Abstract: A method for simulating and predicting deep reservoir structural fractures in consideration of thickness change is disclosed. The method firstly calculates a structural fracture apparent density by using a stress-based reservoir structural fracture prediction formula group, secondly obtains structural fracture linear density based on simulation experiment, thickness unit division and reservoir structural fracture prediction optimization formula, finally carries out a reliability judgment based on the structural fracture linear density, the apparent density and the measured inspection values by using parameter inspection and error analysis. The above method can effectively reduce the difficulty and cost of energy development.