Abstract: A mechanical-electrical-hydraulic composite transmission device and a control method thereof are provided. The device includes an input shaft assembly, a power-split assembly, a hydraulic transmission assembly, an electrical variable transmission assembly, a mechanical transmission assembly, a power-convergence assembly, and an output shaft. Three types of transmission modes including single transmission modes, power-split composite transmission modes, and power-convergence composite transmission modes are implemented by controlling engagement and disengagement of clutches and a brake. Free switching between various transmission modes is realized, the requirements of engineering machinery for a transmission device with multiple modes in different working conditions are satisfied, the engine power utilization is improved, and the fuel economy is increased. The shift impact is effectively reduced and the speed ratio adjustment range is expanded.

Abstract: A control circuit and method for an isolated switching-mode converter are disclosed. A secondary side controller receives and responds to a sleep control signal to generate a sleep request signal. When the sleep control signal is in a first state, the secondary-side controller enters a sleep mode and switches the sleep request signal to a third state. A primary-side controller responds to the sleep request signal in the third state and enters the sleep mode. In this way, the primary-side controller can enter the sleep mode in response to the entry of the secondary-side controller into the sleep mode. After the primary and second controllers enter the sleep mode, a majority of functional modules therein, as well as a signal isolator between the controllers, are turned off, effectively reducing standby power consumption of the system.

Abstract: The present invention provides a control circuit of an isolated power supply and an isolated power supply. A secondary side controller in the control circuit can turn on and off a synchronous rectifier based on a voltage from a secondary side winding, enabling adaptive turn-on and turn-off control of the synchronous rectifier. Specifically, when the voltage from the secondary side winding reaches a second predetermined voltage, an instruction for turning off the synchronous rectifier is provided. The second predetermined voltage is adjusted based on a comparison between a time interval for the previous switching period and a predetermined reference interval. In this way, a delay from a turn-off time of the synchronous rectifier to a turn-on time of a primary transistor switch is substantially maintained at the predetermined reference interval. This prevents cross-conduction of the primary and secondary side circuits, ensuring safe operation of the isolated power supply.

Abstract: A control circuit and method for an isolated switching-mode converter are disclosed. In the control circuit, in preparation for turning on a primary transistor switch in a primary-side circuit, preferably, a secondary-side controller transmits an inquiry signal to a primary-side controller, and the primary-side controller transmits, after confirming that it has been prepared, a feedback signal to the secondary-side controller to allow the secondary-side controller to confirm that the primary transistor switch has been turned off. After that, the primary-side controller turns on the primary transistor. In other words, in the control circuit and method of the present invention, in preparation for turning on the primary transistor switch, information exchange is conducted between the primary and secondary sides to make sure that the primary transistor switch is turned on after the synchronous rectifier transistor is turned off.

Abstract: A control circuit and method for an isolated switching-mode converter are disclosed. In the control circuit, before preparing to turn on a primary transistor switch in a primary-side circuit, preferably, a secondary-side controller transmits an inquiry signal to a primary-side controller, and the primary-side controller transmits, after confirming that it has been prepared, a feedback signal to the secondary-side controller to allow the secondary-side controller to turn off a synchronous rectifier transistor based on the feedback signal. After that, the primary-side controller turns on the primary transistor. In other words, in the control circuit and method of the present invention, in preparation for turning on the primary transistor switch, information exchange is conducted between the primary and secondary sides to make sure that the primary transistor switch is turned on after the synchronous rectifier transistor is turn off.

Abstract: Provided are a mutant of an immunoglobulin degrading enzyme IdeE, a protein comprising the mutant, and a use of a composition and a kit in preparation of a drug for reducing the level of IgG in a subject. The mutant has amino acid substitution, N-terminal truncated and/or C-terminal truncated on one or more of positions 8, 10, 24, 59, 97, and 280 of the amino acid sequence shown in SEQ ID NO: 2, and the mutant has the function of the immunoglobulin degrading enzyme IdeE, and has higher activity and thermal stability than wild-type IdeE.

Abstract: The present application provides an isolated switched-mode power supply, a control method and a computer-readable storage medium. The isolated SMPS includes: primary side circuits each including a power switch; secondary side circuits each including a synchronous rectifier; at least two transformers each including a primary winding connected in series with power switch and a secondary winding connected in series with synchronous rectifier, the number of primary side circuits, the number of secondary side circuits and the number of transformers are equal to one another; an isolated controller adapted to: receive output voltage signal from output terminal and winding voltage signals from secondary windings; based on the output voltage signal and winding voltage signals, generate PWM signals, the number of PWM signals is the same as the number of primary side circuits, and the PWM signals are staggered in phase; and transmit PWM signals to control terminals of power switches.

