selected from STS or CTS; and a downstream primer selected from the group consisting of ACX, CXT, ACX-M4, Beacon ACX62-2C, or Beacon ACX62-10. The sequences of the primers ACX, CXT, ACX-M4, Beacon ACX62-2C, Beacon ACX62-10, STS, CTS and MTS are shown as SEQ ID NOs: 1 to 8, respectively.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: January 2, 2024
    Assignee: INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Zheng Tan, Kewei Zheng, Yuhua Hao
  • Publication number: 20230301336
    Abstract: Provided is a co-attrited MCC/CMC stabilizer composition containing MCC made from non-dissolving cellulose pulps that is useful for stabilizing plant protein based drinks. Also provided are plant protein drink compositions stabilized using the co-attrited MCC/CMC stabilizer composition containing MCC made from non-dissolving cellulose pulps. Also provided are methods of stabilizing plant protein drink compositions using the co-attrited MCC/CMC stabilizer composition containing MCC made from non-dissolving cellulose pulps.
    Type: Application
    Filed: December 6, 2022
    Publication date: September 28, 2023
    Inventors: Thomas Ruszkay, ZHENG TAN, Maurice Gerard Lynch, Albert Tsai, Joyce Mei Yan Toh, Parminder Agarwal
  • Patent number: 11767343
    Abstract: A polypeptide probe for detecting G-quadruplexes (G4s), includes: from two to four G4-binding domains, and one or more linkers disposed between every two G4-binding domains. Each G4-binding domain includes a specific motif including a sequence of amino acids PGHLKGREIGMWY (SEQ ID NO: 1).
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: September 26, 2023
    Assignee: CHANGZHI MEDICAL COLLEGE
    Inventors: Zheng Tan, Kewei Zheng, Jinping Zheng
  • Patent number: 11752128
    Abstract: Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a ?-lactam antibiotic.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: September 12, 2023
    Assignee: MERCK SHARP & DOHME CORPORATION
    Inventors: John P. Caldwell, Ginny Dai Ho, Sookhee N. Ha, Sandra J. Koseoglu, Marc A. Labroli, Sang Ho Lee, Christina Madsen-Duggan, Mihir Mandal, Jianping Pan, Weidong Pan, Terry Roemer, Jing Su, Christopher Michael Tan, Zheng Tan, Hao Wang, Christine Yang, Shu-Wei Yang
  • Patent number: 11738010
    Abstract: Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a ?-lactam antibiotic.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: August 29, 2023
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: John P. Caldwell, Reynalda De Jesus, Fa-Xiang Ding, Charles J. Gill, Ginny Dai Ho, Sookhee N. Ha, Sandra J. Koseoglu, Marc A. Labroli, Sang Ho Lee, Christina Madsen-Duggan, Mihir Mandal, Terry Roemer, Jing Su, Christopher Michael Tan, Zheng Tan, Haifeng Tang, Hao Wang, Christine Yang, Shu-Wei Yang
  • Publication number: 20230182807
    Abstract: Methods, apparatus, systems and articles of manufacture are disclosed. An example vehicle disclosed herein includes a steering assist system, a steering wheel, and a steering controller to detect a request to move the steering wheel of the vehicle to a first rotational position, the steering wheel having a second rotational position, actuate, via the steering assist system, the steering wheel towards the first rotational position, determine, based on a relationship between a first parameter and a second parameter, a third rotational position, the third rotational position having an angular offset from the first rotational position, the first parameter corresponding to a position of the steering system, the second parameter corresponding to a load on the steering system, and in response to reaching the third rotational position, disengage the steering assist system, the disengagement causing the steering wheel to rotate to the first rotational position.
    Type: Application
    Filed: December 9, 2021
    Publication date: June 15, 2023
    Inventors: Zhongzhou Yang, Alex Parker, Zheng Tan, Bo Lin, Justin Sekula, William Bouse
  • Publication number: 20230147170
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.
