Patents by Inventor Zheng Xin Dong

Zheng Xin Dong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANALOGUES OF EXENDIN-4 AND EXENDIN-3
    Publication number: 20100256056
    Abstract: The present invention is directed to peptide analogues of Exendin-3 and Exendin-4 and pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions containing said analogues and/or pharmaceutically-acceptable salts thereof.
    Type: Application
    Filed: September 5, 2008
    Publication date: October 7, 2010
    Inventor: Zheng Xin Dong
  • METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS
    Publication number: 20100234564
    Abstract: The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal N-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a ?-(methylamino)-thioester intermediate that spontaneously rearranges to form an amide bond. Furthermore, the invention relates to methods of converting N-methyl-thiazolidine to N-methyl-cysteine (SEQ ID NO: 1) of polypeptides and proteins. The invention also relates to methods of synthesizing peptide-thioester from peptide-acid fluoride.
    Type: Application
    Filed: August 27, 2008
    Publication date: September 16, 2010
    Inventors: Zheng Xin Dong, John S. Eynon
  • METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS
    Publication number: 20100204449
    Abstract: The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal ?-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a ?-amino-thioester intermediate that spontaneously rearranges to form an amide bond. The invention also relates to methods of synthesizing ?-methyl-cysteine (SEQ ID NO: 1) and its protected forms. Furthermore, the invention relates to converting a ?-methyl-thiazolidine residue to a ?-methyl-cysteine (SEQ ID NO: 1) residue of polypeptides and proteins.
    Type: Application
    Filed: August 28, 2008
    Publication date: August 12, 2010
    Inventors: Zheng Xin Dong, Sun H. Kim
  • MELANOCORTIN RECEPTOR LIGANDS MODIFIED WITH HYDANTOIN
    Publication number: 20100184646
    Abstract: The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction.
    Type: Application
    Filed: May 23, 2008
    Publication date: July 22, 2010
    Inventors: Zheng Xin Dong, Daniel B. Deoliveira, Jeanne Mary Comstock
  • Somatostatin-Dopamine Chimeric analogs
    Publication number: 20100179304
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo.
    Type: Application
    Filed: October 7, 2009
    Publication date: July 15, 2010
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • CYCLIC PEPTIDE MELANOCORTIN RECEPTOR LIGANDS
    Publication number: 20100173834
    Abstract: The present invention is directed to compounds according to formula, (R2R3)-A0A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1, wherein the definitions of A1 to A10 and R1 to R3 are provided in the application, and pharmaceutically-acceptable salts thereof, that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals, and to pharmaceutical compositions comprising said compounds.
    Type: Application
    Filed: June 13, 2008
    Publication date: July 8, 2010
    Inventor: Zheng Xin Dong
  • GLP-1 PHARMACEUTICAL COMPOSITIONS
    Publication number: 20100137204
    Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues.
    Type: Application
    Filed: December 31, 2007
    Publication date: June 3, 2010
    Inventors: Zheng Xin Dong, Roland Cherif-Cheikh, Jose-Antonio Cordero-Rigol, Resurreccion Alloza Miravete, Frederic Lacombe, Maria Dolores Tobalina Maestre
  • PEPTIDE-CYTOTOXIC CONJUGATES
    Publication number: 20100113367
    Abstract: The invention features targeted cytotoxic compounds and methods relating to their therapeutic use for the treatment of neoplasia and other conditions.
    Type: Application
    Filed: October 17, 2007
    Publication date: May 6, 2010
    Inventors: Zheng Xin Dong, Yeelana Shen, Michael DeWitt Culler, Christophe Alain Thurieau, Jundong Zhang, Sun Hyuk Kim
  • Pharmaceutical Compositions of Hglp-1, Exendin-4 and Analogs Thereof
    Publication number: 20100087365
    Abstract: The present invention is directed to pharmaceutical composition comprising a clear solution or an aqueous mixture, a suspension or a semisolid of at least one peptide compound selected from the group consisting of hGLP-1(7-36)-NH2 and analogs and derivatives thereof, hGLP-1(7-37)-OH and analogs and derivatives thereof and/or exendin-4 and analogs and derivatives thereof, zinc and solvent wherein at least 95% of the said peptide compound is dissolved by the solvent.