Abstract: The present invention relates to an isolated switched-mode power supply (SMPS) and an SMPS system. The isolated SMPS includes N (?2) primary side circuits, N secondary side circuits, an isolated control module and N transformers. Each primary side circuit includes a power switch, and each secondary side circuit includes a synchronous rectifier. The isolated control module includes a primary side control module, an optocoupler and a secondary side control module, and is adapted to generate, based on output voltage signal and winding voltage signals from secondary windings, N PWM signals staggered in phase from one another and transmit them to control terminals of power switches, enabling staggered control of N power switches. This multi-phase control provided by the isolated control module in the isolated SMPS allows for optimized EMI shielding performance, a balanced thermal distribution, less output ripple, smaller required output capacitance and significantly improved cost effectiveness of isolated SMPS.

Abstract: The present disclosure provides a mechanical-electrical-hydraulic composite transmission device and a control method thereof. The device includes an input shaft assembly, a power-split assembly, a hydraulic transmission assembly, an electrical variable transmission assembly, a mechanical transmission assembly, a power-convergence assembly, and an output shaft. Three types of transmission modes including single transmission modes, power-split composite transmission modes, and power-convergence composite transmission modes are implemented by controlling engagement and disengagement of clutches and a brake. The present disclosure has the following beneficial effects: Free switching between various transmission modes is realized, the requirements of engineering machinery for a transmission device with multiple modes in different working conditions are satisfied, the engine power utilization is improved, and the fuel economy is increased.

Abstract: The present invention relates to transmucosal delivery systems, methods and kits that include agents to penetrate the mucus, stratified squamous epithelial layer, and basement membrane, to deliver a vasodilatory agent and active agent to the lamina propria and smooth muscle. The formulation of the present invention further includes having a mucolytic agent for thinning or decreasing viscosity of mucus; a solvent; a proteolytic agent that cleaves or fragments long chain proteins to create cellular spacing of the stratified squamous epithelial layer and/or basement membrane, a vasodilatory agent; and at least one active ingredient. The formulation allows for penetration of the active ingredient at the mucosal surface to the smooth muscle. The active ingredient, once at the smooth muscle, is delivered locally to the tissue or systemically to the blood stream.

Abstract: An antibiotic pharmaceutical composition for intradermal or subcutaneous administration is provided, which includes an antibiotic and hyaluronidase (HAase). In the antibiotic pharmaceutical composition, a content of the antibiotic is 10 mg/mL-5 g/Ml, and a content of the HAase is 45 units/ml-4500000 units/ml. A kit is provided, which includes the pharmaceutical composition. A method for preparing the kit, and use of the pharmaceutical composition are further provided.

Abstract: An isolated power converter and a control circuit thereof are disclosed. The control circuit includes a secondary side controller which receives a first sample signal characterizing an output voltage of the isolated power converter and generates a first control signal. A primary side control module receives a second sample signal characterizing primary side current and generates a second control signal which controls state of a primary side power transistor, providing PSR. A secondary side follow-up control module receives the first control signal and generates a third control signal which controls states of primary side power transistor, thus providing SSR. A control switching module receives a third sample signal characterizing output voltage and causes switching from PSR to SSR when the third sample signal satisfies a predefined condition. During startup of isolated power converter, PSR is provided first, and switching is then caused to SSR when the predefined condition is satisfied.

Abstract: A control circuit, a control chip and a power supply device are disclosed by the present invention. The control circuits are used for control of a constant-voltage closed-loop which causes a voltage of a voltage feedback signal obtained from an output voltage to approach a voltage of a reference voltage signal obtained from a base voltage and thereby achieves a constant-voltage output. In addition, when a sampled current obtained from an output current is higher than a predetermined current, or when output power is higher than a predetermined power, the control circuit increases the voltage feedback signal or decreases the reference voltage signal, causing the constant-voltage closed loop to decrease the output voltage and the output current and thereby achieving a limited output current and limited output power.

