Patents by Inventor Zheng Ye

Zheng Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9126136
    Abstract: Cassette bodies for use with electrophoresis apparatus can be formed of a single piece of molded or machined plastic. Such cassette bodies can include a plurality of channels that pass through the cassette body, from a proximal end to a distal end. Such channels can be defined by upper and lower chambers. The upper chambers can be in fluid communication with a first buffer pool through a semi-permeable membrane, and the lower chambers can be in fluid communication with a second buffer pool. An electric current can be passed through the first and second buffer pools, and then reversed, to perform an electrophoresis operation that can separate a biomolecule of interest from free probes, and provide for convenient collection of said biomolecule of interest.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: September 8, 2015
    Assignee: Oregon Health & Science University
    Inventors: Zheng Ye, William D. Mathers, Ed Brightman
  • Publication number: 20150065378
    Abstract: Synthetic oligonucleotides that comprise a nucleic acid binding protein binding site, PCR primer sequences, and tag sequences that do not bind to nucleic acid binding proteins, with a total length of 85-130 nucleotides are disclosed herein. Also disclosed are libraries and kits comprising the synthetic oligonucleotides as well as methods of detecting nucleic acid binding proteins in a sample using the synthetic oligonucleotides.
    Type: Application
    Filed: August 28, 2014
    Publication date: March 5, 2015
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: William Mathers, Zheng Ye
  • Publication number: 20130288483
    Abstract: A dynamically tunable process kit, a processing chamber having a dynamically tunable process kit, and a method for processing a substrate using a dynamically tunable process kit are provided. The dynamically tunable process kit allows one or both of the electrical and thermal state of the process kit to be changed without changing the phyisical construction of the process kit, thereby allowing plasma properties, and hence processing results, to be easily changed without replacing the process kit. The processing chamber having a dynamically tunable process kit includes a chamber body that includes a portion of a conductive side wall configured to be electrically controlled, and a process kit. The processing chamber includes a first control system operable to control one or both of an electrical and thermal state of the process kit and a second control system operable to control an electrical state of the portion of the side wall.
    Type: Application
    Filed: February 13, 2013
    Publication date: October 31, 2013
    Inventors: S.M. Reza Sadjadi, Dmitry Lubomirsky, Hamid Noorbakhsh, John Zheng Ye, David H. Quach, Sean S. Kang
  • Publication number: 20130284599
    Abstract: Cassette bodies for use with electrophoresis apparatus can be formed of a single piece of molded or machined plastic. Such cassette bodies can include a plurality of channels that pass through the cassette body, from a proximal end to a distal end. Such channels can be defined by upper and lower chambers. The upper chambers can be in fluid communication with a first buffer pool through a semi-permeable membrane, and the lower chambers can be in fluid communication with a second buffer pool. An electric current can be passed through the first and second buffer pools, and then reversed, to perform an electrophoresis operation that can separate a biomolecule of interest from free probes, and provide for convenient collection of said biomolecule of interest.
    Type: Application
    Filed: June 26, 2013
    Publication date: October 31, 2013
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Zheng Ye, William D. Mathers, Ed Brightman
  • Patent number: 8496798
    Abstract: Cassette bodies for use with electrophoresis apparatus can be formed of a single piece of molded or machined plastic. Such cassette bodies can include a plurality of channels that pass through the cassette body, from a proximal end to a distal end. Such channels can be defined by upper and lower chambers. The upper chambers can be in fluid communication with a first buffer pool through a semi-permeable membrane, and the lower chambers can be in fluid communication with a second buffer pool. An electric current can be passed through the first and second buffer pools, and then reversed, to perform an electrophoresis operation that can separate a biomolecule of interest from free probes, and provide for convenient collection of said biomolecule of interest.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: July 30, 2013
    Assignee: Oregon Health & Science University
    Inventors: Zheng Ye, William Mathers, Ed Brightman
  • Publication number: 20120160683
    Abstract: Cassette bodies for use with electrophoresis apparatus can be formed of a single piece of molded or machined plastic. Such cassette bodies can include a plurality of channels that pass through the cassette body, from a proximal end to a distal end. Such channels can be defined by upper and lower chambers. The upper chambers can be in fluid communication with a first buffer pool through a semi-permeable membrane, and the lower chambers can be in fluid communication with a second buffer pool. An electric current can be passed through the first and second buffer pools, and then reversed, to perform an electrophoresis operation that can separate a biomolecule of interest from free probes, and provide for convenient collection of said biomolecule of interest.
