Abstract: Provided are a viral vector-based RNA delivery system and a use thereof. The RNA delivery system comprises a viral vector. The viral vector carries an RNA fragment needing to be delivered, and can be enriched in organ tissues of a host. In the host organ tissues, the viral vector can endogenously and spontaneously form a composite structure containing the RNA fragment. The composite structure can enter and bind to target tissues, and feed the RNA fragment into the target tissues. The viral vector has a targeting tag. The composite structure is an exosome. The viral vector RNA delivery system is safe and reliable, and has good druggability and high universality.

Abstract: Provided are a gene circuit, an RNA delivery system and the use thereof. Specifically, the gene circuit comprises at least an RNA fragment capable of inhibiting gene expression and/or a targeting tag having a targeting function. The gene circuit can be delivered to a host, enriched in organ tissues of the host and self-assembled to form a complex structure, and inhibits gene expression by means of the RNA fragment, thereby treating diseases. The delivery system comprises the gene circuit and a delivery carrier capable of delivering the gene circuit to organ tissues of a host for enrichment. The provided gene circuit has a targeting function and a treatment function, can quickly and accurately reach target organs and target tissues to exert a treatment effect, and is highly efficient with good results. The safety and reliability of the provided RNA delivery system are fully verified, and the RNA delivery system has good druggability, high universality, and great economic benefits and application prospects.

Abstract: Provided are an RNA plasmid delivery system and an application thereof. The RNA plasmid delivery system comprises a plasmid carrying an RNA fragment required to be delivered; the plasmid can be enriched in an organ tissue of a host, and spontaneously forms an exosome containing the RNA fragment in the organ tissue of the host, and therefore can enter and be combined with a target tissue to deliver the RNA fragment into the target tissue. The RNA delivery system is safe, reliable, good in druggability, and strong in universality.

Abstract: An RNA delivery system for the treatment of Huntington's disease. The system comprises a viral vector, the viral vector carries RNA fragments capable of treating Huntington's disease, the viral vector is capable of enrichment in organ tissues of a host and endogenously and spontaneously forming a complex containing the RNA fragments capable of treating Huntington's disease in the organ tissues of the host, and the complex can deliver the RNA fragments into a target tissue to treat Huntington's disease. The safety and reliability of the RNA delivery system for the treatment of Huntington's disease have been fully verified. The system has good medicinal properties, strong versatility, and has economic benefits and application prospects.

Abstract: Embodiments of the present disclosure generally relate to methods and apparatus for measuring and controlling local impedances at a substrate support in a plasma processing chamber during processing of a substrate. A substrate support includes a plurality of substrate support pins wherein the radio frequency voltage, current and phase of each of the plurality of substrate support pins are measured and impedances of the support pins are adjusted in real time. Each of the substrate support pins is coupled to an associated adjustable impedance circuit that may be remotely controlled. In one embodiment a variable capacitor is used to adjust the impedance of the impedance circuit coupled to the associated substrate support pin and may be remotely adjusted with a stepper motor.

Abstract: Compositions for regeneration of inner cells and for treating hearing loss comprise at least one modulator of mechanistic target of rapamycin (mTOR) sufficient to induce reprogramming proliferation and regeneration of inner ear cells. The composition include, in some instances, an effective amount of one or more phosphatase and tensin homolog (PTEN) inhibitors, MYC/NOTCH modulators, Atonal Homolog 1 (Atoh1) modulators or combinations thereof.

Abstract: The invention provides 3D-knitted spacer fabrics of high breathability and moisture management and methods of making the 3D-knitted spacer fabrics. The middle layer of the fabric is made of hydrophilic material, comprising two yarns, a blended thermo-fuse wicking yarn comprising hydrophilic fiber and thermo-fuse fiber, and a non-supportive hydrophilic functional wicking yarn. The top layer of the fabric comprises a hydrophilic yarn, and the third layer of the fabric comprises a hydrophobic yarn. The 3D-knitted spacer fabrics are useful in clothing and equipment for wear in high temperature environments.

Abstract: An interaction method and apparatus and an electronic device. The method comprises: displaying a first application interface, wherein the first application interface comprises an interface of a first application; and creating a second application account in the first application interface, wherein the second application account is used for logging in a second application. Therefore, a new interaction mode is provided.

Abstract: An experimental device and method for supercritical CO2/H2O mixed fluid huff and puff for shale oil development includes a CO2 storage tank, a water vapor generator, a mixing vessel, and a core holder; the CO2 storage tank and the water vapor generator are in communication with the mixing vessel; a first pressure gauge and a hygronom are connected to an upper end of the mixing vessel, and a displacement pump is connected to a lower end of the mixing vessel; the mixing vessel is connected to an inlet end of the core holder; the core holder is connected to an inlet end of a drying pipe, and the measuring cylinder is disposed upside down in a liquid containing dish, where the liquid containing dish and the measuring cylinder are filled with a saturated sodium carbonate solution.