Abstract: The present invention relates to trans-epithelial membrane delivery systems, methods and kits that include an agent to penetrate the basement membrane, a membrane of the skin and mucosa previously known to be difficult to penetrate. In particular, the formulation includes a basement membrane disruptor that reversibly denatures or cleaves molecules of the basement membrane of the epithelial membrane. The formulation of the present invention further includes having at least one penetration agent, at least one vaso-modulator, and at least one active ingredient. In an embodiment, the penetration agent includes a solvent, a lipophilic agent, a hydrophilic agent, wherein the basement membrane disruptor, the vaso-modulator, and the active ingredient pass through the outer layers of the epithelial membrane. The basement membrane disruptor allows the vaso-modulator and the active ingredient pass through the basement membrane to smooth muscle.

Abstract: A control circuit, system and method for switched-mode power supply are disclosed, the control circuit is for driving a first switch to convert an input voltage into an output voltage. The control circuit includes an on-time control unit, which receives a first signal characterizing switching frequency of first switch and a second signal characterizing current flowing through first switch and responsively generates a signal indicative of a turn-off instant for first switch. When a peak value of the current flowing through the first switch drops below a predefined value, the on-time control unit determines the turn-off instant for the first switch based on the first signal so that the switching frequency of the first switch is maintained at a target frequency. This design can effectively avoid the generation of audible noise, stabilize the output voltage against load changes while maintaining desirable efficiency, and ensure operational safety of the switched-mode power supply.

Abstract: A control device and method for a flyback converter, a flyback converter and a power supply system are disclosed. The device is configured to apply a tuning voltage or current to a connection node of a secondary winding and a synchronous rectifier within a predetermined period of time after the synchronous rectifier is turned off and before a power transistor switch is turned on. It is also configured to, after the tuning voltage or current is applied, transmit a request signal requesting the power transistor switch to be turned on to a primary controller. The primary controller then turns on the power transistor switch based on the received request signal.

Abstract: A hydro-mechanical series and parallel transmission device and a control method thereof are provided. The device includes an input shaft assembly, a hydraulic transmission assembly, a planetary gear transmission assembly, an intermediate gear transmission assembly, and an output shaft assembly. Switching among a hydraulic transmission mode, a mechanical transmission mode, and a hydro-mechanical composite transmission mode is implemented through combination and engagement/disengagement of clutches and brakes. The hydro-mechanical series transmission is used to expand the speed regulation range of the hydraulic transmission and is combined with the hydraulic transmission to meet the requirements on precision and the speed regulation range. The requirements of low-power and high-power operations are met through combination of the hydro-mechanical series and parallel transmissions. Multiple transmission modes are formed to adapt to the working conditions of startup, operation, and transfer.

Abstract: Disclosed are an electrical impedance monitoring device, system and method for locomotion behaviors of C. elegans. A microfluidic channel layer and a gas channel layer form a double-layer structure by bonding, and the double-layer structure is tightly fixed to a circuit board with nylon screws. An electrode array configured as a concentric circle structure is arranged on the circuit board and used for realizing EIT monitoring of C. elegans. The microfluidic channel layer comprises a culture and monitoring chamber and a C. elegans transition channel and used for long-term culture and cyclic monitoring of C. elegans. The gas channel layer comprises a gas inlet and a gas channel and used for applying a gas pressure to squeeze an upper wall of the microfluidic channel layer to form a membrane valve to close the microfluidic channel layer.

Abstract: Disclosed are an electrical impedance monitoring device, system and method for locomotion behaviors of C. elegans. A microfluidic channel layer and a gas channel layer form a double-layer structure by bonding, and the double-layer structure is tightly fixed to a circuit board with nylon screws. An electrode array configured as a concentric circle structure is arranged on the circuit board and used for realizing EIT monitoring of C. elegans. The microfluidic channel layer comprises a culture and monitoring chamber and a C. elegans transition channel and used for long-term culture and cyclic monitoring of C. elegans. The gas channel layer comprises a gas inlet and a gas channel and used for applying a gas pressure to squeeze an upper wall of the microfluidic channel layer to form a membrane valve to close the microfluidic channel layer.

Abstract: A hybrid transmission device with a mechanical continuously variable transmission and a control method thereof are provided. The device includes an input shaft assembly, a front planetary gear transmission assembly, a rear planetary gear transmission assembly, an output shaft, and a mechanical continuously variable transmission. Single transmission modes and hybrid transmission modes are implemented through combination and engagement/disengagement of brakes and clutches. The device and the method realize free switching among various transmission modes and integrates the single transmission modes and the hybrid transmission modes, thereby increasing the degree of freedom in adjustment and expanding the speed regulation range. Input and output shafts of a front cup wheel and ring disc transmission mechanism and a rear cup wheel and ring disc transmission mechanism are coaxial, so that the structure is compact and intermediate rollers can stably and reliably transmit large torque.