    Type: Application
    Filed: March 26, 2021
    Publication date: May 11, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Jacqueline D. Hicks, Amjad Ali, John S. Debenham, Anthony Donofrio, Wenlang Fu, Ying-Duo Gao, Alan Hruza, Yeon-Hee Lim, Matthew J. Lombardo, Peter Nizner, Sung-Sau So, Zheng Tan, Daniel A. Tatosian, Dong Xiao, Dexi Yang, Yang Yu
  • Patent number: 11602153
    Abstract: This invention relates to making and using a stabilizer that is effective in small amounts and, particularly useful for stabilizing low solids liquids, e.g., dispersions, emulsions, and suspensions, used in foods, pharmaceuticals, nutraceuticals, and similar industrial applications, which comprises, microcrystalline cellulose, (preferably, colloidal hydrolyzed MCC); a first carboxymethyl cellulose having a viscosity of 30-85 cP at 2% in deionized water; and, a degree of carboxymethyl substitutions of 0.60 to 0.85, and a second carboxymethyl cellulose having a viscosity of 400-800 cP at 2% in deionized water, and a degree of carboxymethyl substitutions of 0.80 to 0.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: March 14, 2023
    Assignee: DUPONT NUTRITION USA, INC.
    Inventors: Zheng Tan, Mei Yan Joyce Toh, Simon Patrick Charles Eustace, Jeremy Ondov
  • Publication number: 20220289270
    Abstract: Methods and apparatus are disclosed herein to center a steering wheel. An example vehicle includes a steering assistance system, an axle including a wheel, memory, and a processor to execute instructions to identify a first position of the wheel, detect a request to move the wheel to a second position, adjust the wheel from the first position to the second position via the steering assistance system, disengage the steering assistance system, the disengagement of the steering assistance system to cause the wheel to move to a third position, the third position offset from the second position by an angular offset in a first direction, adjust the wheel to a fourth position, the fourth position offset from the second position by the angular offset in a second direction different than the first direction, and disengage the steering assistance system, the disengagement of the steering assistance system to cause the wheel to move to the second position..
    Type: Application
    Filed: May 2, 2022
    Publication date: September 15, 2022
    Inventors: Daniel James Nichols, William James Bouse, Justin Sekula, Alex Parker, Zhongzhou Yang, Timothy Panagis, Zheng Tan, Bo Lin
  • Patent number: 11286621
    Abstract: Embodiments disclosed herein provide enzymatic formulations comprising a polypeptide having amylase activity for producing a paper product. Also provided are aqueous surface treatment compositions for paper and board comprising degraded starch. Further provided are methods for producing paper and board using the aqueous surface treatment composition, and to corrugated boards produced from this paper.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: March 29, 2022
    Assignee: BASF SE
    Inventors: Christoph Hamers, Konstantino Karanikas, Kenneth Barrett, Zheng Tan
  • Publication number: 20210403507
    Abstract: A polypeptide probe, including: from two to four G4-binding domains, and one or more linkers disposed between every two G4-binding domains. Each G4-binding domain includes a specific motif including a sequence of amino acids (SEQ?ID?NO:?1) PGHLKGREIGMWY.
    Type: Application
    Filed: June 8, 2020
    Publication date: December 30, 2021
    Inventors: Zheng TAN, Kewei ZHENG, Jinping ZHENG
  • Publication number: 20210346364
    Abstract: Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a ?-lactam antibiotic.
    Type: Application
    Filed: July 26, 2021
    Publication date: November 11, 2021
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: John P. CALDWELL, Reynalda DE JESUS, Fa-Xiang DING, Charles J. GIll, Ginny Dai HO, Sookhee N. HA, Sandra J. KOSEOGLU, Marc A. LABROLI, Sang Ho LEE, Christina MADSEN-DUGGAN, Mihir MANDAL, Terry ROEMER, Jing SU, Christopher Michael TAN, Zheng TAN, Haifeng TANG, Hao WANG, Christine YANG, Shu-Wei YANG
  • Publication number: 20210346344
    Abstract: Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a ?-lactam antibiotic.