Abstract: Techniques for using transfer learning to address label data shortage in seniority modeling for an online service are disclosed herein. In some embodiments, a computer-implemented method comprises training an initialized neural network using training examples comprising profile data and labels for the profile data, where each label comprises a standardized position title, and the training of the initialized neural network forms a pre-trained neural network. Next, the computer system may train the pre-trained neural network using training examples comprising profile data and labels for the profile data, where the labels comprise a position seniority, and the training of the pre-trained neural network forms a fine-tuned neural network. The computer system may then compute the position seniority for a user based on profile data of the user using the fine-tuned neural network, and use the position seniority of the user in an application of an online service.

Abstract: Embodiments of this application disclose a request processing method and a corresponding entity, to control a data notification and signaling that is used for triggering paging, thereby avoiding overload of a network element in a core network. The request processing method includes: determining, by an AMF, a first control plane function entity for a terminal device; determining, by the AMF, that the terminal device enters an idle state; obtaining, by the AMF, a first reachability service invocation request from the first control plane function entity; and rejecting, by the AMF, the first reachability service invocation request when the AMF determines, based on the first reachability service invocation request, that a reachability service invocation limitation condition is satisfied.

Abstract: A display module structure and a display device are provided. The display module structure includes a support plate and a frame. The support plate includes a first interference member disposed on an interference surface and a support surface configured for disposition of an optical assembly. The support surface is located at a vertical level higher than a vertical level of the first interference member. The first interference portion and the first interference member are fastened with each other to fix the frame to the support plate, so that a width of a side portion of the display module structure can be reduced.

Abstract: An information handling system may include at least one processor; and a non-transitory memory coupled to the at least one processor. The information handling system may be a node of an information handling system cluster may be configured to be imaged while the node is operational within the information handling system cluster by: a node installation service executing on the node creating a partition on a storage medium of the node; the node installation service receiving an image bundle from a remote information handling system via a network and storing the image bundle on the partition; and the node installation service causing the node to reboot, wherein the rebooting is configured to install a new version of a management system to the node from the image bundle.

Abstract: A displaying base plate and a manufacturing method thereof, and a displaying device. The displaying base plate includes a substrate, and a first electrode layer disposed on one side of the substrate, wherein the first electrode layer includes a first electrode pattern; a first planarization layer disposed on one side of the first electrode layer that is away from the substrate, wherein the first planarization layer is provided with a through hole, and the through hole penetrates the first planarization layer, to expose the first electrode pattern; and a second electrode layer, a second planarization layer and a third electrode layer that are disposed in stack on one side of the first planarization layer that is away from the substrate, wherein the second electrode layer is disposed closer to the substrate, the second electrode layer is connected to the first electrode pattern and the third electrode layer.

Abstract: Provided herein are methods for regenerating hair cells in an adult mammalian inner ear using novel combinations of agents selected from the group consisting of a histone deacetylase (HDAC) inhibitor, one or more inhibitory nucleic acids targeting Fir, Mxi1, Fbxw7, or a combination thereof, a Wnt pathway activator, and a cAMP activator. The methods and compositions can be used to treat a subject with hearing loss or vestibular dysfunction.

Abstract: The present disclosure provides an arctigenin liquid nano-preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparation. In the present disclosure, arctigenin is prepared into a liquid nano-preparation, having advantages of distribution of a droplet diameter on nanoscale, significantly increased specific surface area, rapid absorption, and high bioavailability. Meanwhile, nano-preparation entered the body can be captured by wandering leucocytes, and a medicament is delivered to inflammatory lesions through chemiotaxis, thereby conferring a targeted drug delivery feature on the arctigenin and making a therapy more targeted. Moreover, in the present disclosure, the arctigenin is dissolved in an oil phase, and the oil phase is dissolved in water by emulsification to further make the arctigenin dissolve in the water and increase water solubility of the arctigenin.

Abstract: An ear cartilage tissue engineering complex and a preparation method therefor are provided. The complex includes an ear cartilage gel or ear cartilage patch particles containing ear cartilage cells, and a porous frame structure. The ear cartilage gel or ear cartilage patch particles are inoculated onto the porous frame structure to form an ear cartilage gel/ear cartilage patch particle-frame structure complex. The ear cartilage tissue engineering complex is used for the repair and reconstruction of articular cartilage.

Abstract: A cartilage tissue engineering complex, e.g., a graft, has a cartilage gel or perichondral particles containing chondrocytes as well as a porous frame structure. The cartilage gel or perichondral particles is/are loaded on the porous frame structure to form a cartilage gel/perichondral particle-frame structure complex. The method for preparing the cartilage tissue engineering graft and a use of said graft in repair and reconstruction of articular cartilage are also provided.