    Type: Application
    Filed: September 1, 2010
    Publication date: June 28, 2012
    Inventors: Zheng Ye, William Mathers, Ed Brightman
  • Publication number: 20110011742
    Abstract: Disclosed are methods and devices for electrophoretic separation of free biomolecules from molecular complexes comprising biomolecules of interest during which inhomogeneity in the molecular complexes is masked. The methods can include loading a sample which contains free biomolecules and the complexes that include biomolecules of interest to a proximal end of an electrophoresis gel. The sample is electrophoresed for a period of time sufficient for the free biomolecules to elute off a distal end of the gel while the molecular complexes that include the biomolecules of interest are retained in the electrophoresis gel, thereby separating the molecular complexes from the free biomolecules. The direction of electrophoresis is reversed and the sample is electrophoresed for a period of time sufficient for the molecular complexes of bound biomolecules of interest to elute from the proximal end of the electrophoresis gel.
    Type: Application
    Filed: March 2, 2009
    Publication date: January 20, 2011
    Inventors: William D. Mathers, Zheng Ye
  • Publication number: 20100184614
    Abstract: Disclosed are methods for identifying double-stranded nucleic acid protein binding sites and double-stranded nucleic acid binding proteins. The method can include contacting a sample with at least one partially double-stranded nucleic acid probe under conditions that permit binding of double-stranded binding proteins and partially double-stranded nucleic acid probes. In particular examples, the partially double-stranded nucleic acid probes include a first portion of single-stranded nucleic acid at least about 15 nucleotides in length with a unique index sequence and a second portion of double-stranded nucleic acid greater than about 8 base pairs in length with a potential binding site for a double-stranded nucleic acid binding protein. The protein bound partially double-stranded nucleic acid probe can then be isolated and detected by hybridization to a nucleic acid indexing probe. Also disclosed are kits and devices for carrying out the methods.
    Type: Application
    Filed: May 22, 2008
    Publication date: July 22, 2010
    Inventors: Zheng Ye, William Mathers
  • Patent number: 7701230
    Abstract: One embodiment of the invention relates to an apparatus for profiling an ion beam. The apparatus includes a current measuring device having a measurement region, wherein a cross-sectional area of the ion beam enters the measurement region. The apparatus also includes a controller configured to periodically take beam current measurements of the ion beam and to determine a two dimensional profile of the ion beam by relating the beam current measurements to sub-regions within the current measuring device. Other apparatus and methods are also disclosed.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: April 20, 2010
    Assignee: Axcelis Technologies, Inc.
    Inventors: John Zheng Ye, Michael Paul Cristoforo, Yongzhang Huang, Michael A. Graf, Bo H. Vanderberg
  • Publication number: 20080265866
    Abstract: One embodiment of the invention relates to an apparatus for profiling an ion beam. The apparatus includes a current measuring device having a measurement region, wherein a cross-sectional area of the ion beam enters the measurement region. The apparatus also includes a controller configured to periodically take beam current measurements of the ion beam and to determine a two dimensional profile of the ion beam by relating the beam current measurements to sub-regions within the current measuring device. Other apparatus and methods are also disclosed.
    Type: Application
    Filed: April 30, 2007
    Publication date: October 30, 2008
    Inventors: John Zheng Ye, Michael Paul Cristoforo, Yongzhang Huang, Michael A. Graf, Bo H. Vanderberg
  • Patent number: 6703628
    Abstract: Ion implantation systems and beamline assemblies therefor are provided, in which multi-cusped magnetic fields are provided in a beamguide and the beamguide is energized to provide microwave electric fields in a traveling wave along the beamguide passageway. The magnetic and electric fields interact to provide an electron-cyclotron resonance condition for beam containment in the beamguide passageway.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: March 9, 2004
    Assignee: Axceliss Technologies, Inc
    Inventors: John Zheng Ye, Victor M. Benveniste, Michael Paul Cristoforo
  • Publication number: 20030201402
    Abstract: Ion implantation systems and beamline assemblies therefor are provided, in which multi-cusped magnetic fields are provided in a beamguide and the beamguide is energized to provide microwave electric fields in a traveling wave along the beamguide passageway. The magnetic and electric fields interact to provide an electron-cyclotron resonance condition for beam containment in the beamguide passageway.
    Type: Application
    Filed: May 23, 2003
    Publication date: October 30, 2003
    Inventors: John Zheng Ye, Victor M. Benveniste, Michael Paul Cristoforo
  • Publication number: 20020004592
    Abstract: Applicants have identified a novel amplification method that uses two specific primers to clone both the 5′ and 3′ cDNA ends in a single reaction. This new method also uses the first strand of cDNA obtained after reverse transcription of mRNA rather than double stranded cDNA, further increasing efficiency of amplification. According to the invention the first strand of cDNA is self-ligated using a DNA ligase.
    Type: Application
    Filed: February 9, 2001
    Publication date: January 10, 2002
    Inventors: James R. Connor, Zheng Ye