    Type: Application
    Filed: July 26, 2021
    Publication date: November 11, 2021
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: John P. CALDWELL, Ginny Dai HO, Sookhee N. HA, Sandra J. KOSEOGLU, Marc A. LABROLI, Sang Ho LEE, Christina MADSEN-DUGGAN, Mihir MANDAL, Jianping PAN, Weidong PAN, Terry ROEMER, Jing SU, Christopher Michael TAN, Zheng TAN, Hao WANG, Christine YANG, Shu-Wei YANG
  • Patent number: 11141410
    Abstract: Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a ?-lactam antibiotic.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: October 12, 2021
    Assignee: MERCK SHARP & DOHME CORP
    Inventors: John P. Caldwell, Reynalda De Jesus, Fa-Xiang Ding, Charles J. Gill, Ginny Dai Ho, Sookhee N. Ha, Sandra J. Koseoglu, Marc A. Labroli, Sang Ho Lee, Christina Madsen-Duggan, Mihir Mandal, Terry Roemer, Jing Su, Christopher Michael Tan, Zheng Tan, Haifeng Tang, Hao Wang, Christine Yang, Shu-Wei Yang
  • Patent number: 11141403
    Abstract: Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a ?-lactam antibiotic.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: October 12, 2021
    Assignee: MERCK SHARP & DOHME CORP
    Inventors: John P. Caldwell, Ginny Dai Ho, Sookhee N. Ha, Sandra J. Koseoglu, Marc A. Labroli, Sang Ho Lee, Christina Madsen-Duggan, Mihir Mandal, Jianping Pan, Weidong Pan, Terry Roemer, Jing Su, Christopher Michael Tan, Zheng Tan, Hao Wang, Christine Yang, Shu-Wei Yang
  • Publication number: 20210262165
    Abstract: A process comprising treating a lignocellulosic material preferably pulp in the presence of a transition metal catalyst with a oxidizing agent selected from a group consisting of hydrogen peroxide, hypochlorite, hypochlorous acid and any combination thereof to form a treated lignocellulosic material having a viscosity equal to or less than about 17 cp and having reducing functional groups selected from the group consisting of aldehyde and aldehyde type functional groups at the C6 and C1 positions but predominating at the C1 position.
    Type: Application
    Filed: December 23, 2020
    Publication date: August 26, 2021
    Inventors: Zheng Tan, Damaris Lorenzoni, Gopal Goyal, Sen Yang
  • Publication number: 20210198716
    Abstract: A primer set for detecting telomerase activity, the primer set including a first primer set or a second primer set. The first primer set includes: an upstream primer selected from MTS; and a downstream primer selected from the group consisting of ACX-M4, Beacon ACX62-2C, and Beacon ACX62-10. The second primer set includes: an upstream primer selected from STS or CTS; and a downstream primer selected from the group consisting of ACX, CXT, ACX-M4, Beacon ACX62-2C, or Beacon ACX62-10. The sequences of the primers ACX, CXT, ACX-M4, Beacon ACX62-2C, Beacon ACX62-10, STS, CTS and MTS are shown as SEQ ID NOs: 1 to 8, respectively.
    Type: Application
    Filed: July 27, 2020
    Publication date: July 1, 2021
    Inventors: Zheng TAN, Kewei ZHENG, Yuhua HAO
  • Patent number: 10907304
    Abstract: A process comprising treating a lignocellulosic material preferably pulp in the presence of a transition metal catalyst with a oxidizing agent selected from a group consisting of hydrogen peroxide, hypochlorite, hypochlorous acid and any combination thereof to form a treated lignocellulosic material having a viscosity equal to or less than about 17 cp and having reducing functional groups selected from the group consisting of aldehyde and aldehyde type functional groups at the C6 and C1 positions but predominating at the C1 position.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: February 2, 2021
    Assignee: INTERNATIONAL PAPER COMPANY
    Inventors: Zheng Tan, Damaris Lorenzoni, Gopal Goyal, Sen Yang
  • Patent number: 10798427
    Abstract: The present invention relates to a system and method for providing a failover of storage for media content, including media content used for broadcasting in cinema. One embodiment of the invention stores copies of digital cinema packages (“DCPs”) to both a central storage facility as well as a local storage facility. When a server module reading DCPs in central storage module encounters abnormalities, it switches reading operations to the local storage module, at the same frame location from which interruption occurred. The present invention provides a multi-layered storage system for cinema broadcasting of a movie to decrease likelihood of interruptions during a broadcast that may be caused by failure of the central storage facility.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: October 6, 2020
    Assignee: GDC TECHNOLOGY (SHENZHEN) LIMITED
    Inventors: Man Nang Chong, Pranay Kumar, Chern Yue Kwok, Jing Zheng Tan, Jian Xing Huang