Patents by Inventor Zhengjian Zhang

Zhengjian Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tissue-specific Wnt signal enhancing molecules and uses thereof
    Patent number: 11958891
    Abstract: The present disclosure provides tissue-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in targeted tissues.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: April 16, 2024
    Assignee: Surrozen Operating, Inc.
    Inventors: Zhengjian Zhang, Jennifer Jean Brady, Aaron Ken Sato, Wen-Chen Yeh, Yang Li, Teppei Yamaguchi
  • LIVER-SPECIFIC WNT SIGNAL ENHANCING MOLECULES AND USES THEREOF
    Publication number: 20230374090
    Abstract: The present disclosure provides liver-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in liver tissues and treat liver diseases and disorders.
    Type: Application
    Filed: May 2, 2023
    Publication date: November 23, 2023
    Applicant: Surrozen Operating, Inc.
    Inventors: Yang LI, Zhengjian ZHANG, Randall J. BREZSKI, Leonard PRESTA, Thomas LOPEZ, Hui CHEN, Helene BARIBAULT, Wen-Chen YEH, Shengjiang TU
  • TISSUE-SPECIFIC WNT SIGNAL ENHANCING MOLECULES AND USES
    Publication number: 20210380678
    Abstract: The present disclosure provides tissue-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in liver tissues.
    Type: Application
    Filed: July 9, 2019
    Publication date: December 9, 2021
    Inventors: Zhengjian ZHANG, Yang LI, Wen-Chen YEH, Tom Zhiye YUAN, Helene BARIBAULT, Kuo-Pao LAI
  • TISSUE-SPECIFIC WNT SIGNAL ENHANCING MOLECULES AND USES THEREOF
    Publication number: 20200048324
    Abstract: The present disclosure provides tissue-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in targeted tissues.
    Type: Application
    Filed: January 26, 2018
    Publication date: February 13, 2020
    Inventors: Zhengjian ZHANG, Jennifer Jean BRADY, Aaron Ken SATO, Wen-Chen YEH, Yang LI, Teppei YAMAGUCHI
  • Azetidine-substituted fluorescent compounds
    Patent number: 10495632
    Abstract: The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: December 3, 2019
    Assignee: HOWARD HUGHES MEDICAL INSTITUTE
    Inventors: Luke D. Lavis, Jonathan B. Grimm, Jiji Chen, Timothee Lionnet, Zhengjian Zhang, Andrey Revyakin, Joel Slaughter
  • AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS
    Publication number: 20190107534
    Abstract: The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 11, 2019
    Inventors: Luke D. LAVIS, Jonathan B. GRIMM, Jiji CHEN, Timothee LIONNET, Zhengjian ZHANG, Andrey REVYAKIN, Joel SLAUGHTER
  • Azetidine-substituted fluorescent compounds
    Patent number: 10161932
    Abstract: The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: December 25, 2018
    Assignee: HOWARD HUGHES MEDICAL INSTITUTE
    Inventors: Luke D. Lavis, Jonathan B. Grimm, Jiji Chen, Timothee Lionnet, Zhengjian Zhang, Andrey Revyakin, Joel Slaughter
  • AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS
    Publication number: 20180284105
    Abstract: The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
    Type: Application
    Filed: June 5, 2018
    Publication date: October 4, 2018
    Inventors: Luke D. LAVIS, Jonathan B. GRIMM, Jiji CHEN, Timothee LIONNET, Zhengjian ZHANG, Andrey REVYAKIN, Joel SLAUGHTER
  • Azetidine-substituted fluorescent compounds
    Patent number: 10018624
    Abstract: The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: July 10, 2018
    Assignee: HOWARD HUGHES MEDICAL INSTITUTE
    Inventors: Luke D. Lavis, Jonathan B. Grimm, Jiji Chen, Timothee Lionnet, Zhengjian Zhang, Andrey Revyakin, Joel Slaughter
  • AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS
    Publication number: 20180172677
    Abstract: The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
    Type: Application
    Filed: February 15, 2018
    Publication date: June 21, 2018
    Inventors: Luke D. LAVIS, Jonathan B. GRIMM, Jiji CHEN, Timothee LIONNET, Zhengjian ZHANG, Andrey REVYAKIN, Joel SLAUGHTER
  • Azetidine-substituted fluorescent compounds
    Patent number: 9933417
    Abstract: The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: April 3, 2018
    Assignee: HOWARD HUGHES MEDICAL INSTITUTE
    Inventors: Luke D. Lavis, Jonathan B. Grimm, Jiji Chen, Timothee Lionnet, Zhengjian Zhang, Andrey Revyakin, Joel Slaughter
  • Surface Passivation Methods for Single Molecule Imaging of Biochemical Reactions
    Publication number: 20120231447
    Abstract: The present disclosure provides methods for treating a surface for single-molecule imaging.
    Type: Application
    Filed: February 15, 2012
    Publication date: September 13, 2012
    Applicant: HOWARD HUGHES MEDICAL INSTITUTE
    Inventors: Zhengjian Zhang, Andrey Revyakin, Steve Chu, Robert Tijan