    Type: Application
    Filed: April 13, 2007
    Publication date: April 8, 2010
    Inventors: Roland Cherif-Cheikh, Zheng Xin Dong, Maria Dolores Tobalina Maestre, Jose-Antonio Cordero-Rigol, Frederic Lacombe
  • Ghrelin analogs
    Publication number: 20100069299
    Abstract: The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof.
    Type: Application
    Filed: June 16, 2009
    Publication date: March 18, 2010
    Inventors: Zheng Xin Dong, Yeelana Shen
  • Methods for Site-Specific Pegylation
    Publication number: 20100016550
    Abstract: The present invention relates to methods for the chemo-selective pegylation of the cysteine residue having unoxidized sulfhydryl side-chain and free ?-amino group in proteins, peptides and other molecules. Similar methods are provided for the chemo-selective pegylation of the homocysteine, selenocysteine, penicillamine, and N-methyl-cysteine residues.
    Type: Application
    Filed: May 25, 2007
    Publication date: January 21, 2010
    Inventors: Zheng Xin Dong, John S. Eynon
  • Analogs of parathyroid hormone
    Patent number: 7632811
    Abstract: The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pharmaceutical compositions comprising said analogues alone or in combination with a bisphosphonate or calcitonin.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: December 15, 2009
    Assignee: Societe de Conseils de Recherches et D'Applications Scientifiques, SAS
    Inventor: Zheng Xin Dong
  • Compositions and Methods for Stimulating Gastrointestinal Motility
    Publication number: 20090304724
    Abstract: The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient.
    Type: Application
    Filed: September 28, 2006
    Publication date: December 10, 2009
    Inventors: Rakesh Datta, Zheng Xin Dong
  • Somatostatin-dopamine chimeric analogs
    Publication number: 20090275501
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo.
    Type: Application
    Filed: June 22, 2009
    Publication date: November 5, 2009
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • ANALOGS OF GHRELIN SUBSTITUTED AT THE N-TERMINAL
    Publication number: 20090275511
    Abstract: The invention comprises peptidyl analogs of ghrelin having greater stability which are active at the GHS receptor according to formulae depicted below: (R2)-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-R1 wherein the definitions of A1 to A28, R1 and R2 are provided for in the specification, with the exception that the N-terminal amino acid must be selected from the group consisting of Inp, 1-Apc and 4-Apc, the pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising an effective amount of said compound together with therapeutic and non-therapeutic uses thereof.
    Type: Application
    Filed: September 24, 2007
    Publication date: November 5, 2009
    Inventor: Zheng Xin Dong
  • Ligands of melanocortin receptors
    Publication number: 20090232838
    Abstract: The present invention is directed to a compound according to formula, (R2R3)-B1-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-A11-A12-A13-B2-B3-R1, that act as ligands for one or more of the melanocortin receptors, the pharmaceutically-acceptable salts thereof, to methods of using such peptides to treat mammals and to pharmaceutical compositions useful therefore comprising said peptides.
    Type: Application
    Filed: July 10, 2006
    Publication date: September 17, 2009
    Inventors: Zheng Xin Dong, Jacques-Pierre Moreau
  • Ghrelin analogs
    Patent number: 7589058
    Abstract: The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: September 15, 2009
    Assignee: Ipsen Pharma, S.A.S.
    Inventors: Zheng Xin Dong, Yeelena Shen
  • PTH2 RECEPTOR SELECTIVE COMPOUNDS
    Publication number: 20090226477
    Abstract: This invention relates to a series of PTH and PTHrP analogues that selectively bind to PTH2 receptors and as such may be useful in treating abnormal CNS functions; abnormal pancreatic functions; divergence from normal mineral metabolism and homeostasis; male infertility; regulation of abnormal blood pressure; and hypothalmic disease.
    Type: Application
    Filed: March 27, 2009
    Publication date: September 10, 2009
    Inventors: Zheng Xin Dong, Michael Chorev, Michael Rosenblatt
  • Somatostatin-dopamine chimeric analogs
    Patent number: 7579435
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8?-ergolinglmethylthioacetyl-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: August 25, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Somatostatin-dopamine chimeric analogs
    Patent number: 7572883
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: August 11, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau